Studies on regulation of energy metabolism via central nervous system in neonatal chicks

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 16380191
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied animal science
• Research Institution: KYUSHU UNIVERSITY
• Principal Investigator: FURUSE Mitsuhiro KYUSHU UNIVERSITY, Faculty of Agriculture, Professor, 大学院・農学研究院, 教授 (30209176)
• Co-Investigator(Kenkyū-buntansha): TACHIBANA Tetsuya KYUSHU UNIVERSITY, Faculty of Agriculture, Research Associate, 大学院・農学研究院, 助手 (80346832)
• Project Period (FY): 2004 – 2005
• Keywords: thyrotropin-releasing hormone / thyroxine / triiodothyronine / rectal temperature / heat production / chick / brain / corticotropin-releasing factor

Research Abstract

To understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamus-pituitary-thyroid axis, was investigated. Intracerebroventricular (i.c.v.) injection of TRH increased body temperature, but did not change plasma triiodothyronine (T_3) and thyroxine (T_4) concentrations. Intraperitoneal (i.p.) injection of T_3 and T_4 did not influence body temperature. Thereafter, the relationships between TRH and the hypothalamus-pituitary-adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T_3 and T_4 concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus-pituitary-adrenal axis rather than the hypothalamus-pituitary-thyroid axis. Heat production during embryonic stages were influenced by genetic selection. On the other hand, nutrients influencing chick behaviors were found out. Carnosine inhibited food intake and iduced hyperactiveity. The constituents of carnosine, β-alanine (β-Ala) and L-histidine (His), also inhibited food intake, whereas β-Ala plus His induced hypoactivity manifested as sleep-like behavior. Central creatine, phosphatidylserine, L-serine and (-)-epigallocatechin gallate reduced the stress responses in chicks.

Research Products

• [Journal Article] Dietary β-alanine enhances brain, but not muscle, carnosine and anserine concentrations in broilers (2006)
  • Author(s): Tomonaga, S. et al.
  • Journal Title: Animal Science Journal 77(1) Pages: 79-86
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvement of CRF on the anorexic effect of GLP-1 in layer chicks (2006)
  • Author(s): Tachibana, T. et al.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 143(1) Pages: 112-117
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain (2006)
  • Author(s): Adachi, N. et al.
  • Journal Title: European Journal of Pharmacology 531(1-3) Pages: 171-175
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Heat production and lipid metabolism in broiler and layer chickens during embryonic development (2006)
  • Author(s): Sato, M. et al.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 143(3) Pages: 382-388
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Intracerebroventricular injection of L-serine analogs and derivatives induces sedative and hypnotic effects under an acute stressful condition in neonatal chicks (2006)
  • Author(s): Asechi, M. et al.
  • Journal Title: Behavioural Brain Research, (in Press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dietary β-alanine enhances brain, but not muscle, carnosine and anserine concentrations in broilers. (2006)
  • Author(s): Tomonaga, S., Kaneko, K., Kaji, Y., Kido, Y., Denbow, D.M., Furuse, M.
  • Journal Title: Animal Science Journal 77(1) Pages: 79-86
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of CRF on the anorexic effect of GLP-1 in layer chicks. (2006)
  • Author(s): Tachibana, T., Sato, M., Oikawa, D., Furuse, M.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 143(1) Pages: 112-117
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain. (2006)
  • Author(s): Adachi, N., Tomonaga, S., Tachibana, T., Denbow, D.M., Furuse, M.
  • Journal Title: European Journal of Pharmacology 531(1-3) Pages: 171-175
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heat production and lipid metabolism in broiler and layer chickens during embryonic development. (2006)
  • Author(s): Sato, M., Tachibana, T., Furuse, M.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 143(3) Pages: 382-388
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intracerebroventricular injection of L-serine analogs and derivatives induces sedative and hypnotic effects under an acute stressful condition in neonatal chicks. (2006)
  • Author(s): Asechi, M., Tomonaga, S., Tachibana, T., Han, L., Hayamizu, K., Denbow, D.M., Furuse, M.
  • Journal Title: Behavioural Brain Research (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks (2005)
  • Author(s): Saito, E.-S.et al.
  • Journal Title: Regulatory Peptides 125(1-3) Pages: 201-208
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Distributions of proglucagon mRNA and GLP-1in the brain of chicks (2005)
  • Author(s): Tachibana, T. et al.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 140(2) Pages: 203-207
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Brain creatine functions to attenuate acute stress responses through gabanergic system in chicks (2005)
  • Author(s): Koga, Y. et al.
  • Journal Title: Neuroscience 132(1) Pages: 65-71
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulation of body temperature by thyrotropin releaing hormone in neonatal chicks (2005)
  • Author(s): Takahashi, H. et al.
  • Journal Title: Developmental Brain Research 157(1) Pages: 58-64
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Central administration of phosphatidylserine attenuates isolation stress induced behavior in chicks (2005)
  • Author(s): Koutoku, T. et al.
  • Journal Title: Neurochemistry Internatioal 47(3) Pages: 183-189
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks (2005)
  • Author(s): Tachibana, T. et al.
  • Journal Title: Brain Research 1050(1-2) Pages: 94-100
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oral administration of β-alanine carnosine concentratios in the muscles and brains of chickens (2005)
  • Author(s): Tomonaga, S. et al.
  • Journal Title: Animal Science Journal 76(3) Pages: 249-254
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] ICV CRF and isolation differentially enhance plasma corticosterone concentrations in layer-and meat-type neonatal chicks (2005)
  • Author(s): Saito, S. et al.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 141(3) Pages: 305-309
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] ICV melatonin reduces acute stress responses in neonatal chicks (2005)
  • Author(s): Saito, S. et al.
  • Journal Title: Behavioural Brain Research 165(2) Pages: 197-203
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Comparison of mammalian prolactin-releasing peptide and Carassius RFamide for feeding behavior and prolactin secretion in chicks (2005)
  • Author(s): Tachibana, T. et al.
  • Journal Title: General and Comparative Endocrinology 144(3) Pages: 264-269
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nitric oxide involves in carnosine induced hyperactivity in chicks (2005)
  • Author(s): Tomonaga, S. et al.
  • Journal Title: European Journal of Pharmacology 524(1-3) Pages: 84-88
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. (2005)
  • Author(s): Saito, E.-S., Kaiya, H., Tachibana, T., Tomonaga, S., Denbow, D.M., Kangawa, K., Furuse, M.
  • Journal Title: Regulatory Peptides 125(1-3) Pages: 201-208
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distributions of proglucagon mRNA and GLP-1 in the brain of chicks. (2005)
  • Author(s): Tachibana, T., Hiramatsu, K., Furuse, M., Hasegawa, S., Yoshizawa, F., Sugahara, K.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 140(2) Pages: 203-207
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Brain creatine functions to attenuate acute stress responses through gabanergic system in chicks. (2005)
  • Author(s): Koga, Y., Takahashi, H., Oikawa, D., Tachibana, T., Denbow, D.M., Furuse, M.
  • Journal Title: Neuroscience 132(1) Pages: 65-71
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of body temperature by thyrotropin releaing hormone in neonatal chicks. (2005)
  • Author(s): Takahashi, H., Iigo, M., Ando, K., Tachibana, T., Denbow, D.M., Furuse, M.
  • Journal Title: Developmental Brain Research 157(1) Pages: 58-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Central administration of phosphatidylserine attenuates isolation stress induced behavior in chicks. (2005)
  • Author(s): Koutoku, T., Takahashi, H., Tomonaga, S., Oikawa, D., Saito, S., Tachibana, T., Han, L., Hayamizu, K., Denbow, D.M., Furuse, M.
  • Journal Title: Neurochemistry International 47(3) Pages: 183-189
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks. (2005)
  • Author(s): Tachibana, T., Sato, M., Takahashi, H., Ukena, K., Tsutsui, K., Furuse, M.
  • Journal Title: Brain Research 1050(1-2) Pages: 94-100
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oral administration of β-alanine modifies carnosine concentratios in the muscles and brains of chickens. (2005)
  • Author(s): Tomonaga, S., Kaji, Y., Tachibana, T., Denbow, D.M., Furuse, M.
  • Journal Title: Animal Science Journal 76(3) Pages: 249-254
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ICV CRF and isolation differentially enhance plasma corticosterone concentrations in layer- and meat-type neonatal chicks. (2005)
  • Author(s): Saito, S., Tachibana, T., Choi, Y.-H., Denbow, D.M., Furuse, M.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 141(3) Pages: 305-309
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ICV melatonin reduces acute stress responses in neonatal chicks. (2005)
  • Author(s): Saito, S., Tachibana, T., Choi, Y.-H., Denbow, D.M., Furuse, M.
  • Journal Title: Behavioural Brain Research 165(2) Pages: 197-203
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of mammalian prolactin-releasing peptide and Carassius RFamide for feeding behavior and prolactin secretion in chicks. (2005)
  • Author(s): Tachibana, T., Tsukada, A., Fujimoto, M., Takahashi, H., Ohkubo, T., Boswell, T., Furuse, M.
  • Journal Title: General and Comparative Endocrinology 144(3) Pages: 264-269
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nitric oxide involves in carnosine induced hyperactivity in chicks. (2005)
  • Author(s): Tomonaga, S., Tachibana, T., Takahashi, H., Sato, M., Denbow, D.M., Furuse, M.
  • Journal Title: European Journal of Pharmacology 524(1-3) Pages: 84-88
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The hypothalamus is involved in the anorexic effect of glucagon-like poptide-1 in chicks (2004)
  • Author(s): Tachibana, T. et al.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 137(1) Pages: 183-188
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of central administration of prolactin-releasing peptide on feeding in chicks (2004)
  • Author(s): Tachibana, T. et al.
  • Journal Title: Physiology & Buhavior 80(5) Pages: 713-719
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of central administration of canosine and its constituents on behavior in chicks (2004)
  • Author(s): Tomonaga, S. et al.
  • Journal Title: Brain Research Bulletin 63(1) Pages: 75-82
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks (2004)
  • Author(s): Zhang, R. et al.
  • Journal Title: Behavioral Brain Research 151(1-2) Pages: 47-52
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Comparison of brain arginie-vasotocin and corticotrophin-releasing factor for physiological responses in chicks (2004)
  • Author(s): Tachibana, T. et al.
  • Journal Title: Neuroscience Letters 360(3) Pages: 165-169
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Anorexigenic effects of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide in the chick brain are mediated by corticotrophin-releasing factor (2004)
  • Author(s): Tachibana, T. et al.
  • Journal Title: Regulatory Peptides 120(1-3) Pages: 99-105
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differences in catecholamine metabolism and behavior in neonatal broiler and layer chicks (2004)
  • Author(s): Saito, S. et al.
  • Journal Title: British Poultry Science 45(2) Pages: 158-162
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Intracerbroventricular administration of chicken motilin does not induce hyperphagia in meat-type chicks (2004)
  • Author(s): Bungo, T. et al.
  • Journal Title: Physiology & Behavior 82(2-3) Pages: 199-203
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks. (2004)
  • Author(s): Tachibana, T., Hirofuji, K., Matsumoto, M., Furuse, M., Hasegawa, S., Yoshizawa, F., Sugahara, K.
  • Journal Title: Comparative Biochemistry and Physiology A, Molecular and Integrative Physiology 137(1) Pages: 183-188
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of central administration of prolactin-releasing peptide on feeding in chicks. (2004)
  • Author(s): Tachibana, T., Saito, S., Tomonaga, S., Takagi, T., Saito, E.-S., Nakanishi, T., Koutoku, T., Tsukada, A., Ohkubo, T., Boswell, T., Furuse, M.
  • Journal Title: Physiology & Behavior 80(5) Pages: 713-719
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of central administration of carnosine and its constituents on behaviors in chicks. (2004)
  • Author(s): Tomonaga, S., Tachibana, T., Takagi, T., Saito, E.-S., Zhang, R., Denbow, D.M., Furuse, M.
  • Journal Title: Brain Research Bulletin 63(1) Pages: 75-82
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks. (2004)
  • Author(s): Zhang, R., Tachibana, T., Takagi, T., Koutoku, T., Denbow, D.M., Furuse, M.
  • Journal Title: Behavioural Brain Research 151(1-2) Pages: 47-52
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of brain arginine-vasotocin and corticotrophin-releasing factor for physiological responses in chicks. (2004)
  • Author(s): Tachibana, T., Saito, E.-S., Saito, S., Tomonaga, S., Denbow, D.M., Furuse, M.
  • Journal Title: Neuroscience Letters 360(3) Pages: 165-169
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anorexigenic effects of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide in the chick brain are mediated by corticotrophin-releasing factor. (2004)
  • Author(s): Tachibana, T., Saito, E.-S., Takahashi, H., Saito, S., Takagi, T., Boswell, T., Furuse, M.
  • Journal Title: Regulatory Peptides 120(1-3) Pages: 99-105
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differences in catecholamine metabolism and behavior in neonatal broiler and layer chicks. (2004)
  • Author(s): Saito, S., Takagi, T., Koutoku, T., Saito, E.-S., Hirakawa, H., Tomonaga, S., Tachibana, T., Denbow, D.M., Furuse, M.
  • Journal Title: British Poultry Science 45(2) Pages: 158-162
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intracerebroventricular administration of chicken motilin does not induce hyperphagia in meat-type chicks. (2004)
  • Author(s): Bungo, T., Ueda, H., Kitazawa, T., Taneike, T., Furuse, M.
  • Journal Title: Physiology & Behavior 82(2-3) Pages: 199-203
  • Description: 「研究成果報告書概要(欧文)」より