2007 Fiscal Year Final Research Report Summary
Analysis of the stress resistance functions of Prolyl Isomerase Pin1
| Project/Area Number |
16380225
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tohoku University |
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Principal Investigator |
UCHIDA Takafumi Tohoku University, Tohoku University, Graduate School of Agricultural Scinece, Professor (80312239)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Chiyoko Ibaraki University, Health Center, Associate Professor (80312776)
RYONG-WOON Shin Tohoku University, Graduate School of Medicine, Associate Professor (40271910)
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| Project Period (FY) |
2004 – 2007
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| Keywords | peptidyl prolyl cis / trans isomerase / Pin1 / Myc / p53 / Amyloid / Notch1 / thymus / Alzheimer''s disease |
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| Research Abstract |
We found that. Pin1 is a stress resistance protein that is related to cancer and Alzheimer's disease. Pin1 regulates the stability of an oncogene, c-myc. C-myc is degraded by ubiquitination. If myc is not degraded and remains in the cell, the cell becomes immortalized and develops to cancer cell. Therefore Pin1 functions to resist to the stress of tumor development. The mice without Pin1 and p53 developed thymoma, which is caused by over production of NIC, activated Notch1. Pin1 also suppresses the tumor signal of Notch1. In brains, Pin1 regulate the production of Amyloid beta from amyloid precursor protein. Pin1 binds to the phosphoThr668 and changes the conformation of the site cut by g-secretase. Production of amyloid beta is considered one of the most important events in the development of Alzheimer's disease. Our finding will be useful to diagnose and produce a drug for Alzheimer's disease. We also discovered that Pin1 activates Stat3 signal, which is related to inflammation and immunity. This is the other example showing that. Pint is a responder to the stress to the cell or body. We also found that. Pin1 suppresses the apoptosis caused by spinal cord injury. We guessed there are molecules that function like Pin1 in the body to suppress. The stress, and found Gas7 that has similar amino acid sequence to Pin T. The level of Gas7 is very low in the brains of the patients with Alzheimer's disease. We think Gas7 may be another stress responsive protein like Pin1.
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[Journal Article] Topology of AspT, the aspartate: alanine antiporter of Tetragenococcus halophilus, determined by site-directed fluorescence labeling2007
Author(s)
Nanatani K, Fujiki T, Kanou K, Takeda-Shitaka M, Umeyama H, Ye L, Wang X, Nakajima T, Uchida T, maloney PC, Abe K.
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Journal Title
J Bacteriol 189
Pages: 7089-7097
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Comparative analysis of ATP-binding cassette (ABC) transporter gene expression levels in peripheral blood leukocytes and in liver with hepatocellular carinoma2004
Author(s)
Moustafa, MA., Ogino, D., Nishimura, M., ueda, N., Naito, S., Furukawa, M. Uchida, T., Ikai, I.., Sawada, H., Fukumoto, M.
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Journal Title
Cancer Sci. 95(6)
Pages: 530-536
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cytochrome P450 Gene expression levels in peripheral blood mononuclear cells in comparison with the liver2004
Author(s)
Furukawa, M., Nishimura, M., Ogino, D., Chiba, R., Ikai, I., Ueda, N., Naito, Kuribayashi, S., Moustafa, MA. Uchida, T., Sawada, H., Kamataki, T., Funae, Y., Fukumoto, M.
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Journal Title
S, Cancer Sci. 95(6)
Pages: 520-529
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A signaling pathway controlling myc degradation that impacts oncogenic transformation of human cells2004
Author(s)
Yeh, E, Cunnigham, M. Arnold, H. Chasse, D., Moteith, T., Ivaldi, G., Hahn, WC., Stukengerg, T., Shenolikar, S., Uchida, T., Counter, CM.,Nevins, JR., Means, AR. And Sears R.
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Journal Title
Nature Cell Biol. 6(4)
Pages: 308-318
Description
「研究成果報告書概要(欧文)」より
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