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2006 Fiscal Year Final Research Report Summary

Analysis of Brain Function and Prevention of Brain Diseases focused on the Action of Trace Metals

Research Project

Project/Area Number 16390035
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

TAKEDA Atsushi  University of Shizuoka, Department of Medical Biochemistry, Associate Professor, 薬学部, 助教授 (90145714)

Project Period (FY) 2004 – 2006
Keywordszinc / hippocampus / glutamate / zinc-deficient diet / synaptic neurotransmission / glutamate excitotoxicity / calcium / essential trace metal
Research Abstract

1. Enhanced glutamate exicitotoxicity in the hippocampus in zinc deficiency
Glutamate exitotoxicity is a final common pathway for numerous pathological processes such as Alzheimer's disease and amyotrophic lateral sclerosis, in addition to stroke/ischemia and temporal lobe epilepsy. Susceptibility to kainate-induced seizures was enhanced in zinc-deficient mice and rats. Glutamate exicitotoxicity is enhanced in the hippocampus in zinc deficiency
2. Role of zinc in synaptic neurotransmission in the hippcampus
Zinc exists in high densities in the giant boutons of hippocampal mossy fibers. On the basis of the evidence that zinc decreases extracellular glutamate concentration in the hippocampus, the presynaptic action of zinc released from mossy fibers during tetanic stimulation was examined using hippocampal slices. Zinc released from mossy fibers is a negative-feedback factor against presynaptic activity during tetanic stimulation.
3. Unique response of hippocampal zinc to Novelty Stress
To analyze the response of extracellular zinc in the hippocampus against novelty stress, rats were placed for 50 min in a novel environment once a day for 8 days. Extracellular glutamate in the hippocampus was increased during exploratory behavior on day 1, whereas extracellular zinc was decreased. Extracellular zinc returned to the basal level during exploratory behavior on day 8. The decrease in extracellular zinc and the increase in extracellular glutamate in exploratory period were abolished by perfusion with CaEDTA, a membrane-impermeable zinc chelator.. These results suggest that zinc uptake by hippocampal cells is linked to exploratory activity and is required for the activation of glutamatergic neurotransmitter system.

  • Research Products

    (50 results)

All 2007 2006 2005 2004

All Journal Article (48 results) Book (2 results)

  • [Journal Article] Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release2007

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      J. Neurosci. Res. 85

      Pages: 1310-1317

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Anxiety-like behavior of young rats after 2-week zinc deprivation2007

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Behav. Brain Res. 177

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Response of hippocampal mossy fiber zinc to excessive glutamate release2007

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Neurochem. Int. 50

      Pages: 322-327

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release.2007

    • Author(s)
      Atsushi Takeda, Sayuri Fuke, Akira Minami, Naoto Oku
    • Journal Title

      J.Neurosci.Res. 85

      Pages: 1310-1317

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Anxiety-like behavior of young rats after 2-week zinc deprivation.2007

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Fumika Kan, Hiromasa Itoh, Naoto Oku
    • Journal Title

      Behav.Brain Res. 177

      Pages: 1-6

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Response of hippocampal mossy fiber zinc to excessive glutamate release.2007

    • Author(s)
      Atsushi Takeda, Akira Minami, Naomi Sakurada, Satoko Nakajima, Naoto Oku
    • Journal Title

      Neurochem.Int. 50

      Pages: 322-327

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortex2006

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Brain Res. 1118

      Pages: 52-57

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Response of extracelluar zinc in the ventral hippocampus against novelty stress2006

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      J. Neurochem. 99

      Pages: 670-676

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation2006

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Neurochem. Int. 49

      Pages: 746-750

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency2006

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Epilepsy Res. 70

      Pages: 41-48

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Responsiveness to kainate in young rats after 2-week zinc deprivation2006

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      BioMetals 19

      Pages: 565-572

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation2006

    • Author(s)
      Akira Minami et al.
    • Journal Title

      J. Neurosci. Res. 83

      Pages: 167-176

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Zinc release from Schaffer collaterals and its significance2006

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Brain Res.Bull. 68

      Pages: 442-447

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Inhibitory modulatuon of glutamatergic neuron activity by zinc in the hippocampus2006

    • Author(s)
      Atsushi Takeda
    • Journal Title

      Biomed. Res. Trace Elements 17

      Pages: 399-405

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 生体での亜鉛の多彩な働き : 遺伝子発現から学習・記憶に至るまで2006

    • Author(s)
      武田 厚司
    • Journal Title

      化学と教育 54

      Pages: 478-481

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency.2006

    • Author(s)
      Atsushi Takeda, Hiromasa Itoh, Maki Hirate, Naoto Oku
    • Journal Title

      Epilepsy Res. 70

      Pages: 41-48

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Responsiveness to kainate in young rats after 2-week zinc deprivation.2006

    • Author(s)
      Atsushi Takeda, Hiromasa Itoh, Haruna Tamano, Naoto Oku
    • Journal Title

      BioMetals 19

      Pages: 565-572

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation.2006

    • Author(s)
      Akira Minami, Naomi Sakurada, Sayuri Fuke, Kazuya Kikuchi, Tetsuo Nagano, Naoto Oku, Atsushi Takeda
    • Journal Title

      J.Neurosci.Res. 83

      Pages: 167-176

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Zinc release from Schaffer collaterals and its significance.2006

    • Author(s)
      Atsushi Takeda, Satoko Nakajima, Sayuri Fuke, Naomi Sakurada, Akira Minami, Naoto Oku
    • Journal Title

      Brain Res.Bull. 68

      Pages: 442-447

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortex.2006

    • Author(s)
      Atsushi Takeda, Sachie Imano, Hiromasa Itoh, Naoto Oku
    • Journal Title

      Brain Res. 1118

      Pages: 52-57

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Response of extracelluar zinc in the ventral hippocampus against novelty stress.2006

    • Author(s)
      Atsushi Takeda, Naomi Sakurada, Shingo Kanno, Akira Minami, Naoto Oku
    • Journal Title

      J.Neurochem. 99

      Pages: 670-676

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation.2006

    • Author(s)
      Atsushi Takeda, Hiromasa Itoh, Sachie Imano, Naoto Oku
    • Journal Title

      Neurochem.Int. 49

      Pages: 746-750

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Inhibitory modulatuon of glutamatergic neuron activity by zinc in the hippocampus.2006

    • Author(s)
      Atsushi Takeda
    • Journal Title

      Biomed.Res.Trace Elements 17

      Pages: 399-405

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Involvement of Unusual Glutamate Release in kainate-induced seizures in zinc-deficient adult rats2005

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Epilepsy Res. 66

      Pages: 137-143

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Increase in hippocampal cell death after treatment with kainate in zinc deficiency2005

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Neurochem. Int. 47

      Pages: 539-544

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency2005

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Epilepsy Res. 63

      Pages: 77-84

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Zinc homeostasis in the hippocampus of zinc-deficient young adult rats2005

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Neurochem. Int. 46

      Pages: 221-225

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Involvement of Unusual Glutamate Release in kainate-induced seizures in zinc-deficient adult rats.2005

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Naoto Oku
    • Journal Title

      Epilepsy Res. 66

      Pages: 137-143

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Increase in hippocampal cell death after treatment with kainate in zinc deficiency.2005

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Akito Nagayoshi, Kohei Yamada, Naoto Oku
    • Journal Title

      Neurochem.Int. 47

      Pages: 539-544

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency.2005

    • Author(s)
      Atsushi Takeda, Kohei Yamada, Akira Minami, Tetsuo Nagano, Naoto Oku
    • Journal Title

      Epilepsy Res. 63

      Pages: 77-84

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Zinc homeostasis in the hippocampus of zinc-deficient young adult rats.2005

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Minori Tochigi, Naoto Oku
    • Journal Title

      Neurochem.Int. 46

      Pages: 221-225

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Change of zinc uptake under growth arrest and apoptosis2004

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Anticancer Res. 24

      Pages: 869-3874

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Suppressive effect of Saiko-ka-ryukotsu-borei-to, a herbal medicine, on excessive release of glutamate in the hippocampus2004

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Brain Res. Bull. 64

      Pages: 273-277

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Release of amino acids by zinc in the hippocampus2004

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Brain Res. Bull. 63

      Pages: 253-257

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Involvement of amygdalar extracellular zinc in rat behavior for passive avoidance2004

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      Neurosci. Lett. 358

      Pages: 119-122

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus2004

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      J. Neurosci. Res. 75

      Pages: 225-229

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Elimination of zinc-65 from the brain under kainate-induced seizures2004

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      BioMetals 17

      Pages: 141-144

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Analysis of brain function and prevention of brain diseases : the action of trace metals2004

    • Author(s)
      Atsushi Takeda et al.
    • Journal Title

      J. Health Sci. 50

      Pages: 429-442

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 生体微量金属の作用に着目した脳機能解析と脳疾患の予防2004

    • Author(s)
      武田厚司
    • Journal Title

      薬学雑誌 124

      Pages: 577-585

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 中枢神経系における微量金属の生理作用と毒性作用2004

    • Author(s)
      武田厚司
    • Journal Title

      CLINICAL CALCIUM 14

      Pages: 1223-1227

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 脳神経系における重金属の動態と作用解析2004

    • Author(s)
      武田厚司
    • Journal Title

      薬学研究の進歩20

      Pages: 55-62

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Change of zinc uptake under growth arrest and apoptosis.2004

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Yuko Ibuki
    • Journal Title

      Anticancer Res. 24

      Pages: 3869-3874

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Suppressive effect of Saiko-ka-ryukotsu-borei-to, a herbal medicine, on excessive release of glutamate in the hippocampus.2004

    • Author(s)
      Haruna Tamano, Atsushi Takeda
    • Journal Title

      Brain Res.Bull. 64

      Pages: 273-277

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Release of amino acids by zinc in the hippocampus.2004

    • Author(s)
      Atsushi Takeda, Akira Minami, Yumiko Seki, Satoko Nakajima, Naoto Oku
    • Journal Title

      Brain Res.Bull. 63

      Pages: 253-257

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Involvement of amygdalar extracellular zinc in rat behavior for passive avoidance.2004

    • Author(s)
      Atsushi Takeda, Akira Minami, Yumiko Seki, Naoto Oku
    • Journal Title

      Neurosci.Lett. 358

      Pages: 119-122

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus.2004

    • Author(s)
      Atsushi Takeda, Akira Minami, Yumiko Seki, Naoto Oku
    • Journal Title

      J.Neurosci.Res. 75

      Pages: 225-229

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Elimination of zinc-65 from the brain under kainate-induced seizures.2004

    • Author(s)
      Atsushi Takeda, Maki Hirate, Naoto Oku
    • Journal Title

      BioMetals 17

      Pages: 141-144

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Analysis of brain function and prevention of brain diseases : the action of trace metals.2004

    • Author(s)
      Atsushi Takeda
    • Journal Title

      J.Health Sci. 50

      Pages: 429-442

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 生命元素事典2006

    • Author(s)
      武田厚司他
    • Total Pages
      4
    • Publisher
      オーム社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 環境・健康科学辞典2005

    • Author(s)
      武田厚司他
    • Total Pages
      15
    • Publisher
      丸善
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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