Novel roles of neurohypophyseal hormones and biological active substances on brain function in genetic animal model

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 16390061
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: UETA Yoichi University of Occupational and Environmental Health, Japan, School of Medicine, Professor, 医学部, 教授 (10232745)
• Co-Investigator(Kenkyū-buntansha): NOMURA Masayoshi University of Occupational and Environmental Health, Japan, School of Medicine, Research Associate, 医学部, 助手 (80369066) ; FUJIHARA Hiroaki University of Occupational and Environmental Health, Japan, School of Medicine, Research Associate, 医学部, 助手 (10369051) ; KAWATA Mitsuhiro Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Professor, 医学研究科, 教授 (60112512)
• Project Period (FY): 2004 – 2006
• Keywords: transgenic rat / vasopressin / oxytocin / GFP / hypothalamus / posterior pituitary gland / peptide

Research Abstract

Neurohypophyseal hormones (vasopressin and oxytocin) are produced in the neurosecretory cells in the paraventricular and supraoptic nuclei of the hypothalamus, and they are secreted into the systemic circulation from the terminals of the posterior pituitary gland. Vasopressin is known to be anti-diuretic hormone and oxytociin s involved in the delivery and milk-ejection reflex. Recently, we succeeded to generate vasopressin-GFP transgenic rats and oxytocin-CFP transgenic rats. Under fluorescent microscopy we can observe green fluorescence in vasopressin-secreting neurons and blue fluorescence in oxytocin-secreting neurons. The obtained results are as follow. (1) The vasopressin-GFP fusion gene showed exaggerated response to salt loading without disturbance of body fluid homeostasis in the transgenic rats. (2) The GFP fluorescence was distributed in not only the hypothalamo-neurohypophyseal system but also several brain areas such as the locus coeruleus in colchicines-treated vasopressin-GFP transgenic rats. (3) The gene expression of GFP as well as vasopressin and Per1, 2 in the suprachiasmatic nucleus showed circadian rhythm. (4) It was useful to examine the effects of novel peptides on isolated vasopressin-GFP neuron, by using whole-cell patch-clamp technique. (5) The GFP fluorescence in the posterior pituitary gland was monitored by online GFP-monitoring system. Next, we make a plan to generate double transgenic (vasopressin-GFP and oxytocin-CFP) rats.

Research Products

• [Journal Article] Centrally and peripherally administered ghrelin potently inhibits water intake in rats. (2007)
  • Author(s): Hashimoto, H., Fujihara, H., Kawasaki, M., Saito, T., Shibata, M., Otsubo, H., Takei, Y., Ueta.Y.
  • Journal Title: Endocrinology 148(4) Pages: 1638-1647
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Physiological studies of stress responses in the hypothalamus of vasopressin-enhanced green fluorescent protein transgenic rat. (2007)
  • Author(s): Shibata, M., Fujjihara, H., Suzuki, H., Ozawa, H., Kawata, M., Dayanithi, G., Murphy, D., Ueta.Y.
  • Journal Title: Journal of Neuroendocrinology 19(4) Pages: 285-292
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Centrally and peripherally administered ghrelin potently inhibits water intake in rats. (2007)
  • Author(s): Hashimoto, H.Fujihara, H.Kawasaki, M.Saito, T.Shibata, M.Otsubo, H.Takei, Y., Ueta, Y.
  • Journal Title: Endocrinology 148(4) Pages: 1638-1647
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Physiological studies of stress responses in the hypothalamus of vasopressin-enhanced green fluorescent protein transgenic rat. (2007)
  • Author(s): Shibata, M.Fujjihara, H.Suzuki, H.Ozawa, H.Kawata, M.Dayanithi, G.Murphy, D., Ueta, Y.
  • Journal Title: Journal of Neuroendocrinology 19(4) Pages: 285-292
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of the short chain sugar acid 2-buten-4-olide on the hypothalamo-pituitary-adrenal axis in normal and adjuvant-induced arthritic rats. (2007)
  • Author(s): Kawasaki, M.Onaka, T.Saito, J.Hashimoto, H.Suzuki, H.Otsubo, H.Fujihara, H.Okimoto, N.Ohnishi, H.Nakamura, T., Ueta, Y.
  • Journal Title: Journal of Neuroendocrinology 19(1) Pages: 54-65
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of the short chain sugar acid 2-buten-4-olide on the hypothalamo-pituitary- adrenal axis in normal and adjuvant-induced arthritic rats. (2006)
  • Author(s): Kawasaki, M., Onaka, T., Saito, J., Hashimoto, H., Suzuki, H., Otsubo, H., Fujihara, H., Okimoto, N., Ohnishi, H., Nakamura, T., Ueta.Y.
  • Journal Title: Journal of Neuroendocrinology 19(1) Pages: 54-65
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Exaggerated response of arginine vasopressin-enhanced green fluorescent protein fusion gene to salt loading without disturbance of body fluid homeostasis in rats. (2006)
  • Author(s): Fujio, T., Fujihara, H., Shibata, M., Yamada, S., Onaka, T., Tanaka, K., Morita, H., Dayanithi, G., Kawata, M., Murphy, D., Ueta.Y.
  • Journal Title: Journal of Neuroendocrinology 18(10) Pages: 776-785
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Centrally administered neuropeptide W-30 activates magnocellular neurosecretory cells in the supraoptic and paraventricular nuclei with neurosecretion in rats (2006)
  • Author(s): Kawasaki, M., Onaka, T., Nakazato, M., Saito, J., Mera, T., Hashimoto, H., Fujihara, H., Okimoto, N., Ohnishi, H., Nakamura, T., Ueta.Y.
  • Journal Title: Journal of Endocrinology 190(2) Pages: 213-223
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus (2006)
  • Author(s): Mera T, Fujihara H, Kawasaki M, Hashimoto H, Saito T, Shibata M, Saito J, Oka T, Tsuji S, Onaka T, Ueta, Y
  • Journal Title: Neuroscience 141(2) Pages: 1069-1086
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Thehypothalamo-pituitaryaxis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase (2006)
  • Author(s): Akasaka, S., Nomura, M., Nishii, H., Fujimoto, N., Ueta.Y., Tsutsui, M., Shimokawa, H., Yanagihara, N., Matsumoto, T
  • Journal Title: Brain Research 1089(1) Pages: 1-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The short chain sugar acid, 2-buten-4-olide, activates oxytocin-secreting neurons but not arginine vasopressin-secreting neurons in the hypothalamus of rats. (2006)
  • Author(s): Kawasaki, M., Yamaga, C., Onaka, T., Saito, J., Mera, T., Hashimoto, H., Fujihara, H., Okimoto, N., Ohnishi, H., Nakamura, T., Ueta.Y.
  • Journal Title: Brain Research 1086(1) Pages: 133-141
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Exaggerated response of arginine vasopressin-enhanced green fluorescent protein fusion gene to salt loading without disturbance of body fluid homeostasis in rats. (2006)
  • Author(s): Fujio, T.Fujihara, H.Shibata, M.Yamada, S.Onaka, T.Tanaka, K.Morita, H.Dayanithi, G Kawata, M.Murphy, D., Ueta, Y.
  • Journal Title: Journal of Neuroendocrinology 18(10) Pages: 776-85
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Centrally administered neuropeptide W-30 activates magnocellular neurosecretory cells in the supraoptic and paraventricular nuclei with neurosecretion in rats. (2006)
  • Author(s): Kawasaki, M.Onaka, T.Nakazato, M.Saito, J.Mera, T.Hashimoto, H.Fujihara, H.Okimoto, N.Ohnishi, H.Nakamura, T., Ueta, Y.
  • Journal Title: Journal of Endocrinology 190(2) Pages: 213-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus. (2006)
  • Author(s): Mera T, Fujihara H, Kawasaki M, Hashimoto H, Saito T, Shibata M, Saito J, Oka T, Tsuji S, Onaka T, Ueta, Y.
  • Journal Title: Neuroscience 141(2) Pages: 1069-1086
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The hypothalamo-pituitary axis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase. (2006)
  • Author(s): Akasaka, S.Nomura, M.Nishii, H.Fujimoto, N.Ueta, Y.Tsutsui, M.Shimokawa, H.Yanagihara, N., Matsumoto
  • Journal Title: Brain Research 1089(1) Pages: 1-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The short chain sugar acid, 2-buten-4-olide, activates oxytocin-secreting neurons but not arginine vasopressin- secreting neurons in the hypothalamus of rats. (2006)
  • Author(s): Kawasaki, M.Yamaga, C.Onaka, T.Saito, J.Mera, T.Hashimoto, H.Fujihara, H.Okimoto, N.Ohnishi, H.Nakamura, T., Ueta, Y.
  • Journal Title: Brain Research 1086(1) Pages: 133-141
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cannabinoids modulate synaptic activity in the rat supraoptic nucleus. (2005)
  • Author(s): Soya, A., Serino, R., Fujihara, H., Onaka, T., Ozaki, Y., Saito, T., Nakamura, J., Ueta.Y.
  • Journal Title: Journal of Neuroendocrinology 17(9) Pages: 609-615
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms (2005)
  • Author(s): Morishita, T., Tsutsui, M., Shimokawa, H., Sanabai, K., Tasaki, H., Suda, O., Tanimoto, A., Wang, K.-Y., Ueta, Y., Sasaguri, Y., Nakashima, Y., Yanagihara, N
  • Journal Title: Proc Nat1 Acad Sci. U.S.A. 102(30) Pages: 10616-10621
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adrenomedullin protects rat cerebral endothelial cells from oxidant damage in vitro. (2005)
  • Author(s): Chen, L., Kis, B., Bujida, D.W., Yamashita, H., Ueta, Y.
  • Journal Title: Regulatory Peptides 130(1-2) Pages: 27-34
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of immediate early genes and vasopressin heteronuclear RNA in the paraventricular and supraoptic nuclei of rats after acuteosmotic stimulus (2005)
  • Author(s): Kawasaki, M., Yamaguchi, K., Saito, J., Ozaki, Y., Mera, T., Hashimoto, H., Fujihara, H., Okimoto, N., Ohnishi, H., Nakamura, T., Ueta.Y.
  • Journal Title: Journal of Neuroendocrinology 17(4) Pages: 227-237
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Centrally administered adrenomedullin 2 activates hypothalamic oxytocin-secreting neurons causing elevated plasma oxytocin level in rats. (2005)
  • Author(s): Hashimoto, H., Hyodo, S., Kawasaki, M., Mera, T., Chen, L., Soya, A., Saito, T., Fujihara, H., Higuchi, T., Takei, Y., Ueta.Y.
  • Journal Title: American Journal of Physiology 289(5) Pages: E753-761
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor. (2005)
  • Author(s): Hashimoto, H., Onaka, T., Kawasaki, M., Chen, L., Mera, T., Soya, A., Saito, T., Fujihara, H., Sei, H., Morita, Y., Ueta.Y.
  • Journal Title: Autonomic Neuroscience : Basic and Clinical 121(1-2) Pages: 16-25
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Induction of galanin-like peptide gene expression in the arcuate nucleus of the rat after acute but not chronic inflammatory stress. (2005)
  • Author(s): Saito, J., Ozaki, Y., Kawasaki, M., Ohnishi, H., Okimoto, N., Nakamura, T., Ueta.Y.
  • Journal Title: Molecular Brain Research 133(2) Pages: 233-241
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus. (2005)
  • Author(s): Nomura, M., Tsutsui, M., Shimokawa, H., Fujimoto, N., Ueta.Y., Morishita, T., Yanagihara, N., Matsumoto, T.
  • Journal Title: Neuroreport 16(4) Pages: 413-417
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transgenic expression of enhanced green fluorescent protein enables direct visualization for physiological studies of vasopressin neurons and isolated nerve terminals of the rat. (2005)
  • Author(s): Ueta, Y., Fujihara, H., Serino, R., Dayanithi, G., Ozawa, H., Matsuda, K., Kawata, M., Yamada, J., Ueno, S., Fukuda, A., Murphy, D.
  • Journal Title: Endocrinology 146(1) Pages: 406-413
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. (2005)
  • Author(s): Morishita, T.Tsutsui, M.Shimokawa, H.Sanabai, K.Tasaki, H.Suda, O.Tanimoto, A.Wang, K.-Y.Ueta, Y.Sasaguri, Y.Nakashima, Y., Yanagihara, N.
  • Journal Title: Proc Natl Acad Sci U.S.A. 102(30) Pages: 10616-10621
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adrenomedullin protects rat cerebral endothelial cells from oxidant damage in vitro. (2005)
  • Author(s): Chen, L.Kis, B.Bujida, D.W.Yamashita, H., Ueta, Y.
  • Journal Title: Regulatory Peptides 130(1-2) Pages: 27-34
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of immediate early genes and vasopressin heteronuclear RNA in the paraventricular and supraoptic nuclei of rats after acute osmotic stimulus. (2005)
  • Author(s): Kawasaki, M.Yamaguchi, K.Saito, J.Ozaki, Y.Mera, T.Hashimoto, H.Fujihara, H.Okimoto, N.Ohnishi, H.Nakamura, T., Ueta, Y.
  • Journal Title: Journal of Neuroendocrinology 17(4) Pages: 227-237
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Centrally administered adrenomedullin 2 activates hypothalamic oxytocin-secreting neurons causing elevated plasma oxytocin level in rats. (2005)
  • Author(s): Hashimoto, H.Hyodo, S.Kawasaki, M.Mera, T.Chen, L.Soya, A.Saito, T.Fujihara, H.Higuchi, T.Takei, Y., Ueta, Y.
  • Journal Title: American Journal of Physiology 289(5) Pages: E753-761
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor. (2005)
  • Author(s): Hashimoto, H.Onaka, T.Kawasaki, M.Chen, L.Mera, T.Soya, A.Saito, T.Fujihara, H.Sei, H.Morita, Y., Ueta, Y.
  • Journal Title: Autonomic Neuroscience : Basic and Clinical 121(1-2) Pages: 16-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of galanin-like peptide gene expression in the arcuate nucleus of the rat after acute but not chronic inflammatory stress. (2005)
  • Author(s): Saito, J.Ozaki, Y.Kawasaki, M.Ohnishi, H.Okimoto, N.Nakamura, T., Ueta, Y.
  • Journal Title: Molecular Brain Research 133(2) Pages: 233-241
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus. (2005)
  • Author(s): Nomura, M.Tsutsui, M.Shimokawa, H.Fujimoto, N.Ueta, Y.Morishita, T.Yanagihara, N., Matsumoto, T.
  • Journal Title: Neuroreport 16(4) Pages: 413-417
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transgenic expression of enhanced green fluorescent protein enables direct visualization for physiological studies of vasopressin neurons and isolated nerve terminals of the rat. (2005)
  • Author(s): Ueta, Y.Fujihara, H.Serino, R.Dayanithi, G Ozawa, H.Matsuda, K.Kawata, M.Yamada, J.Ueno, S.Fukuda, A., Murphy, D.
  • Journal Title: Endocrinology 146(1) Pages: 406-413
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cannabinoids modulate synaptic activity in the rat supraoptic nucleus. (2005)
  • Author(s): Soya, A.Serino, R.Fujihara, H.Onaka, T.Ozaki, Y.Saito, T.Nakamura, J., Ueta, Y.
  • Journal Title: Journal of Neuroendocrinology 17(9) Pages: 609-615
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potentiation by angiotensin II of spontaneous excitatory postsynaptic currents in rat supraoptic magnocellular neurons. (2004)
  • Author(s): Ozaki, Y., Soya, A., Nakamura, J., Matsumoto, T., Ueta.Y.
  • Journal Title: Journal of Neuroendocrinology 16 Pages: 871-879
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. (2004)
  • Author(s): Hanada, R., Teranishi, H., Pearson, J.T., Kurokawa, M., Hosoda, H., Fukushima, N., Fukue, Y., Serino, R., Fujihara, H., Ueta.Y., Ikawa, M., Okabe, M., Murakami, N., Shirai, M., Yoshimatsu, H., Kangawa, K., Kojima, M
  • Journal Title: Nature Medicine 10(10) Pages: 1067-1073
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Upregulation of corticotropin-releasing hormone gene expression in the paraventricular nucleus of cyclophosphamide-induced cystitis in male rats. (2004)
  • Author(s): Mineta, K., Nomura, M., Terado, M., Fujimoto, N., Sasaguri, T., Ueta, Y., Matsumoto, T.
  • Journal Title: Brain Research 1018(2) Pages: 193-200
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U. (2004)
  • Author(s): Yokota, M., Ozaki, Y., Sakamoto, F., Yamada, S., Saito, J., Fujihara, H., Ueta.Y.
  • Journal Title: Stress 7(2) Pages: 109-112
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Galanin-like peptide gene expression in the hypothalamus and posteriorpituitary of the obese fa/fa rat. (2004)
  • Author(s): Saito, J., Ozaki, Y., Kawasaki, M., Ohnishi, H., Okimoto, N., Nakamura, T., Ueta.Y.
  • Journal Title: Peptides 25(6) Pages: 967-974
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide. (2004)
  • Author(s): Chen, L., Hashida, S., Kitamura, K., Eto, T., Kangawa, K., Serino, R., Kis, B., Yamashita, H., Ueta.Y.
  • Journal Title: Peptides 25(4) Pages: 609-614
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Novel G-protein coupled receptor ligands and neurohypophysial hormones. (2004)
  • Author(s): Ueta, Y., Ozaki, Y., Saito, J.
  • Journal Title: Journal of Neuroendocrinology 16(4) Pages: 378-382
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats : possible involvement of central orexins on stress-activated central CRH neurons. (2004)
  • Author(s): Sakamoto, F., Yamada, S., Ueta.Y.
  • Journal Title: Regulatory Peptides 118(3) Pages: 183-191
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of the arginine vasopressin gene in response to salt loading in oxytocin gene knockout mice. (2004)
  • Author(s): Ozaki, Y., Nomura, M., Saito, J., Luedke, CE., Muglia, LJ., Matsumoto, T., Ogawa, S., Ueta, Y., Pfaff, DW.
  • Journal Title: Journal of Neuroendocrinology 16(1) Pages: 39-44
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U. (2004)
  • Author(s): Yokota, M.Ozaki, Y.Sakamoto, F.Yamada, S.Saito, J.Fujihara, H., Ueta, Y.
  • Journal Title: Stress 7(2) Pages: 109-112
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat. (2004)
  • Author(s): Saito, J.Ozaki, Y.Kawasaki, M.Ohnishi, H.Okimoto, N.Nakamura, T., Ueta, Y.
  • Journal Title: Peptides 25(6) Pages: 967-974
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Disassociated increases of adrenomedullin in the rat cerebrospinal fluid and plasma after salt loading and systemic administration of lipopolysaccharide. (2004)
  • Author(s): Chen, L.Hashida, S.Kitamura, K.Eto, T.Kangawa, K.Serino, R.Kis, B.Yamashita, H., Ueta, Y.
  • Journal Title: Peptides 25(4) Pages: 609-614
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel G-protein coupled receptor ligands and neurohypophysial hormones. (2004)
  • Author(s): Ueta, Y.Ozaki, Y., Saito, J.
  • Journal Title: Journal of Neuroendocrinology 16(4) Pages: 378-382
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Centrally administered orexin-A activates corticotrophin -releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats : possible involvement of central orexins on stress -activated central CRH neurons. (2004)
  • Author(s): Sakamoto, F.Yamada, S., Ueta, Y.
  • Journal Title: Regulatory Peptides 118(3) Pages: 183-191
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of the arginine vasopressin gene in response to salt loading in oxytocin gene knockout mice. (2004)
  • Author(s): Ozaki, Y.Nomura, M.Saito, J.Luedke, CE.Muglia, LJ.Matsumoto, T.Ogawa, S.Ueta, Y., Pfaff, DW.
  • Journal Title: Journal of Neuroendocrinology 16(1) Pages: 39-44
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potentiation by angiotensin II of spontaneous excitatory postsynaptic currents in rat supraoptic magnocellular neurons. (2004)
  • Author(s): Ozaki, Y.Soya, A.Nakamura, J.Matsumoto, T., Ueta, Y.
  • Journal Title: Journal of Neuroendocrinology 16 Pages: 871-879
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. (2004)
  • Author(s): Hanada, R.Teranishi, H.Pearson, J.T.Kurokawa, M.Hosoda, H.Fukushima, N.Fukue, Y.Serino, R.Fujihara, H.Ueta, Y.Ikawa, M.Okabe, M.Murakami, N.Shirai, M.Yoshimatsu, H.Kangawa, K., Kojima, M.
  • Journal Title: Nature Medicine 10(10) Pages: 1067-1073
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Upregulation of corticotropin-releasing hormone gene expression in the paraventricular nucleus of cyclophosphamide-induced cystitis in male rats. (2004)
  • Author(s): Mineta, K.Nomura, M.Terado, M.Fujimoto, N.Sasaguri, T.Ueta, Y., Matsumoto, T.
  • Journal Title: Brain Research 1018(2) Pages: 193-200
  • Description: 「研究成果報告書概要(欧文)」より