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2006 Fiscal Year Final Research Report Summary

Study on patho-epidemiology of malignant lymphoma in Japan

Research Project

Project/Area Number 16390105
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionOsaka University

Principal Investigator

AOZASA Katsuyuki  Osaka University, Graduate School of Medicine, professor, 医学系研究科, 教授 (30115985)

Co-Investigator(Kenkyū-buntansha) TOMITA Yasuhiko  Osaka University, Graduate School of Medicine, Associate professor, 医学系研究科, 助教授 (60263266)
TAKAKUWA Tetsuya  Osaka University, Graduate School of Medicine, Associate professor, 医学系研究科, 助教授 (40244933)
Project Period (FY) 2004 – 2006
Keywordsmalignant lymphoma / etiology / EB virus / rheumatoid arthritis / prognosis
Research Abstract

The study based on the cases with malignant lymphomas registered in the Osaka Lymphoma Study Group and the cases with pyothorax-associated lymphoma (PAL) and nasal NK/T-cell lymphoma (NKTCL). Malignant lymphomas developed in rheumatoid arthritis were also included. Epidemiological and molecular analysis were performed on these cases. The main findings obtained from these findings were as follows.
1. Case-control study in Japan(5 institutes), Korea (Yonsei Univ), and China (China Medical Univ) revealed that pesticides and chemical solvents were risk factors for development of NKTCL (Int J Cancer 2006).
2. PAL is an EBV-associated lymphoma. Loss of EBNA-2 one of EBV-coded latent genes, correlated with prognosis of PAL patients (Int J Cancer 2006).
3. It is known that lymphoproliferative disease (LPD) develop relative frequently in patients with rheumatoid arthritis (RA), in which methotrexate (MTX) administration for RA is supposed to be involved. Then we compared the RA-LPD with and without MT X medication, showing no fundamental differences between them. (J Rheum 2007).
4.Mutations of DNA mismatch repair genes, ATM, ATR, and MRE 11, in 50 cell lines from lymphoid leukemias and lymphomas, were examined. Mutations of ATM and MRE 11 were occasionally found. These mutations might cause genome instability, and finally result in lymphoid neoplasias. (Cancer Sci 2006).

  • Research Products

    (11 results)

All 2007 2006 2005 2004

All Journal Article (10 results) Book (1 results)

  • [Journal Article] Pre B cell leukemia transcription factors (PBX1) regulates expression of valosin-containing protein(VCP)2007

    • Author(s)
      Qiu Y, Aozasa K, et al.
    • Journal Title

      Am J Pathol 170

      Pages: 152-159

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Pre B cell leukemia transcription factors (PBX1) regulates expression of valosin-containing protein (VCP).2007

    • Author(s)
      Qiu Y, Aozasa K, et al.
    • Journal Title

      Am J Pathol 170

      Pages: 152-159

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Life-style and environmental factors in the development of nasal NK/T-cell lymphoma.2006

    • Author(s)
      Xu JX, Aozasa K, et al.
    • Journal Title

      Int J Cancer 120

      Pages: 406-410

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Life-style and environmental factors in the development of nasal NK/T-cell lymphoma.2006

    • Author(s)
      Xu J-X, Aozasa K, et al.
    • Journal Title

      Int J Cancer 120

      Pages: 406-410

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Alterations of DNA damage-response genes ATM and ATR in cell lines from pyothorax-associated lymphoma.2005

    • Author(s)
      Liu A, Aozasa K, et al.
    • Journal Title

      Lab Invest 85

      Pages: 436-446

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prognostic significance of BACH2 expression in diffuse large B-cell lymphoma.2005

    • Author(s)
      Sakane-Ishikawa E, Aozasa K, et al.
    • Journal Title

      J Clin Oncol 23

      Pages: 8012-8017

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji).2004

    • Author(s)
      Takakuwa T, Aozasa K, et al.
    • Journal Title

      Am J Pathol 164

      Pages: 967-974

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Epstein-Barr virus(EBV)-encoded RNA (EBER) promotes growth of EBV-infected T-cells through interleukia-9 induction.2004

    • Author(s)
      Yang L, Aozasa K, et al.
    • Journal Title

      Cancer Res 64

      Pages: 5332-5337

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Integration of Epstein-Barr virus into Chromosome 6q15 of Burkitt lymphoma cell line (Raji).2004

    • Author(s)
      Takakuwa T, Aozasa K, et al.
    • Journal Title

      Am J Pathol 164

      Pages: 967-974

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Epstein-Barr virus (EBV)-encoded RNA (EBER) promotes growth of EBV-infected T-cells through interleukia-9 induction.2004

    • Author(s)
      Yang L, Aozasa K, et al.
    • Journal Title

      Cancer Res 64

      Pages: 5332-5337

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 組織病理アトラス2005

    • Author(s)
      青笹 克之
    • Total Pages
      22
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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