2006 Fiscal Year Final Research Report Summary
Molecular pathologenesis of gastric MALT lymphomas and their response to eradiacation of H. pylori
| Project/Area Number |
16390106
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Okayama University |
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Principal Investigator |
YOSHINO Tadashi Okayama University, Department of Pathology, Professor and Chairman, 大学院医歯薬学総合研究科, 教授 (70183704)
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| Co-Investigator(Kenkyū-buntansha) |
OKA Takashi Okayama University, Department of Pathology, Lecturer, 大学院医歯薬学総合研究科, 助手 (50160651)
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| Project Period (FY) |
2004 – 2006
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| Keywords | malignant lymphoma / MALT lymphoma / stomach / H. pylori / eradication / SHP-1 / methylation / tumor-suppresor gene |
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| Research Abstract |
Responsiveness of gastric MALT lymphomas to eradication of H. pylori was related to titers of serum anti-HSP 60 antibody. SHP-1 was positive in some resistant patients, whereas patients in complete remission was negative for SHP-1. Peripheral mononuclear cells taken from patients of gastric MALT lymhoma express high level of CD4OL and produced IL4 at the presence of HSP60 or H.pylori which was contrast to those from patients with chronic gastritis and ulcers and healthy donors that produce INF γ. Methylation of SHP1 was low level in MALT lymphomas, intermediate level in MALT lymphoma associated with diffuse large cell lymphoma, and high level in pure DLBCLs. Moreover, by the analysis of 10 tumor-suppressor genes, 86% of MALT lymphomas showed methylation in at least one supressor gene, whereas cases after eradiation showed 46% and remission cases showed only 14%. We also examined p27, p53, Ki67 antigen expressions, and all MALT lymphomas were positive for p27, negative for p53, and low MIB-1 index. DLBCLs were negative for p27, positive for p53 and high MIB-1 index. Interestingly, MALT-lymhoma component associated with DLBCL lacked p27. This findings suggested loss of p27 may be related to high-grade progression which is closely related to resistance of eradication.
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Research Products
(42 results)
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[Journal Article] Epstein-Barr virus involvement is a predictive factor for the resistance to chemoradiotherapy of gastric diffuse large B-cell lymphoma.2006
Author(s)
Yoshino T, Nakamura S, Matsuno Y, Ochiai A, Yokoi T, Kitadai Y, Suzumiya J, Tobinai K, Kobayashi Y, Oda I, Mera K, Ohtsu A, Ishikura S
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Journal Title
Cancer Sci. 79・2
Pages: 163-166
Description
「研究成果報告書概要(和文)」より
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[Journal Article] p27(Kip1) is detected on most gastric MALT lymphomas, but not large cell lymphomas.2006
Author(s)
Sato H, Sato Y, Ichimura K, Oka T, Kondo E, Tanaka T, Kondo T, Ohara N, Takahashi K, Yoshino T
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Journal Title
J Clin Exp Hematop. 46・1
Pages: 25-30
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Deviated VH4 immunoglobulin gene usage is found among thyroid mucosa-associated lymphoid tissue lymphomas, similar to the usage at other sites, but is not found in thyroid diffuse large B-cell lymphomas.2006
Author(s)
Sato Y, Nakamura N, Nakamura S, Sakugawa S, Ichimura K, Tanaka T, Ohara N, Oka T, Kondo E, Yoshino T
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Journal Title
Mod Pathol. 19・12
Pages: 1578-1584
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Follicular lymphoma frequently originates in the salivary gland.2006
Author(s)
Nakamura S, Ichimura K, Sato Y, Nakamura S, Nakamine H, Inagaki H, Sadahira Y, Ohshima K, Sakugawa S, Kondo E, Yanai H, Ohara N, Yoshino T
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Journal Title
Pathol Int. 56・10
Pages: 576-583
Description
「研究成果報告書概要(和文)」より
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[Journal Article] 胃MALTリンパ腫の除菌後の経過と分子基盤2004
Author(s)
吉野 正, 市村浩一, 佐藤由美子, 田中健大, 佐久川純枝, 田中晋一, 山崎理恵, 中村聡子, 小田和歌子, 中谷陽子, 高畑浩之
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Journal Title
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Serum antibodies to Helicobacter pylori and its heat-shock protein 60 correlate with the response of gastric mucosa-associated lymphoid tissue lymphoma to eradication of H. pylori.2004
Author(s)
Takenaka R, Yokota K, Mizuno M, Okada H, Toyokawa T, Yamasaki R, Yoshino T, Sugiyama T, Asaka M, Shiratori Y, Oguma K
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Journal Title
Helicobacter 9・3
Pages: 194-200
Description
「研究成果報告書概要(和文)」より
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