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2006 Fiscal Year Final Research Report Summary

Molecular pathology of the functional differentiation of the pituitary adenoma

Research Project

Project/Area Number 16390110
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionTokai University

Principal Investigator

OSAMURA Yoshiyuki  Tokai University, School of Medicine, Professor, 医学部, 教授 (10100992)

Co-Investigator(Kenkyū-buntansha) UMEMURA Shinobu  Tokai University, School of Medicine, Associate Professor, 医学部, 助教授 (20276794)
TAKEKOSHI Susumu  Tokai University, School of Medicine, Associate Professor, 医学部, 助教授 (70216878)
KAJIWARA Hiroshi  Tokai University, School of Medicine, Assistant Professor, 医学部, 講師 (20317754)
KIMURA Minoru  Tokai University, School of Medicine, Professor, 医学部, 教授 (10146706)
TERAMOTO Akira  Nippon Medical School, School of Medicine, Professor, 医学部, 教授 (60231445)
Project Period (FY) 2004 – 2006
KeywordsPituitary / αSU / FOXL2 / Adenoma
Research Abstract

[AIM] Many transcription factors play important roles in function and differentiation of the human pituitary adenomas. Forkhead box transcription factor L2, Fox12, is expressed during mouse pituitary development and co-localizes with expression of the glycoprotein hormone a subunit (aGSU). In addition, FOXL2 regulates expression of the aGSU gene in cell culture. To elucidate the functional role of FOXL2 in human pituitary, we detected the localization and expression of FOXL2 in normal human pituitaries and various types of its adenomas.
[MATERIALS AND METHODS] The human pituitary adenomas were obtained by trans-sphenoidal surgery from 66 patients. Two normal adult pituitaries were obtained from the autopsies of non-endocrine cases. The localization of FOXL2 and pituitary hormones in these pituitary patients was studied by immunohistochemical staining. The quantitative analysis of FOXL2 protein was detected by using immunoblotting.
[RESULTS AND DISCUSSION] FOXL2 was localized immunohistochemically in many of gonadotropin producing adenomas (Gn-omas), and in about 20% of normal pituitaries that also co-expressed aGSU.
These results are consistent with the idea that FOXL2 plays a role in αGSU expression in human pituitary adenomas. Future studies with gain and loss of function animal models will be important to assess the function of FOXL2 in establishing and maintaining differentiated αGSU expressing cells.

  • Research Products

    (12 results)

All 2006

All Journal Article (12 results)

  • [Journal Article] FOXL2 in the pituitary : molecular genetic, and developmental analysis.2006

    • Author(s)
      Ellsworth BS et al.
    • Journal Title

      Molecular Endocrinology 20・11

      Pages: 2796-2805

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Immunonegative "null cell" adenomas and gonadotropin (Gn) subunit (SUs) immunopositive adenomas share frequent expression of multiple transcription factors.2006

    • Author(s)
      Ishii Y. et al.
    • Journal Title

      Endocrine Pathology 17・1

      Pages: 35-43

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effect of mitotane on pituitary corticotrophs in clinically normal dogs.2006

    • Author(s)
      Taoda T. et al.
    • Journal Title

      American Journal of veterinary research 67・8

      Pages: 1385-1394

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] PTTG overexpression is correlated with angiogenesis in human pituitary adenomas.2006

    • Author(s)
      Minematsu T. et al.
    • Journal Title

      Endocrine Pathology 17・2

      Pages: 143-153

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Phosphorylation of cAMP response element binding protein (CREB) as a marker of hypoxia in pituitary adenoma.2006

    • Author(s)
      Morimoto D. et al.
    • Journal Title

      Journal of neuro-oncology 79・2

      Pages: 143-150

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Impaired regulation of gonadotropins leads to the atrophy of the female reproductive system in klotho-deficient mice.2006

    • Author(s)
      Toyama R. et al.
    • Journal Title

      Endocrinology 147・1

      Pages: 120-129

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] FOXL2 in the pituitary : molecular genetic, and developmental analysis.2006

    • Author(s)
      Ellswor th BS
    • Journal Title

      Molecular Endocrinology 20-11

      Pages: 2796-2805

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Immunonegative "null cell" adenomas and gonadotropin (Gn) subunit (SUs) immunopositive adenomas share frequent expression of multiple transcription factors.2006

    • Author(s)
      Ishii Y
    • Journal Title

      Endocrine Pathology 17-1

      Pages: 35-43

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of mitotane on pituitary corticotrophs in clinically normal dogs.2006

    • Author(s)
      Taoda T
    • Journal Title

      American Journal of veterinary research 67-8

      Pages: 1385-1394

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] PTTG overexpress ion is correlated with angiogenesis in human pituitary adenomas.2006

    • Author(s)
      Minematsu T
    • Journal Title

      Endocrine Pathology 17-2

      Pages: 143-153

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Phosphorylation of cAMP response element binding protein (CREB) as a marker of hypoxia in pituitary adenoma.2006

    • Author(s)
      Morimoto D
    • Journal Title

      Journal of neuro-oncology 79-2

      Pages: 143-150

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Impaired regulation of gonadotropins leads to the atrophy of the female reproductive system in klotho-deficient mice.2006

    • Author(s)
      Toyama R
    • Journal Title

      Endocrinology 147-1

      Pages: 120-129

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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