2007 Fiscal Year Final Research Report Summary
Molecular status of RBICCI in various disea,and trial for the clinical application
| Project/Area Number |
16390164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
OKABE Hidetoshi Shiga University of Medical Science, Department of Clinical Labaratory Medicine, Professor (70079713)
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| Co-Investigator(Kenkyū-buntansha) |
CHANO Tokuhiro Shiga University of Medical Science, Department of Clinical Laboratory Medicine, Assistant Professor (40346028)
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| Project Period (FY) |
2004 – 2007
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| Keywords | RB1CC1 / mTOR / RB1 / p53 / cancer / Alzheimer / TSC / hSNF5 / INT1 |
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| Research Abstract |
To clarify the molecular status of RB1CC1 (RB1-inducible coiled-coil 1) in various human diseases, we started this project, and have intended to apply the molecular pathways into clinical medicine.
In a consequence, we identified that RB1CC1 insufficiency resulted in mTOR signaling repression through unbalanced TSC1 abundance, induced neuronal atrophy, and then were involved in the pathogenesis of Alzheimer's disease.
More recently, our study also has demonstrated that RB1CC1 is a novel mediator connecting the RB1 and p53 pathways, and that the combined evaluation of RB1CC1 and p53 status will provide a routine, accurate prognostic test for patients with breast cancer.
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[Journal Article] Target specificities of estrogen receptor-related receptors : analysis of binding sequences and identification of rb 1-inducible coiled-coil 1(rblccl) as a target gene2007
Author(s)
Alder, MH, Chano, T., Okabe, H., Yamaguchi, T., Hirose, F., Osumi, T
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Journal Title
J Biochem 143(3)
Pages: 395-406
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Suppression of viral replication by stress-inducible GADD34 protein via, the mammalian serine/threonine protein kinase mTOR pathway2007
Author(s)
Minami, K., Tambe, Y., Watanabe, R., Isono, T., Haneda, M., Isobe, K.,Kobayashi, T., Hino, O., Okabe, H., Chano, T., Inoue, H
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Journal Title
J Virol 81(20)
Pages: 11106-15
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] GADD34 induces p21 expression and cellular senescence2007
Author(s)
Minami, K., Inoue, H., Terashita, T., Kawakami, T., Watanabe, R., Haneda, M., Isobe, K., Okabe, H., Chano, T
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Journal Title
Oncol Rep 17(6)
Pages: 1481-5
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress2007
Author(s)
Watanabe, R., Tambe, Y., Inoue, H., Isono, T., Haneda, M., Isobe, K., Kobayashi, T., Hino, O., Okabe, H., Chano, T
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Journal Title
Int J Mol Med 19(3)
Pages: 475-83
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Neuromuscular abundance of RBICC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation2006
Author(s)
Chano, T., Saji, M., Inoue, H., Minami, K., Kobayashi, T., Hino, O., Okabe, H
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Journal Title
Int J Mol Med 18(3)
Pages: 425-32
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma2006
Author(s)
Kawakami, T., Chano, T., Minami, K., Okabe, H., Okada, Y., Okamoto, K
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Journal Title
Hum Mol Genet 15(6)
Pages: 821-30
Description
「研究成果報告書概要(欧文)」より
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[Presentation] RBICC1 enhances RB pathway in cooperation with hSNF5 and p532007
Author(s)
Ikebuchi, K., Chano, T., Isono, T., Inoue, H., Okabe, H
Organizer
JCA
Place of Presentation
Yokohama, Japan
Year and Date
20071003-05
Description
「研究成果報告書概要(欧文)」より
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