2007 Fiscal Year Final Research Report Summary
Epidemiologic study of the association between job stress and cancer incidence and its mechanisms
| Project/Area Number |
16390170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | The University of Tokyo (2006-2007)
Okayama University (2004-2005) |
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Principal Investigator |
KAWAKAMI Norito The University of Tokyo, Graduate School of Medicine, Professor (90177650)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Akizumi University of Occupational and Environmental Medicine, Occupational Health Training Center, Professor (10289366)
SHIMAZU Akihito The University of Tokyo, Graduate School of Medicine, Associate Professor (80318724)
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| Project Period (FY) |
2004 – 2007
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| Keywords | cancer / incidence / risk factor / stress / immune function / healthy lvfestvle |
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| Research Abstract |
The present study project investigated the association between job stressors and cancer incidence, as well as its mechanisms, by conducting two prospective cohort studies (old and new cohort studies) and smaller prospective and cross-sectional epidemiologic studies on the mediators between job stressors and cancer incidence (physiological parameters, such as immune functions, oxidative DNA damage, and health-related behaviors such as diet).
The project tested the following associations: (1) the association of job stressors based on the two major theories of job stress, i.e., "demand-control-support model" and "effort-reward imbalance model", with all cancer incidence (as well as site-specific cancer incidences), (2) the association of other psychosocial factors at work with all cancer incidence, and (3) the association of the job stressors with physiological parameters (immune functions, oxidative DNA damage) and health-related behaviors (smoking, drug, and diet).
As the results of the present research project, it is suggested that the job stressors increase the all-cancer incidence. Part of the association seems to be explained by oxidative DNA damage caused by the job stressors. Diet and other health-related behaviors may not play a major role in connecting the job stressors and cancer incidence.
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[Journal Article] Job strain, worksite support, and nutrient intake among employed Japanese men and women2006
Author(s)
Kawakami N, Tsutsumi A, Haratani T, Kobayashi F, Ishizaki M, Hayashi T, Fujita O, Aizawa Y, Miyazaki S, Hiro H, Masumoto T, Hashimoto S, Araki S
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Journal Title
J Epidemiol 16(2)
Pages: 79-89
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Occupational class and exposure to job stressors among employed men and women in Japan.2004
Author(s)
Kawakami N, Haratani T, Kobayashi F, Ishizaki M, Hayashi T, Fujita O, Aizawa Y, Miyazaki S, Hiro H, Masumoto T, Hashimoto S, Araki S.
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Journal Title
J. Epidemiol. 14(6)
Pages: 204-211
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Occupational class and exposure to job stressors among employed men and women in Japan2004
Author(s)
Kawakami N, Haratani T, Kobayashi F, Ishizaki M, Hayashi T, Fujita O, Aizawa Y, Miyazaki S, Hiro H, Masumoto T, Hashimoto S, Araki S
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Journal Title
J Epidemiol 14(6)
Pages: 204-211
Description
「研究成果報告書概要(欧文)」より
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