2006 Fiscal Year Final Research Report Summary
A large-scale cohort study of Kawasaki disease patients to investigate the prognosis
| Project/Area Number |
16390185
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | JICHI MEDICAL UNIVERSITY |
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Principal Investigator |
NAKAMURA Yosikazu JICHI MEDICAL UNIVERSITY, School of Medicine, Department of Public Health, Professor, 医学部, 教授 (50217915)
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| Co-Investigator(Kenkyū-buntansha) |
OKI Izumi JICHI MEDICAL UNIVERSITY, School of Medicine, Department of Public Health, Assistant Professor, 医学部, 講師 (50296092)
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| Project Period (FY) |
2004 – 2006
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| Keywords | Mucocutaneous lymph node syndrome / long-term prognosis / mortality rate / follow-up / Japan |
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| Research Abstract |
Background : long-term prognosis of those with a history of Kawasaki disease is still unknown.
Methods : Between July 1982 and December 1992, 52 collaborating hospitals collected data on all patients having a new definite diagnosis of Kawasaki disease. Patients were followed-up until December 31, 2004 or their death. The expected number of deaths was calculated from Japanese vital statistics data and compared with the observed number as standardized mortality ratios (SMR : the observed number of deaths divided by the expected number of deaths based on the vital statistics in Japan).
Results : Of 6,576 patients enrolled, 36 (27 males and 9 females) had died by the last day of 2004. The SMR was 1.14 (95% confidence interval : 0.80-1.57). In spite of the high SMRs during the acute phase, the mortality rate was not high after the acute phase for the entire group of patients. Although the SMR after the acute phase was 0.71 for those without cardiac sequelae, 10 males (but none of the females) with cardiac sequelae died during the observed period ; and the SMR for the male group with cardiac sequelae was 2.55 (95% confidence interval : 1.23-4.70).
Conclusions : The mortality rate among males with cardiac sequelae due to Kawasaki disease was significantly higher than in the general population. On the other hand, the mortality rates for females with the sequelae and both males and females without sequelae were not elevated.
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