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2006 Fiscal Year Final Research Report Summary

Establishment of diagnostic and treatment strategies for chronic fatigue syndrome

Research Project

Project/Area Number 16390199
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNagoya University

Principal Investigator

BAN Nobutaro  University Hospital, Professor, 医学部附属病院, 教授 (40218673)

Co-Investigator(Kenkyū-buntansha) ROKUTAN Kazuhito  Tokusima University Graduate School, Institute of Health Biosciences, Professor, 大学院ヘルスバイオサイエンス研究部, 教授 (10230898)
Project Period (FY) 2004 – 2006
Keywordsfatigue / chronic fatigue / dia gnosis / treatment / cDNA chip / microarray / Q fever / HHV
Research Abstract

We performed the following investigations to explore unknown mechanism underling the chronic fatigue syndrome (CFS) syndrome and to find tools for objective assessment from 2004 to 2006.
SUBJECTS : Sixty patients with the chief complaint of general fatigue
MEASUREMENTS: Clinical information, laboratory data including serum hormones and antibodies against human herpes viruses (HHV 6 and 7) or Coxiella burnetti, and mRNA expression of stress-responsive genes in peripheral blood cells.
MPARTICIPTED CLINICIANS: All patients were clinical assessed by general internists as well as psychiatrist.
TREATMENTS: All patients were treated by traditional herbal medicine according to the patients clinical conditions ‘Sho'.
RESULTS:
1) Increased HHV6 and HHV7 titers were noted in 4 patients, but they were not particularly related with CFS.
2) No patient showed the increased antibodies against Coxiella burnetti.
3) Clinically patients with the chief complaint of general fatigue were divided into 4 groups: CFS, psychiatric disease, organic disease, and undetermined etiology. Amongst 26 patients who were fully investigated CFS 8 cases, psychiatric disease 11 cases, organic disease 4 cases, and undetermined etiology 3 cases.
4) Nine genes that may be useful for detection of pathological responses in CFS patients and for differential diagnosis of this syndrome were determined.
5) ‘Sho' did not shoe any particular pattern.

  • Research Products

    (12 results)

All 2006 2005

All Journal Article (11 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 疲労・倦怠感を主訴とする患者に対する診断の手引き.2006

    • Author(s)
      伴信太郎
    • Journal Title

      総合臨床 55

      Pages: 76-80

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 慢性疲労症候群(疑)で来院した患者の病態分類.2006

    • Author(s)
      西城卓也, 伴信太郎
    • Journal Title

      心療内科 10

      Pages: 438-442

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DNAチップを用いた診断法.2006

    • Author(s)
      六反一仁, 森田恭子, 増田清士, 河合智子, 関山敦夫
    • Journal Title

      総合臨床 55

      Pages: 65-69

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ストレスの新しい評価技術の開発とその臨床応用.2006

    • Author(s)
      六反一仁
    • Journal Title

      Gout and Nucleic Acid Metabolism 30

      Pages: 239

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Guideline to approach the patients with the chief complaint of general fatigue. (n Japanese)2006

    • Author(s)
      Nobutaro Ban
    • Journal Title

      Clinic All-round 55

      Pages: 76-80

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] How to evaluate the patients with general fatigue. (in Japanese)2006

    • Author(s)
      Takuya Saiki, Nobutaro Ban
    • Journal Title

      Psychosomatic medicine 10

      Pages: 438-442

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Application of DNA chip for diagnosis of chronic fatigue syndrome. (in Japanese)2006

    • Author(s)
      Kyoko Morita, Kazuhito Rokutan, et al.
    • Journal Title

      Clinic All-round 55

      Pages: 65-69-80

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of new stress assessment methods and its clinical application. (in Japanese)2006

    • Author(s)
      Kazuhito Rokutan
    • Journal Title

      Gout and Nucleic Acid Metabolism 30

      Pages: 239

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression analysis of psychological stress-associated genes in peripheral blood leukocytes.2005

    • Author(s)
      Kyoko Morita, Kazuhito Rokutan, et al.
    • Journal Title

      Neuroscience Letters 381

      Pages: 57-62

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ストレスと神経・内分泌ネットワーク.2005

    • Author(s)
      森田恭子, 関山敦夫, 六反一仁
    • Journal Title

      脳と神経 57

      Pages: 397-406

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Stress and neuro-endocrine network. (in Japanese)2005

    • Author(s)
      Kyoko Morita, Kazuhito Rokutan, et al.
    • Journal Title

      Brain and Nerve 57

      Pages: 397-406

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] 慢性疲労症候群の診断方法2006

    • Inventor(s)
      伴信太郎,他
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      特願2006-054414
    • Filing Date
      2006-03-01
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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