Therapeutic angiogenesis to ischemic heart disease by cell transplantation

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 16390220
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Shinshu University
• Principal Investigator: IKEDA Uichi Shinshu University, Department of Organ Regeneration, Professor, 大学院医学系研究科, 教授 (30221063)
• Co-Investigator(Kenkyū-buntansha): AMANO Jun Shinshu University, Department of Surgery, Professor, 医学部, 教授 (20138283) ; TAKAHASHI Masafumi Shinshu University, Department of Organ Regeneration, Associate Professor, 大学院医学系研究科, 助教授 (40296108) ; ISE Hirohiko Shinshu University, Department of Organ Regeneration, Assistant Professor, 大学院医学系研究科, 助手 (10324253)
• Project Period (FY): 2004 – 2006
• Keywords: regeneration / atherosclerosis / myocardial infarction / bone marrow / angiogenesis

Research Abstract

We have previously reported the effectiveness and safety of therapeutic angiogenesis by transplantation of autologous bone marrow mononuclear cells to ischemic limbs (Lancet 2002). In this study, we investigated whether transplantation of bone marrow-derived endothelial progenitor cells (EPCs) would also be effective in patients with ischemic heart disease. Bone marrow-derived EPCs were transplanted to the myocardium in patients with ischemic heart disease ; They received bone marrow-derived CD34^+ cell transplantation into ungraftable regions of the left ventricle with concomitant coronary artery bypass grafts (hybrid therapy). Before and 1 month after cell transplantation, we assessed the regional blood flow by single photon emission computed tomography (SPECT). The blood flow in the EPC-transplanted region as well as the grafted region was significantly increased at 1 month after cell transplantation. No side effects were observed. In this study, we demonstrated that autologous transplantation of bone marrow-derived EPCs represents a new and promising strategy for clinical application designed to revascularize the ischemic myocardium

Research Products

• [Journal Article] M-CSF accelerates neointimal formation in the early phase after vascular injury in mice : the critical role of the SDF-1-CXCR4 system. (2007)
  • Author(s): Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U.
  • Journal Title: Arterioscler Thromb Vase Biol 27 Pages: 283-289
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: the critical role of the SDF-1-CXCR4 system. (2007)
  • Author(s): Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U.
  • Journal Title: Arterioscler Thromb Vasc Biol 27 Pages: 283-289
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cardiac overexpression of MCP-1 in transgenic mice prevents cardiac dysfunction and remodeling after myocardial infarction. (2006)
  • Author(s): Morimoto H, Takahashi M, Izawa A, Ise H, Hongo M, Kolattukudy PK, Ikeda U
  • Journal Title: Circ Res 99 Pages: 891-899
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of liver regenerative therapy using glycoside-modified bone marrow cells. (2006)
  • Author(s): Misawa R, Ise H, Takahashi M, Morimoto H, Kobayashi E, Miyagawa S, Ikeda U
  • Journal Title: Biochem Biophys Res Commun 342 Pages: 432-440
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] G-CSF accelerates reendothelialization and reduces neointimal formation after vascular injury in mice. (2006)
  • Author(s): Yoshioka T, Takahashi M, Shiba Y, Suzuki C, Morimoto H, Izawa A, Ise H, Ikeda U
  • Journal Title: Cardiovasc Res 70 Pages: 61-69
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Therapeutic potential of endothelial progenitor cells for cardiovascular diseases. (2006)
  • Author(s): Jia L, Takahashi M, Yoshioka T, Morimoto H, Ise H, Ikeda U
  • Journal Title: Current Vascular Pharmacology 4 Pages: 59-65
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of liver regenerative, therapy using glycoside-modified bone marrow cells (2006)
  • Author(s): Misawa R, Ise H, Takahashi M, Morimoto H, Kobayashi E, Miyagawa S, Ikeda U
  • Journal Title: Biochem Biophys Res Commun 342 Pages: 432-440
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] G-CSF accelerates reendothelialization and reduces neointimal formation after vascular injury in mice (2006)
  • Author(s): Yoshioka T, Takahashi M, Shiba Y, Suzuki C, Morimoto H, Izawa A, Ise H, Ikeda U
  • Journal Title: Cardiovasc Res 70 Pages: 61-69
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Therapeutic potential of endothelial progenitor cells for cardiovascular diseases (2006)
  • Author(s): Jia L, Takahashi M, Yoshioka T, Morimoto H, Ise H, Ikeda U
  • Journal Title: Current Vascular Pharmacology 4 Pages: 59-65
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Repair of infarcted myocardium mediated by transplanted bone marrow-derived CD34^+ stem cells in a nonhuman primate model (2005)
  • Author(s): Yoshioka T, Ageyama N, Shibata H, Yasu T, Misawa Y, Takeuchi K, Matsui K, Yamamoto K, Terao K, Shimada K, Ikeda U, Ozawa K, Hanazono Y
  • Journal Title: Stem Cells 23 Pages: 355-364
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Repair of infracted myocardium mediated by transplanted bone marrow-derived CD34^+ stem cells in a nonhuman primate model (2005)
  • Author(s): Yoshioka T, Ageyama N, Shibata H, Yasu T, Misawa Y, Takeuchi K, Matsui K, Yamamoto K, Terao K, Shimada K, Ikeda U, Ozawa K, Hanazono Y
  • Journal Title: Stem Cells 23 Pages: 355-364
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Annual Review循環器科(虚血肢に対する末梢幹細胞移植) (2006)
  • Author(s): 鈴木智裕, 高橋将文, 吉岡徹, 池田宇一
  • Total Pages: 359-365
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より