Integrated comparison among lung histology of human early emphysema, clinical parameters, and mechanics and model animals

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 16390234
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: MURO Shigeo Kyoto University, DEPARTMENT OF MEDICINE, ASSISTANT PROFESSOR (60344454)
• Co-Investigator(Kenkyū-buntansha): SAKAI Hiroaki KYOTO UNIVERSITY, DEPARTMENT OF MEDICINE, ASSISTANT PROFESSOR (50362489) ; MISHIMA Michiaki KYOTO UNIVERSITY, DEPARTMENT OF MEDICINE, PROFESSOR (60190625)
• Project Period (FY): 2004 – 2007
• Keywords: COPD / airway remodeling / emphysema / inflammation / computed tomography / genetics / pulmonary function / morphology

Research Abstract

We have been collecting human surgical lung specimen and lung tissues from animal model of COPD/emphysema. From the evaluation of morphological analysis, mechanical properties, and inflammation, we have shown the mechanism for the deterioration of COPD. Our prospective clinical study also showed the new associating factor, GERD, for the COPD exacerbation.

Research Products

• [Journal Article] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice. (2008)
  • Author(s): Sato A, Hoshino Y, Hara T, Muro S, et. al.
  • Journal Title: J Pharmacol Exp Ther. 325(2) Pages: 380-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography. (2008)
  • Author(s): Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, et. al.
  • Journal Title: Respirology 13(3) Pages: 372-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography (2008)
  • Author(s): Ohara, T., Hirai, T., Sato, S., Terada, K., Kinose, D., Haruna, A., Marumo, S., Nishioka, M., Ogawa, E., Nakano, Y., Hoshino, Y., Ito, Y., Matsumoto, H., Niimi, A., Mio, T., Chin, K., Muro, S., Mishima, M
  • Journal Title: Respirology 13(3) Pages: 372-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice (2008)
  • Author(s): Sato, A., Hoshino, Y., Ham, T., Muro, S., Nakamura, H., Mishima, M., Yodoi, J
  • Journal Title: J Pharmlacol Exp Tiler 325(2) Pages: 380-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Morphological mechanism of the development of pulmonary emphysema in klotho mice. (2007)
  • Author(s): Sato A, Hirai T, Imura A, Kita N, Iwano A, Muro S, et. al.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 2361-2365
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Morphological mechanism of the development of pulmonary emphysema in klotho mice (2007)
  • Author(s): Sato, A., Hirai, T., Imura, A., Kita, N., Iwano, A., Muro, S., Nabeshima, Y., Suki, B., Mishima, M
  • Journal Title: Proc Nat : Acad Sci USA 104 Pages: 2361-2365
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD. (2006)
  • Author(s): Ohara T, Hirai T, Sato S, Sato A, Nishioka M, Muro S, Mishima M
  • Journal Title: Respirology 11 Pages: 579-585
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] High sensitivity C-reactive protein in asthma. (2006)
  • Author(s): Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, Jinnai M, Muro S, et. al.
  • Journal Title: Eur Respir J 27 Pages: 908-912
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prognosis of cough variant asthma: a retrospective analysis. (2006)
  • Author(s): Matsumoto H, Niimi A, Takemura M, Ueda T, Tabuena R, Yamaguchi M, Matsuoka H, Hirai T, Muro S, et. al.
  • Journal Title: J Asthma 43 Pages: 131-135
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of small airways in asthma: investigation using high-resolution computed tomography. (2006)
  • Author(s): Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, et. al.
  • Journal Title: J Allergy Clin Immunol 118 Pages: 1019-1025
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] COPDの病態解析と治療法開発・治療評価への挑戦 CT画像解析・チオレドキシン創薬・アウトカムスタディを通して. (2006)
  • Author(s): 三嶋理晃、中野恭幸、西村浩一、室繁郎, 他
  • Journal Title: 最新医学 61 Pages: 118-175
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of small airways in asthma : investigation using high-resolution computed tomography (2006)
  • Author(s): Ueda, T., Niimi, A., Matsumoto, H., Takemura, M., Hirai, T., Yamaguchi, M., Matsuoka, H., Jinnai, M., Muro, S., Chin, K., Mishima, M
  • Journal Title: J Allergy Clin Immunol 118 Pages: 1019-1025
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prognosis of cough variant asthma : a retrospective analysis (2006)
  • Author(s): Matsumoto, H., Niimi, A., Takemura, M., Ueda, T., Tabuena, R., Yamaguchi, M., Matsuoka, H., Hirai, T., Muro, S., Ito, Y., Mio, T., Chin, K., Nishiyama, H., Mishima, M
  • Journal Title: J Asthma 2006 43 Pages: 131-135
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High sensitivity C-reactive protein in asthma (2006)
  • Author(s): Takemura, M., Matsumoto, H., Niimi, A., Ueda, T., Matsuoka, H., Yamaguchi, M., Jinnai, M., Mum, S., Hirai, T., Ito, Y., Nakamura, T., Mio, T., Chin, K., Mishima, M
  • Journal Title: Eur Respir J 27 Pages: 908-912
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD (2006)
  • Author(s): Ohara, T., Hirai, T., Sato, S., Sato, A., Nishioka, M., Muro, S., Mishima, M
  • Journal Title: Respirology 11 Pages: 579-585
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema. (2005)
  • Author(s): Ito I, Nagai S, Handa T, Muro S, et. al.
  • Journal Title: Am J Respir Crit Care Med 172 Pages: 1378-1382
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma. (2005)
  • Author(s): Matsumoto H, Niimi A, Takemura M, Ueda T, Minakuchi M, Tabuena R, Chin K, Mio T, Ito Y, Muro S, et. al.
  • Journal Title: Thorax 60 Pages: 277-281
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma (2005)
  • Author(s): Matsumoto, H., Niimi, A., Takemura, M., Ueda, T., Minakuchi, M., Tabuena, R., Chin, K., Mio, T., Ito, Y., Muro, S., Hirai, T., Morita, S., Fukuhara, S., Mishima, M
  • Journal Title: CERNED,YEAR Thorax 60 Pages: 277-281
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema (2005)
  • Author(s): Ito, I., Nagai, S., Handa, T., Muro, S., Hirai, T., Tsukino, M., Mishima, M
  • Journal Title: Am J Respir Crit Care Med 172 Pages: 1378-1382
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Impact of gastro-oesophageal reflux disease symptoms on chronic obstructive pulmonary disease exacerbation
  • Author(s): Terada K, Muro S, et. al.
  • Journal Title: Thorax (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Impact of gastro-oesophageal reflux disease symptoms on chronic obstructive pulmonary disease exacerbation
  • Author(s): Terada, K., Muro, S., Sato, S., Ohara, T., Haruna, A., Marumo, S, Kinose, D., Ogawa, E., Hoshino, Y., Niimi, A., Terada, T., Mishima, M
  • Journal Title: Thorax (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Arterial Hypoxia Correlated with the Inflammatory Profile in Induced Sputum from COPD Patients (2007)
  • Author(s): A., Sato, S., Mum, S., Sato, M., Nishioka, Y., Hoshino, E., Ogawa, T., Hirai, H., Nakamura, J., Yodoi, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: SanFrancisco American
  • Year and Date: 20070500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Corticosteroid Suppressed LPS Induced NOD2 Gene Expression in Airway Epithelial Cells.(Kyoto, Japan) (2007)
  • Author(s): D., Kinose, E., Ogawa, M., Nishioka, Y., Hoshino, T., Hirai, S., Muro, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: SanFrancisco American
  • Year and Date: 20070500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Thioredoxin Suppressed Cigarette Smoke Induced Emphysema in Mice (2007)
  • Author(s): A., Sato, Y., Hoshino, M., Takenaka, S., Muro, H., Nakamura, J., Yodoi, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: SanFrancisco American
  • Year and Date: 20070500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COPDの胃食道逆流と消化性潰瘍 (2007)
  • Author(s): 室 繁郎
  • Organizer: 第17回日本呼吸ケア・リハビリテーション学会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Impacts of gastro-oesophageal reflux symptoms on exacerbations of COPD (2007)
  • Author(s): K. Terada, S. Muro, et. al.
  • Organizer: European Respiratory Society
  • Place of Presentation: Stockholm
  • Year and Date: 2007-09-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Corticosteroid Suppressed LPS Induced NOD2 Gene Expression in Airway Epithelial Cells (2007)
  • Author(s): D. Kinose, M. D., E. Ogawa, M. D., Ph, M. Nishioka, M. D., Y. Hoshino, M. D., Ph, T. Hirai, M. D., Ph, S. Muro, M. D., Ph, M. Mishima, M. D.,
  • Organizer: American Thoracic Society
  • Place of Presentation: SanFrancisco
  • Year and Date: 2007-05-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Thioredoxin Suppressed Cigarette Smoke Induced Emphysema in Mice, (2007)
  • Author(s): A. Sato, M. D., Y. Hoshino, M. D., Ph, M. Takenaka, S. Muro, M. D., Ph, H. Nakamura, M. D., Ph, J. Yodoi, M. D., Ph, M. Mishima, M. D.
  • Organizer: American Thoracic Society
  • Place of Presentation: SanFrancisco
  • Year and Date: 2007-05-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Arterial Hypoxia Correlated with the Inflammatory Profile in Induced Sputum from COPD Patients, (2007)
  • Author(s): A. Sato, M. D., S. Muro, M. D., Ph, S. Sato, M. D., Ph, M. Nishioka, M. D., Y. Hoshino, M. D., Ph, E. Ogawa, M. D., Ph, T. Hirai, M. D., Ph, H. Nakamura, M. D., Ph, J. Yodoi, M. D., Ph, M. Mishima, M. D
  • Organizer: American Thoracic Society
  • Place of Presentation: SanFrancisco
  • Year and Date: 2007-05-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Thioredoxin Prevents Cigarette Smoke Induced Oxidative Stress and Apoptosis (2006)
  • Author(s): A., Sato, Y., Hoshino, H., Nakamura, M., Narita, S., Muro, M., Mishima, J., Yodoi
  • Organizer: Thoracic Society
  • Place of Presentation: SanDiego American
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of Connective Tissue Growth Factor Gene Expression by Lipopolysaccharide in Bronchial Epithelial Cells (2006)
  • Author(s): M., Nishioka, E., Ogawa, T., Hirai, S., Muro, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: SanDiego American
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Annual Changes in Computed Tomography Measurements and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease (2006)
  • Author(s): T., Ohara, T., Hirai, S., Sato, E., Ogawa, A. Sato, M., Nishioka, K., Terada, D., Kinose, S., Muro, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: SanDiego American
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Body Mass Index in Patients with Chronic Obstructive Pulmonary Disease ; Correlation with Low Attenuation Areas on Computed Tomography (2006)
  • Author(s): E., Ogawa, Y., Nakano, S., Muro, H., Sakai, T., Hirai, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: SanDiego American
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] チオレドキシンによる喫煙肺傷害の抑制効 (2006)
  • Author(s): 佐藤篤靖、星野勇馬、原富次郎、室繁郎、成田牧子、中村 肇、三嶋理晃、淀井淳司
  • Organizer: 第9回京都免疫ワークショップ学術集会プログラム「基礎及び臨床免疫学のクロストーク」
  • Place of Presentation: (京都)芝蘭会館(本館:稲盛ホール)
  • Year and Date: 2006-04-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Thioredoxin Ameliorates Cigarette Smoke-Induced Local and Systemic Inflammation in Mice (2005)
  • Author(s): A., Sato, Y., Hoshino, T., Ham, S., Muro, M., Narita, H., Nakamura, J., Yodoi, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: SanDiego American
  • Year and Date: 20050500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Time Course of Airway Resistance after Inhaled Bronchodilator in the Patients with COPD (2005)
  • Author(s): S., Sato, T., Hirai, S., Muro, T., Ohara, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: SanDiego American
  • Year and Date: 20050500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Airway Wall Thickening Assessed by CT Correlates with the Responsiveness to Bronchodilators in COPD Patient (2005)
  • Author(s): S., Mum, S., Sato, Y,. Nishioka, T., Ohara, A., Sato, E., Ogawa, T., Hirai, T., Hajiro, M., Mishima, D., H., Horstman, S., R., Snapper, Y., Nakano
  • Organizer: Thoracic Society
  • Place of Presentation: SanDiego American
  • Year and Date: 20050500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 肺障害に対するレドックス制御による治療有効性の検討喫煙モデルマウスを用いて (2005)
  • Author(s): 佐藤篤靖、星野勇馬、原富次郎、成田牧子、室繁郎, 他
  • Organizer: 第8回伊豆レスピロロジーフォーラム
  • Place of Presentation: 伊豆
  • Year and Date: 2005-08-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 慢性閉塞性肺疾患患者の呼吸器外科手術 呼吸器内科との協同アプローチ (2005)
  • Author(s): 室 繁郎
  • Organizer: 第22回日本呼吸器外科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2005-06-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 慢性閉塞性肺疾患患者に於ける気道病変・気腫化病変の程度と気道可逆性との関連. (2005)
  • Author(s): 室 繁郎, 佐藤 晋, 西岡慶善, 大原 直, 佐藤篤靖, 他
  • Organizer: 日本内科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2005-04-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Morphological Study of Emphysematous Lesion in Klotho Mice Using Fractal Analysis (2004)
  • Author(s): A., Sato, T., Hirai, S., Muro, N., Kita, A., Imura, Y., Nabeshima, M., Mishima
  • Organizer: Thoracic Society
  • Place of Presentation: Seattle American
  • Year and Date: 2004-05-26
  • Description: 「研究成果報告書概要(欧文)」より