2006 Fiscal Year Final Research Report Summary
Exhaustive analysis about juvenile idiopathic arthritis by using an anti-IL-6 receptor antibody
| Project/Area Number |
16390305
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yokohama City University |
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Principal Investigator |
YOKOTA Shumpei Yokohama City University, Medical Research, Professor, 医学研究科, 教授 (10158363)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masaaki Yokohama City University, Medical Department, Associate professor, 医学部, 準教授 (30254204)
MITSUDA Toshihiro Yokohama City University, Medical Hospital, Associate professor, 付属病院, 準教授 (20336548)
NARUTO Takuya Yokohama City University, Medical Department, Researcher, 医学部, 研究員 (60438124)
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| Project Period (FY) |
2004 – 2006
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| Keywords | juvenile idiopathic arthritis / IL-6 / anti IL-6 receptor antibody / investigation for pathogenesis / hypercytokine diseases |
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| Research Abstract |
We analyzed the identification of the target molecule of the IL-6 obstruction treatment by using proteomics method such as 2D-DIGE (fluorescent labeling 2 dimension differential gel electrophoresis) and iTRAQ (Isotope Tag for Relative and Absolute Quantitation) method. Additionally, we examined the role of IL-6 on Kawasaki disease or CINCA syndrome as an axis of this research.
Furthermore, we would like to analyze the IL-6 diseases (cytokine-related disease) in pediatric field, and to examine the structure and/or the function of the obstruction target molecule of antiIL-6 receptor antibody treatment front and back in detail in future. Finally, in this study, we detected lots of proteins in sera and plasma of JIA patients using two methods, 2D-DIGE and iTRAQ and could identify some of them.
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