2007 Fiscal Year Final Research Report Summary
Analysis of mitochondria-nucleus inter-genetic network
| Project/Area Number |
16390308
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
KOGA Yasutoshi Kurume University, medical department, professor (00225400)
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| Co-Investigator(Kenkyū-buntansha) |
AKITA Yukihiro KURUME UNIVERSITY, medical department, assistant (20330821)
HIRATA Koji Saga junior college, life environmental department, associate professor (50360293)
MAJIMA Hideyuki Kagoshima University, graduate school of medical and dental sciences, 教授 (60165701)
NISHIOKA Jyunko KURUME UNIVERSITY, medical department, assistant (00449919)
YATSUGA Shuichi KURUME UNIVERSITY, medical department, assistant (10454919)
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| Project Period (FY) |
2004 – 2007
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| Keywords | mitochondrial myopathy / nuclear gene / mitohondrial gene / point mutation / respiratory chain enzyme defect / MELAS / ragged red fiber / energy crisis |
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| Research Abstract |
Our specific aim of this study is to clarify the mitochondria-nucleus inter-genetic network system. To enable for this purpose, we established the rho zero cybrid system in which cell has various percentage of an A3243G mutation in the mitochondrial tRNALeu(UUR) gene. Using cybrids which has 100% wild type and 100% mutant, we isolated the RNA and analyzed microarray in order to identify the specific gene, a candidate of controlling gene of mitochondria-nucleus interaction. One gene was identified as minitin which was recognized as a cancer suppressing gene and expressed mainly in esophagus cancer, is a candidate for one of the unidentified nuclear subunits of mitochondrial respiratory complex I gene. Another project is the Klotho gene KO mouse, which is recognized as early senile and dementic model We have not been identified of new gene which contribute the mitochondria-nucleus inter-genetic network system.
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Research Products
(63 results)
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[Journal Article] A novel MYC-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma.2005
Author(s)
Tsuneoka M, Teye K, Arima N, Soejima M, Otera H, Ohashi K, Koga Y, Fujita H, Shirouzu K, Kimura H, Koda Y
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Journal Title
J Biol Chem. 280(20)
Pages: 19977-19985
Description
「研究成果報告書概要(欧文)」より
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[Presentation] MELAS and L-arginine therapy.2006
Author(s)
Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N.
Organizer
11th International Congress on Neur omuscular Diseases.
Place of Presentation
Istanbul, Turkey
Year and Date
20060703-07
Description
「研究成果報告書概要(欧文)」より
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[Presentation] MELAS and L-arginine therapy.2006
Author(s)
Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Katayama K, Matsuishi T.
Organizer
Workshop sponsored by the Research Grant(17A-10) for Nervous and Mental Disorders. The Front Line of Therapy for Mitochondrial Myopathy
Place of Presentation
Tokyo, Japan
Year and Date
2006-10-10
Description
「研究成果報告書概要(欧文)」より
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[Presentation] L-arginine therapy in MELAS.2005
Author(s)
Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Matsuishi T.
Organizer
18th World Congress of Neurology.
Place of Presentation
Sydney, Australia
Year and Date
20051105-11
Description
「研究成果報告書概要(欧文)」より
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[Presentation] MELAS and -arginine Therapy.2004
Author(s)
Koga Y, Akita Y, Nishioka J, Povalko N, Matsuishi T.
Organizer
6th European Meeting on Mitochondrial Pathology.
Place of Presentation
Nijmegen, Holland
Year and Date
20040630-0704
Description
「研究成果報告書概要(欧文)」より
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