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2005 Fiscal Year Final Research Report Summary

Role of XBP1 in neurons

Research Project

Project/Area Number 16390328
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionRIKEN

Principal Investigator

KATO Tadafumi  RIKEN, Aging and Psychiatric Research Group, Group Director, 老化・精神疾患研究グループ, グループディレクター (30214381)

Project Period (FY) 2004 – 2005
Keywordsbipolar disorder / endoplasmic reticulum stress / XBP1 / neurons
Research Abstract

High concordance rate of bipolar disorder in monozygotic (MZ) twins (approximately 70%) suggests the role of genetic factors in this disorder. We performed DNA microarray analysis in the lymphoblastoid cell lines obtained from two pairs of MZ twins discordant for bipolar disorder. We found that two genes, XBP1 and GRP78 (HSPA5), both of which have a pivotal role in endoplasmic reticulum (ER) stress signaling, were commonly down-regulated. XBP1 is located at 22q12, the common linkage locus for bipolar disorder and schizophrenia. GRP78 is regulated by XBP1, and induced by valproate. Thus, we further analyzed the roles of XBP1 and GRP78 in the pathophysiology of bipolar disorder. Response of XBP 1 and GRP78 to ER stress was smaller in patients with bipolar disorder compared with controls. We found a functional polymorphism in the promoter of XBP1, named -116C/G. The functional disturbance caused by -116G was improved by valproate. We found that XBP1 is located throughout the neuron and transport the neuroplastic signals from dendrite to the nucleus. By DNA microarray analysis, XBP1 was found to regulate WFS 1. These findings suggest that XBP1 plays a role in neuroplastic changes and XBP1-WFS1 pathway plays a role in mental disorders.

  • Research Products

    (30 results)

All 2006 2005 2004

All Journal Article (30 results)

  • [Journal Article] XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells2006

    • Author(s)
      Kakiuchi C, Ishiwata M, Hayashi A, Kato T
    • Journal Title

      Journal of Neurochemistry 97・2

      Pages: 545-555

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells.2006

    • Author(s)
      Kakiuchi C, Ishiwata M, Hayashi A, Kato T.
    • Journal Title

      Journal of Neurochemistry 97:2

      Pages: 545-555

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Rlationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI2005

    • Author(s)
      Kusumi I, Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugu H, Kato T, Koyama T
    • Journal Title

      Neuroscience Letters 391

      Pages: 7-10

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] XBP1 gene polymorphism (-116C/G) and personality2005

    • Author(s)
      Kato C, Kakiuchi C, Umekage T, Tochigi M, Kato N, Kato T, Sasaki T
    • Journal Title

      American Journal of Medical Genetics, Part B 136B

      Pages: 103-105

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Lithium response and -116C/G polymorphism of XBP1 in Japanese patients with bipolar disorder2005

    • Author(s)
      Kakiuchi C, Kato T
    • Journal Title

      International Jounal of Neuropsychopharmacology 8

      Pages: 631-632

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Functional polymorphisms of HSPA5 : Possible association with bipolar disorder2005

    • Author(s)
      Kakiuchi C, e al.
    • Journal Title

      Biochemical and Biophysical Research Communications 336

      Pages: 1136-1143

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 躁うつ病(双極性障害)における小胞体ストレスの異議2005

    • Author(s)
      加藤忠史, 垣内千尋, 林朗子, 笠原和起
    • Journal Title

      実験医学 23・18

      Pages: 2795-2798

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 双極性障害のエンドフェノタイプ2005

    • Author(s)
      加藤忠史
    • Journal Title

      分子精神医学 5・2

      Pages: 145-151

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 神経細胞におけるmRNA局在化とその機能的意義2005

    • Author(s)
      加藤忠史
    • Journal Title

      精神科 6・4

      Pages: 385-388

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 双極性障害の病因仮設とそれに基づく新しい治療2005

    • Author(s)
      加藤忠史
    • Journal Title

      臨床精神薬理 8・3

      Pages: 289-296

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI.2005

    • Author(s)
      Kusumi I, Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama T.
    • Journal Title

      Neuroscience Letters 391

      Pages: 7-10

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] XBP1 gene polymorphism (-116C/G) and personality.2005

    • Author(s)
      Kato C, Kakiuchi C, Umekage T, Tochigi M, Kato N, Kato T, Sasaki T.
    • Journal Title

      American Journal of Medical Genetics, Part B 136B

      Pages: 103-105

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Lithium response and -116C/G polymorphism of XBP1 in Japanese patients with bipolar disorder.2005

    • Author(s)
      Kakiuchi C, Kato T.
    • Journal Title

      International Journal of Neuropsychopharmacology 8

      Pages: 631-632

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Functional polymorphisms of HSPA5 : Possible association with bipolar disorder.2005

    • Author(s)
      Kakiuchi C, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 336

      Pages: 1136-1143

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of ER stress in bipolar disorder.2005

    • Author(s)
      Kato T, Kakiuchi C, Hayashi A, Kasahara T.
    • Journal Title

      Experimental Medicine 23:18

      Pages: 2795-2798

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Endophenotypes of bipolar disorder.2005

    • Author(s)
      Kato T.
    • Journal Title

      Japanese Journal of Molecular Psychiatry 5:2

      Pages: 145-151

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Functional significance of mRNA localization in neurons.2005

    • Author(s)
      Kato T.
    • Journal Title

      Psychiatry 6:4

      Pages: 385-388

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Pathophysiological hypotheses and new treatment of bipolar disorder.2005

    • Author(s)
      Kato T.
    • Journal Title

      Japanese Journal of Clinical Psychopharmacology 8:3

      Pages: 289-296

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population2004

    • Author(s)
      Kakiuchi C, Ishiwata M, Umekage T, Tochigi M, Kohda K, Sasaki T, Kato T
    • Journal Title

      Psychiatry and Clinical Neurosciences 58

      Pages: 438-440

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 一卵性双生児不一致例による病因遺伝子同定2004

    • Author(s)
      加藤忠史
    • Journal Title

      生体の科学 50・5

      Pages: 546-547

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 双極性障害と小胞体ストレス応答関連遺伝子2004

    • Author(s)
      垣内千尋, 加藤忠史
    • Journal Title

      医学のあゆみ 211・3

      Pages: 258

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 小胞体ストレス反応の異常と躁うつ病2004

    • Author(s)
      加藤忠史, 垣内千尋
    • Journal Title

      蛋白質・核酸・酵素 49・7

      Pages: 133-1134

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 双極性障害の分子遺伝学的メカニズム2004

    • Author(s)
      垣内千尋, 加藤忠史
    • Journal Title

      精神科 4・5

      Pages: 287-291

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 一卵性双生児躁うつ病不一致例におけるDNAマイクロアレイ解析2004

    • Author(s)
      加藤忠史, 垣内千尋
    • Journal Title

      細胞工学 23・4

      Pages: 429-432

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population.2004

    • Author(s)
      Kakiuchi C, Ishiwata M, Umekage T, Tochigi M, Kohda K, Sasaki T, Kato T.
    • Journal Title

      Psychiatry and Clinical Neurosciences 58

      Pages: 438-440

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Identification of causative genes from discordant twins.2004

    • Author(s)
      Kato T.
    • Journal Title

      Seitai-no-Kagaku 50:5

      Pages: 546-547

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bipolar disorder and endoplasmic reticulum stress response-related genes.2004

    • Author(s)
      Kakiuchi C, Kato T.
    • Journal Title

      Journal of Clinical and Experimental Medicine 211:3

      Pages: 258

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dysfunction of endoplasmic reticulum stress response and bipolar disorder.2004

    • Author(s)
      Kato T, Kakiuchi C.
    • Journal Title

      Protein, Nucleic Acid and Enzyme 49:7

      Pages: 1133-1134

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular genetic mechanisms of bipolar disorder.2004

    • Author(s)
      Kakiuchi C, Kato T.
    • Journal Title

      Psychiatry 4:5

      Pages: 287-291

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] DNA microarray analysis in monozygotic twins discordant for bipolar disorder.2004

    • Author(s)
      Kato T, Kakiuchi C.
    • Journal Title

      Cell Technology 23:4

      Pages: 429-432

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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