| Co-Investigator(Kenkyū-buntansha) |
SATO Akihiro Tohoku University, Graduate School of Medicine, Lecture, 大学院医学系研究科, 講師 (20250756)
MATSUHASHI Toshio Tohoku University, Hospital, Research Associate, 病院・助手 (40333819)
HISHINUMA Takanori Tohoku University, Hospital, Associate Professor, 病院・助教授 (20199003)
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| Research Abstract |
The IVR treatment of low invasiveness, especially endovascular treatment are spreading by clinical widely by the carotid artery stent, a coronary artery stent therapy,' etc. However, the key of the success or failure of this treatment is restenosis prevention after stent placement. Drugs elution stent, such as an immunosuppressant and an anti-cancer drug, is developed focusing on a European and American maker, and reduction of the rate of restenosis is reported. The stent development which had a cheap and new mechanism with it considered pressing need By precedence research, we already developed the self-extending Nitinol stent aimed at obtaining a biliary tract cancer (Sendai Stent), and also acquire drug-regulatory-affairs recognition. Moreover, it acted to the covering technology which Nakayama which was a co-investigator (2004-2005) developed as coaptation, and the self-extending covered stent is succeeded in the trial production. The stent which we are developing tends to make man
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y small holes in the covering stent, is making the stent lumen cover with self endothelial cells, tends to make the anti-thrombus therapy after detention unnecessary, and tends to prevent the restenosis of the stent lumen. Biological usefulness and safety were checked with improvement of the covered stent using adult dogs during the research. The new covering stent could be developed and the society and the report announced the result (Sato S, Nakayama Y, Ishibashi T. J Biomed Mater Res B Appl Biomater.2007) (T.Ishibashi, A.Sato, T.Matsuhashi, T.Yamada, K.Takase, S.Sato, Y.Nakayama A new design for a self-expanding, nitinol, microporous, covered stent. An experimental study ) The problem which some should improve from animal experiment data was found. For example, although incurvation peculiar to SENDAISTENT and the lumen retention at the time of meandering were good at the time of un-covering, lumen holding power deteriorated at the time of covering. Thickness of the velamen of an artificial blood vessel was made thin as this improving point, and elastic power and extended power have been improved. Although there is also a not yet solvable problem, it has been the biggest future subject. Less
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