Development of small diameter artificial blood vessel for remodeling of elastomeric-artery

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 16390359
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Mie University
• Principal Investigator: MIYAMOTO Keiichi Mie University, Graduate School of Engineering, Associate Professor, 大学院工学研究科, 助教授 (70252343)
• Co-Investigator(Kenkyū-buntansha): HIRATA Hitoshi Nagoya University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (80173243) ; SHIMONO Takatsugu Mie University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 (80206242) ; HORIUCHI Takashi Mie University, Graduate School of Engineering, Professor, 大学院工学研究科, 教授 (10201758)
• Project Period (FY): 2004 – 2006
• Keywords: Elastin / Cell / Artificial vein / Extra cellular matrix / Differentiation / Dynamic cell culture / Smooth mescal cell

Research Abstract

The aims of this study are the development of a novel small diameter artificial blood vessel using elastin matrix for treatment of vessel disease. In 2004 (first year), the cell cultured dish and elastic-sheet for the dynamic cell culture were prepared. And in 2005 (second year), the adhesion properties was researched as the reactions of blood wall-cells for these materials. In 2006 (final year), the differentiation property of smooth muscle cells on the elastin-matrix was researched.
The smooth muscle cells, endocrinal cells and fibroblast cells were evaluated on the elastic-sheets, in results, the important information was taken as the acceleration of differentiation of smooth muscle cells and the inhibition of proliferation by elastin materials. In this study, we concluded that elastin matrix was the suitable material for remodeling of elastomeric-artery under dynamic cell culture conditions.