2006 Fiscal Year Final Research Report Summary
Development of a novel molecular targeting therapy against VEGF for brain edema
| Project/Area Number |
16390410
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
KOHMURA Eiji KobeUniversity, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (30225388)
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| Co-Investigator(Kenkyū-buntansha) |
近藤 威 神戸大学, 医学部附属病院, 講師 (50273769)
三宅 茂 神戸大学, 医学部附属病院, 助手 (30362784)
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| Project Period (FY) |
2004 – 2006
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| Keywords | brain edema / VEGF / cold injury / ischemia |
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| Research Abstract |
In the rat cold injury model, the VEGF receptor antagonist VGA1155 significantly reduced the brain water content and the maximum effect was obtained when given at 30 minutes after injury. This effect was in dose-dependent manner and the dose of 25 mg/kg showed the maximum effect. With this dose, VGA1155 also significantly reduced vascular permeability. Histological evaluation of brain lesion showed no significant reduction of damaged area 1 week after injury by VGA1155. The data suggest that VGA1155 may have antiedematous effect in acute phase after cold injury.
In the rat middle cerebral artery transient occlusion model, induced by the suture occlusion method for 2 hours, the brain water content at 24 hours after cerebral ischemia was significantly reduced by intraperitoneal administration of VGA1155 and the dose of 10 mg/kg showed the maximum effect on brain water content. With this dose, VGA1155 also reduced vascular permeability at 4 hours after the reperfusion by intravenous injection of Evans blue. Furthermore, VGA1155 administration significantly reduced infarct volume and improved neurological scores at 1 week after ischemic injury. The data suggested that VGA1155 may have antiedematous effect in acute phase after transient focal cerebral ischemia.
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