2007 Fiscal Year Final Research Report Summary
Development of Tumor-Specific Immunotherapy for Bone and Soft-Tissue Sarcomas
| Project/Area Number |
16390439
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | 独立行政法人国立病院機構(大阪医療センター臨床研究部) (2006-2007)
Osaka University (2004-2005) |
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Principal Investigator |
UEDA Takafumi 独立行政法人国立病院機構(大阪医療センター臨床研究部), Institute for Clinical Research, Osaka National Hospita, M.D. (00324773)
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| Co-Investigator(Kenkyū-buntansha) |
MYOUI Akira Osaka University Hospital, Medical Center for Translational Research, Associate Professor (10263261)
YOSHIKAWA Hideki Osaka University Graduate School of Medicine, Department of Orthopaedics, Professor/Chairman (60191558)
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| Project Period (FY) |
2004 – 2007
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| Keywords | malignant bone & soft-tissue tumor / sarcomas / tumor-specific immnotherapy / WT1 gene / SSX gene / DC vaccine therapy |
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| Research Abstract |
To develop tumor-specific immunotherapy for bone and soft-tissue sarcomas, we have planned and conducted translational and clinical researches as follows ; 1) We analyzed the overexpression of WT1 gene and its correlation with prognosis in 52 patients with soft-tissue sarcoma, elucidating WT1 overexpression being as a prognostic factor for patiets with soft-tissue sarcoma and WT1 peptide to be a candidate of molecular targets for tumor-specific immunotherapy for sarcomas(Cancer 106(10) : 2233-2240, 2006) . 2) We have started a phase I/II clinical trial of tumor-specific immunotherapy using WT1 peptide for a variety of solid cansers including bone and soft-tissue sarcomas(30 cases) from April 2004, to evaluate the efficacy and toxicity of WT1 peptide. Twenty cases of locally advanced and/or metastatic bone and soft-tissue sarcomas were enrolled to the trial until March 2008. There are 8 SD(stable disease) , 11PD(progressive disease) , and one suspended case by patient's decision, without PR(partial response) /or CR(complete response) cases. We have not yet experienced severe toxicity in WT1 vaccinations except for local redness/swelling of intracutaneous injection sites. 3) We have performed an experimental DC(denritic cell) immunotherapy using C3H murine model of lung metastases from osteosarcoma(LM8) , which was originally established in our laboratory, and demonstrated the anti-tumor activity of DC vaccine immunotherapy for primary tumors and lung metastases of LM8 osteosarcoma cells(Clin Orthop 453 : 318-327, 2006).
For further projects, we will progress the phase I/II clinical trial of tumor-specific immunotherapy using WT1 peptide for bone and soft-tissue sarcomas(30 cases) , and also develop a new molecular targeting therapy for bone and soft-tissue sarcomas focusing SSX gene products as a cancer-testis antigen frequently expressed not only in sarcomas but also in a variety of solid cancers.
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[Journal Article] Ossifying fibroma vs fibrous dysplasia of the jaw : molecular and immunological characterization.2007
Author(s)
Toyosawa S, Yuki M, Kishino M, Ogawa Y, Ueda T, Murakami S, Konishi E, Iida S, Kogo M, Komori T, Tomita Y
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Journal Title
Modern Pathol 20(3)
Pages: 389-396
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prognostic significance of CD100 expression in soft tissue sarcoma.2007
Author(s)
Ch'ng E, Tomita Y, Zhang B, He J, Hoshida Y, Qiu Y, Morii E, Nakamichi I, Hamada K, Ueda T, Aozasa K
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Journal Title
Cancer 110(1)
Pages: 164-172
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] False positive(18) F-FDG PET in an ischial chondroblastoma ; an analysis of glucose transporter 1 and hexokinase II expression.2006
Author(s)
Hamada, K., Ueda, T., Tomita, Y., Higuchi, I., Inoue, A., Tamai, N., Myoui, A., Aozasa, K., Yoshikawa, H., Hatazawa, J.
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Journal Title
Skeletal Radiol 35(5)
Pages: 306-310
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Long-term follow-up after limb salvage in skeletally immature children with a primary malignant tumor of the distal end of the femur.2006
Author(s)
Futani, H., Minamizaki, T., Nishimoto, Y., Abe, S., Yabe, H., Ueda, T.
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Journal Title
J Bone Joint Surg[A] 88(3)
Pages: 595-603
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prognostic significance of activated AKT expression in soft-tissue sarcoma.2006
Author(s)
Tomita, Y., Morooka, T., Hoshida, Y., Zhang B, Qiu, Y., Nakamichi, I., Hamada, K., Ueda, T., Naka, N., Kudawara, I., Aozasa, K.
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Journal Title
Clin Cancer Res 12(10)
Pages: 3070-3077
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prognostic significance of Wilms tumor gene(WT1) mRNA expression in soft tissue sarcoma.2006
Author(s)
Sotobori, T., Ueda, T., Oji, Y., Naka, N., Araki, N., Myoui, A., Sugiyama, H., Yoshikawa, H.
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Journal Title
Cancer 106(10)
Pages: 2233-2240
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A phase I/II trial of a WT1(Wilms' tumor gene) peptide vaccine in patients with solid malignancy : Safety assessment based on the phase I data.2006
Author(s)
Morita S, Oka Y, Tsuboi A, Kawakami M, Maruno M, Izumoto S, Osaki T, Taguchi T, Ueda T, Myoui A, Nishida S, Shirakata T, Ohno S, Oji Y, Aozasa K, Hatazawa J, Udaka K, Yoshikawa H, Yoshimine T, Noguchi S, Kawase I, Nakatsuka S, Sugiyama H, Sakamoto J
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Journal Title
Jpn J Clin Oncol 36(4)
Pages: 231-236
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Reassessment of the 1993 Osaka grading system for localized soft tissue sarcoma in Japan.2006
Author(s)
Tomita Y, Morooka T, Hoshida Y, Zhang B, Qiu Y, Nakamichi I, Hamada K, Ueda T, Naka N, Kudawara I, Aozasa K
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Journal Title
Anticancer Res 26(6C)
Pages: 4665-4669
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Preliminary results of phase I trial of oral uracil/tegafur(UFT) , leucovorin plus irinotecan and radiation therapy for patients with locally recurrent rectal cancer.2006
Author(s)
Yasui M, Ikeda M, Sekimoto M, Yamamoto H, Takemasa I, Ueda T, Shimizu J, Fukunaga M, Suzuki O, Inoue T, Monden M
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Journal Title
World J Surg Oncol 4 83
Pages: 1-7
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Peripheral nerve schwannoma : Two cases exhibiting increased FDG uptake in early and delayed PET imaging.2005
Author(s)
Hamada, K., Ueda T., Higuchi, I., Inoue, A., Tamai, N., Myoui, A., Tomita, Y., Aozasa, K., Yoshikawa, H., Hatazawa, J.
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Journal Title
Skeletal Radiol 34
Pages: 52-57
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Quantification of SSX mRNA expression in human bone and soft tissue tumors using nucleic acid sequence-based amplification.2005
Author(s)
Naka, N., Joyama, S., Tsukamoto, Y., Yoshioka, K., Hashimoto, N., Ujiiye, T., Hayashi, T., Kawase, M., Mano, M., Ishiguro, S., Myoui, A., Ueda, T., Yoshikawa, H., Araki, N., Itoh, K.
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Journal Title
J Mol Diagn 7
Pages: 187-197
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Extraskeletal mesenchymal chondrosarcoma : An imaging review of ten new patients.2005
Author(s)
Hashimoto, N., Ueda, T., Joyama, S., Araki, N., Beppu, Y., Tatezaki, S., Matsumoto, S., Nakanishi, K., Tomita, Y., Yoshikawa, H.
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Journal Title
Skeletal Radiol 34(12)
Pages: 785-792
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] FDG-PET imaging for chronic expanding hematoma in pelvis with massive bone destruction.2005
Author(s)
Hamada, K., Myoui, A., Ueda, T., Higuchi, I., Inoue, A., Tamai, N., Yoshikawa, H., Hatazawa, J.
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Journal Title
Skeletal Radiol 34(12)
Pages: 807-811
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Myxoid liposarcoma with adipocytic maturation : Detection of TLS/CHOP fusion gene transcript.2004
Author(s)
Nakanishi, H., Araki, N., Joyama, S., Higuchi, C., Mano, M., Ishiguro, S., Itoh, K., Ueda, T., Yoshikawa, H.
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Journal Title
Diagn Mol Pathol 13(2)
Pages: 92-96
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Interleukin-6/ soluble interleukin-6 receptor signaling attenuates proliferation and invasion, and induces morphological changes of a newly established pleomorphic malignant fibrous histiocytoma cell line.2004
Author(s)
Nakanishi, H., Yoshioka, K., Joyama, S., Araki, N., Myoui, A., Ishiguro, S., Ueda, T., Yoshikawa, H., Itoh, K.
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Journal Title
Am J pathol 165(2)
Pages: 471-480
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia.2004
Author(s)
Toyosawa, S., Tomita, Y., Kishino, M., Hashimoto, J., Ueda, T., Tsujimura, T., Aozasa, K., Ijuhin, N., Komori, T.
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Journal Title
Modern Pathol 17(5)
Pages: 573-578
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Postradiation soft tissue sarcoma : A multiinstitutional analysis of 14 cases in Japan.2004
Author(s)
Fang, Z., Matsumoto, S., Ae, K., Kawaguchi, N., Yoshikawa, H., Ueda, T., Ishii, T., Araki, N., Kito, M.
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Journal Title
J Orthop Sci 9(3)
Pages: 242-246
Description
「研究成果報告書概要(欧文)」より
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