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2006 Fiscal Year Final Research Report Summary

Efficacy of therapy for osteoporosis on oral health

Research Project

Project/Area Number 16390616
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionAichi-Gakuin Unviersity

Principal Investigator

INAGAKI Koji  Aichi-Gakuin Unviersity, Dept of Periodontology, Sch of Dent, Associate Professor, 歯学部, 助教授 (50211058)

Co-Investigator(Kenkyū-buntansha) MIKI Takami  Osaka City University, Graduate School of Medicine, Geriatric Medicine, Professor, 医学部, 教授 (90174002)
TAGUCHI Akira  Hiroshima University, Department of Oral and Maxillofacial Radiology, Associate Professor, 医学部・歯学部附属病院, 助教授 (70243582)
ISHIHARA Yuichi  Aichi-Gakuin Unviersity, Dept of Periodontology, Assistant Professor, 歯学部, 講師 (50261011)
Project Period (FY) 2004 – 2006
Keywordsosteoporosis / bone mineral density / periodontal disease / community periodontal index / fractal dimension / bisphosphonate
Research Abstract

The purpose of the present study was to determine the relationship between periodontal status and panoramic radiographic measures (cortical shape and fractal dimension of the mandible) in postmenopausal women with osteoporosis, and compare the periodontal status of them who use bisphosphonate therapy with those who do not.
The population studied, which was part of a prospective bisphosphonate interventional study, consisted of 109 postmenopausal patients with osteoporosis (mean±SD, 67.8±6.3 years). Periodontal assessments at baseline included present teeth, alveolar bone loss (ABL) and community periodontal index (CPI). Mandibular cortical shape was categorized into one of three groups (normal, mildly to moderately eroded or severely eroded) on panoramic radiographs. Fractal dimension (FD) was also measured at periapical sites between canine and premolar of the mandible. Bone mineral density (BMD) of the lumbar spine was assessed by dual energy X-ray absorptiometry. Periodontal parameters between 33 women who use bisphosphonate therapy and 31 women who do not were compared.
The mean spine BMD was 0.656±0.075g/cm^2(64.9±7.4% of young adult mean). The mean number of teeth present, mean ABL and FD value were 20.2±8.1, 25.7±9.8% and 1.589±0.034, respectively. The number of subjects with periodontitis (CPI codes 3 or 4), severe attachment loss (AL codes 2, 3 or 4) and eroded mandibular inferior cortex were 103(98.1 %), 67(63.8%) and 97(89.0%). The bisphosphonate therapy inhibited the percentage of teeth with CPI code 3 or 4(P < 0.01) and increased FD value (P < 0.10).
These results indicate that postmenopausal osteoporosis may be associated with eroded mandibular cortex and generalized advanced periodontal destruction. Osteoporotic women using bisphosphonate therapy show significantly lower probing depths and greater FD. These observations suggest that bisphosphonate therapy in osteoporotic women may play a beneficial role in periodontal status.

  • Research Products

    (14 results)

All 2007 2006

All Journal Article (14 results)

  • [Journal Article] Interaction of obesity and skeletal bone mineral density on tooth retention in Japanese postmenonausal women2007

    • Author(s)
      Ishii K, Taguchi A, Nakamoto T, 8 others
    • Journal Title

      Dentomaxillofac Radiol 36(1)

      Pages: 28-33

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Interaction of obesity and skeletal bone mineral density on tooth retention in Jananese nostmenonausal women2007

    • Author(s)
      Taguchi A, Tsuda M, Ohtsuka M, Inagaki K, 7 others
    • Journal Title

      Menopause 14(4)

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosis.2007

    • Author(s)
      Ishii K, Taguchi A, Nakamoto T, Ohtsuka M, Sutthiprapaporn P, Tsuda M, Kodama I, Kudo Y, Sumida H, Suei Y, Tanimoto K.
    • Journal Title

      Dentomaxillofac Radiol. 36(1)

      Pages: 28-33

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Interaction of obesity and skeletal bone mineral density on tooth retention in Japanese postmenopausal women.2007

    • Author(s)
      Taguchi A, Tsuda M, Ohtsuka M, Nakamoto T, Inagaki K, Noguchi T, Kudo Y, Yoshizumi M, Higashi Y, Suei Y, Tanimoto K.
    • Journal Title

      Menopause 14(4)

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Use of dental panoramic radiographs in identifying younger postmenopausal women with osteoporosis2006

    • Author(s)
      Taguchi A, Tsuda M, Ohtsuka M, Inagaki K, 9 others
    • Journal Title

      Osteoporos Int 17(3)

      Pages: 387-394

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 糖尿病教育入院患者の歯周病罹患状態と糖尿病合併症との関係2006

    • Author(s)
      坂野雅洋, 稲垣幸司, 真岡淳之, 小倉延重 他6名
    • Journal Title

      日歯周誌 48(3)

      Pages: 165-173

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Risk for vertebral osteoporosis in postmenopausal women with alterations of the mandible2006

    • Author(s)
      Taguchi A, Ohtsuka M, Inagaki K, 7 others
    • Journal Title

      Dentomaxillofac Radiol 17(3)

      Pages: 387-394

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Computer-aided system for measuring the mandibular cortical width on dental panoramic radiographs in identifying postmenopausal women with low bone mineral density2006

    • Author(s)
      Arifin AZ, Asano A, Taguchi A, 5 others
    • Journal Title

      Osteoporos Int 17(5)

      Pages: 753-759

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Diagnostic performance of general dental practitioners after lecture in identifying post-menopausal women with low bone mineral density by panoramic radiographs2006

    • Author(s)
      Sutthiprapaporn P, Taguchi A, Nakamoto T, 7 others
    • Journal Title

      Dentomaxillofac Radiol. 35(4)

      Pages: 249-252

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Use of dental panoramic radiographs in identifying younger postmenopausal women with osteoporosis2006

    • Author(s)
      Taguchi A, Tsuda M, Ohtsuka M, Kodama I, Sanada M, Nakamoto T, Inagaki K, Noguchi T, Kudo Y, Suei Y, Keiji Tanimoto K, Bollen AM, Hujoel PP.
    • Journal Title

      Osteoporos Int 17(3)

      Pages: 387-394

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The relationship of periodontal disease to diabetic complications in type 2 diabetes patients for education program2006

    • Author(s)
      Sakano M, Inagaki K, Sanaoka A, Ogura N, Noguchi T, Morita I, Nakagaki H, Fujimoto E, Adachi M, Taguchi A.
    • Journal Title

      J Jpn Soc Periodontol 48(3)

      Pages: 165-173

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Risk for vertebral osteoporosis in postmenopausal women with alterations of the mandible.2006

    • Author(s)
      Taguchi A, Ohtsuka M, Tsuda M, Nakamoto T, Kodama I, Inagaki K, Noguchi T, Kudo Y, Suei Y, Tanimoto K.
    • Journal Title

      Dentomaxillofac Radiol 17(3)

      Pages: 387-394

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Computer-aided system for measuring the mandibular cortical width on dental panoramic radiographs in identifying postmenopausal women with low bone mineral density.2006

    • Author(s)
      Arifin AZ, Asano A, Taguchi A, Nakamoto T, Ohtsuka M, Tsuda M, Kudo Y, Tanimoto K.
    • Journal Title

      Osteoporos Int. 17(5)

      Pages: 753-759

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Diagnostic performance of general dental practitioners after lecture in identifying post-menopausal women with low bone mineral density by panoramic radiographs.2006

    • Author(s)
      Sutthiprapaporn P, Taguchi A, Nakamoto T, Ohtsuka M, Mallick PC, Tsuda M, Kodama I, Kudo Y, Suei Y, Tanimoto K.
    • Journal Title

      Dentomaxillofac Radiol. 35(4)

      Pages: 249-252

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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