2006 Fiscal Year Final Research Report Summary
Exploration for Traditional Anti-infectious Medicinal Plants in Central Africa
| Project/Area Number |
16406003
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka university |
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Principal Investigator |
MURAKAMI Nobutoshi Osaka University, Graduate school of pharmaceutical sciences, Professor, 薬学研究科, 寄附講座教授 (00210013)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Koji Osaka University, Graduate school of pharmaceutical sciences, Assistant Professor, 薬学研究科, 寄附講座助助手 (50359840)
TAMURA Satoru Osaka University, Graduate school of pharmaceutical sciences, Assistant Professor, 薬学研究科, 寄附講座助手 (30362619)
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| Project Period (FY) |
2004 – 2006
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| Keywords | malaria / trypanosome / leishmania / parasitic infectious disease / Central Africa / traditional antiinfectious medicinal plants / biflavonoid / artemisinin |
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| Research Abstract |
Extensive exploration research for traditional anti-infectious medicinal plants in Central Africa disclosed twenty candidate medicinal plants. As a result of evaluation for in vitro antimalarial and trypanocidal activity of these collected medicinal plants, the MeOH extracts from Garcinia kola and Artemisia annua were shown to exhibit significantly potent antimalarial and trypanocidal activity, respectively.
Bioassay guided separation of the extracts resulted in isolation of three biflavonoids and artemisinin as responsible bioactive principles.
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