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2005 Fiscal Year Final Research Report Summary

Regulatory mechanism for spine actin-cytoskeleton underlying maintenance of efficacy of synaptic transmission

Research Project

Project/Area Number 16500209
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

FUKAZAWA Yugo  National Institute for Physiological Sciences, Cerebral Research, Assistant Professor, 大脳皮質機能研究系, 助手 (60343745)

Project Period (FY) 2004 – 2005
Keywordsactin cytoskeleton / sipen synapses / neuronal plasticity / long-term memory / electron microscopy
Research Abstract

The effects of glutamate on postsynaptic neurons are mediated by iGluRs in the dendritic plasma membrane. The iGluRs are accumulated at postsynaptic specializations, and a modification of synaptic efficacy by changing number and/or density of AMPA type iGluR at the postsynaptic specialization may be relevant to learning and memory. To study LTP-induced changes in distributions of AMPA and NMDA type iGluRs in the postsynaptic specialization of hippocampal neurons, we employed SDS-digested FRIL, with which 2-dimensional distribution of the membrane proteins can be analyzed quantitatively at &lt ; 20 nm resolution, and revealed that AMPA receptors, but not NMDA receptors, are abundant on the dendritic plasma membrane and AMPA receptors at the postsynaptic specialization on the dendritic spine, but not on the dendritic shaft, are regulated more dynamically than NMDA receptors after LTP induction.

  • Research Products

    (7 results)

All 2006 2005 2004

All Journal Article (7 results)

  • [Journal Article] Compartment-dependent co-localization of Kir3. 2-containing K^+ chnannels and GABA_B receptors in hippocampal pyramidal cells2006

    • Author(s)
      Kulik, Akos
    • Journal Title

      J. Neuroscience 26

      Pages: 4289-4297

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differential localization and regulation of stargazing-like protein, γ-8 and stargazing in the plasma membrane of hippocampal and cortical neurons2006

    • Author(s)
      Inamura, Mihoko
    • Journal Title

      Neuroscience research 55

      Pages: 45-53

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Compartment-dependent co-localization of Kir3.2-containing K^+ chnannels and GABA_B receptors in hippocampal pyramidal cells2006

    • Author(s)
      Kulik, Akos
    • Journal Title

      J.Neuroscience 26

      Pages: 4289-4297

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by Freeze-fracture replica labeling2005

    • Author(s)
      Hagiwara, Akari
    • Journal Title

      J. Comparative Neurology 489

      Pages: 195-216

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Two-dimensional neural activity mapping of the entire population of hippocampal CA1 pyramidal cells responding to fear conditioning2005

    • Author(s)
      Inoue, Koutarou
    • Journal Title

      Neuroscience research 51

      Pages: 417-425

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Two-dimensional neural activity mapping of th entire population of hippocampal CA1 pyramidal cells responding to fear conditioning2005

    • Author(s)
      Inoue, Koutarou
    • Journal Title

      Neuroscience research 51

      Pages: 417-425

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellum2004

    • Author(s)
      Kulik, Akos
    • Journal Title

      Eur J Neurosci 19

      Pages: 2169-2178

    • Description
      「研究成果報告書概要(和文)」より

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Published: 2007-12-13  

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