2005 Fiscal Year Final Research Report Summary
Molecular mechanisms underlying progenitor migration following methylmercury exposure in the developing brain
| Project/Area Number |
16500214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
KAKITA Akiyoshi Niigata University, Brain Research Institute, Associate Professor, 脳研究所, 助教授 (80281012)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Mineshi National Institute for Minamata Disease, Department of Epidemiology, Director, 疫学研究部, 調査室長 (60344420)
TAKAHASHI Hitoshi Niigata University, Brain Research Institute, Professor, 脳研究所, 教授 (90206839)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Progenitor migration / Brain development / methylmercury / Fetal Minamata disease / Molecular pathology / DNA chip |
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| Research Abstract |
To understand the effects of methylmercury (MeHg) on neuronal and glial progenitor migration in the developing cerebral cortex, we examined profile alterations in gene expression in the telencephalic mantle following fetal or neonatal administration of MeHg, wher an apparent disrupition of the progenitor migration had been elucidated histopathologically. We applied extracted mRNA samples to two kinds of DNA microarrays, which had been made under different biotechnological concepts. Then, we performed analysis of the plenty of data according to the bioinformatics methodologies. We selected 11 molecules, which could be regarded as candidates of specific molecular cues closely associated with the migration disturbance underlying MeHg neurotoxicity.
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