2005 Fiscal Year Final Research Report Summary
Functional analysis of Galanin-like peptide (GALP) in feeding regulation
| Project/Area Number |
16500228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Showa University |
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Principal Investigator |
GUAN Jian-Lian Showa Univ., Sch.of Med., Dept.of Anatomy, Assistant, 医学部, 助手 (20276538)
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| Co-Investigator(Kenkyū-buntansha) |
FUNAHASHI Hisayuki Showa Univ., Sch.of Med., Dept.of Anatomy, Associate Professor, 医学部, 助教授 (20317514)
ARATA Satoru Showa Univ., Centaer for Biotechnology, Assistant Professor, 組換えDNA実験室, 講師 (20159502)
SHIODA Seiji Showa Univ., Sch.of Med., Dept.of Anatomy, Professor, 医学部, 教授 (80102375)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Galanin-like peptide / GPCR / feeding regulation / hypothalamus |
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| Research Abstract |
The hypothalamus plays a critical role in regulation of feeding behavior, energy metabolism and reproduction. A novel peptide discovered in porcine hypothalamus has 60 amino acid peptide and a non-amidated C-terminus. Since a portion of this peptide is homology with galanin, it is named galanin-like peptide (GALP). GALP is mainly produced in the hypothalamic arcuate nucleus. GALP acts in the central nervous system, where it is involved in the regulation of feeding behavior. GALP-producing neurons make neuron networks with several feeding related peptide- producing neurons. Since GALP controls food intake and energy balance, it is possible that GALP is an important factor in development of obesity. Furthermore, we have succeeded to make transgenic (Tg) mice that express green fluorescence (EGFP) in GALP-containing neurons and also to make Tg mice that express EGFP in afferent GALP neurons in brain. As a result, it appeares that GALP-containing neurons make synaptic input from the piriform cortex and amygdala. Therefore, GALP may involve in feeding behavior, energy metabolism and reproduction, further studies on the morphology and function of GALP should continue to demonstrate further the understanding in brain function.
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[Journal Article] Morphological analysis of ghrelin and its receptor in the rat pancreas.2005
Author(s)
Kageyama H, Hirayama M, Funahashi H, Takenoya F, Kita T, Kato S, Sakurai J, Lee EY, Inoue S, Date Y, Nakazato M, Kangawa K, Shioda S.
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Journal Title
Regul Rept 126
Pages: 67-72
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Neuronal inputs to orexin neurons revealed by genetically encoded tracer in mice.2005
Author(s)
Sakurai T, Nagata R, Yamanaka A, Mukai Y, Tsujino N, Kageyama H, Kawamura H, Koyama Y, Kunita S, Takahashi S, Shioda S, Yanagisawa M.
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Description
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[Journal Article] Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca signaling in a reciprocal manner to leptin : orexigenic neuronal pathway in the mediobasal hypothalamus.2004
Author(s)
Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T.
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Journal Title
Eur J Neurosci 19
Pages: 1524-1534
Description
「研究成果報告書概要(欧文)」より
