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2006 Fiscal Year Final Research Report Summary

Mechanisms of sensory processing in the human cortex

Research Project

Project/Area Number 16500272
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

INUI Koji  National Institute for Physiological Sciences, Department of Integrative Physiology, Assistant professor, 総合生理研究系, 助教授 (70262996)

Project Period (FY) 2004 – 2006
KeywordsMEG / EEG / visual / auditory / tactile
Research Abstract

By using magnetoencephalography (MEG), we studied cortical mechanisms of sensory processing in humans on tactile (Inui et al. Cereb Cortex 2004), pain (Inui et al. Cereb Cortex 2006a), auditory (Inui et al. Cereb Cortex 2006b) and visual (Inui and Kakigi J Neurophysiol 2006; Inui et al. Neuroimage 2006) systems. Results showed several common features of processing among these sensory modalities. First, there are several parallel streams. For example, there are at least two streams in auditory processing running posterosuperiorly (from the primary auditory cortex to the belt region and then to the posterior region) and anteriorly (primary auditory cortex-belt-superior temporal gyrus). Second, the time delay between the two sequential activations is about 4 ms, for example, 3.6 ms between areas 3b and 1 and 4.4 ms between areas 1 and 5 for somatosensory processing. Third, early cortical activities exhibit reversals of polarity after 10 ms twice, resulting in a characteristic triphasic time course. Finally, later activities that follow several early activities do not show such a reversal of polarity and long lasting. For example, activities in the planum temporale (auditory), secondary somatosensory cortex (tactile and pain), or limbic structures (pain) belong to this type. Therefore, these activities should differ in function from early activities with the triphasic structure. We postulate that a basic role of early cortical activities is to receive inputs from the thalamus or convergent inputs from the thalamus and/or adjacent multiple cortical areas and to send their signals to the next point, while the later long-lasting activities are related to recognition of the stimuli. Early activities some 10 ms in duration or successive activations with a 4-5 ms time delay seem not appropriate for activities relating to recognition.

  • Research Products

    (10 results)

All 2006 2004 Other

All Journal Article (10 results)

  • [Journal Article] Timing of early activity in the visual cortex as revealed by simultaneous MEG and ERG recordings.2006

    • Author(s)
      Inui K, Sannan H, Miki K et al.
    • Journal Title

      Neuroimage 30

      Pages: 239-244

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Serial and parallel processing in the human auditory cortex : a magnetoencephalographic study.2006

    • Author(s)
      Inui K, Okamoto H, Miki K et al.
    • Journal Title

      Cerebral Cortex 16

      Pages: 18-30

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Temporal analysis of cortical mechanisms for pain relief by tactile stimuli in humans.2006

    • Author(s)
      Inui K, Tsuji T, Kakigi R
    • Journal Title

      Cerebral Cortex 16

      Pages: 355-365

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Temporal analysis of the flow from V1 to the extrastriate cortex in humans.2006

    • Author(s)
      Inui K, Kakigi R
    • Journal Title

      Journal of Neurophysiology 96

      Pages: 775-784

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Serial processing in the human somatosensory system.2004

    • Author(s)
      Inui K, Wang X, Tamura Y et al.
    • Journal Title

      Cerebral Cortex 14

      Pages: 851-857

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Serial processing in the human somatosensory system.

    • Author(s)
      Inui K et al.
    • Journal Title

      Cerebral Cortex 14

      Pages: 851-857

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Timing of early activity in the visual cortex as revealed by simultaneous MEG and ERG recordings.

    • Author(s)
      Inui K et al.
    • Journal Title

      Neuroimage 30

      Pages: 239-244

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Serial and parallel processing in the human auditory cortex : a magnetoencephalographic study.

    • Author(s)
      Inui K et al.
    • Journal Title

      Cerebral Cortex 16

      Pages: 18-30

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Temporal analysis of cortical mechanisms for pain relief by tactile stimuli in humans.

    • Author(s)
      Inui K et al.
    • Journal Title

      Cerebral Cortex 16

      Pages: 355-365

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Temporal analysis of the flow from V1 to the extrastriate cortex in humans.

    • Author(s)
      Inui K, Kakigi R.
    • Journal Title

      Journal of Neurophysiology 96

      Pages: 775-784

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2008-05-27  

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