• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

DEVELOPMENT OF A HIGHLY RESPONSIVE NEEDLE-TYPE GLUCOSE SENSOR USING POLYIMIDE FOR A WEARABLE ARTIFICIAL ENDOCRINE PANCREAS

Research Project

Project/Area Number 16500295
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

SAKAKIDA Michiharu  Kumamoto University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学薬学研究部, 助教授 (50170577)

Co-Investigator(Kenkyū-buntansha) ARAKI Eiichi  Kumamoto University, Graduate School of Medical Sciences, Professor, 大学院・医学薬学研究部, 教授 (10253733)
MIYAMURA Nobuhiro  Kumamoto University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学薬学研究部, 講師 (40274716)
TOYONAGA Tetsushi  Kumamoto University, Graduate School of Medical Sciences, Research Associate, 大学院・医学薬学研究部, 助手 (60295128)
Project Period (FY) 2004 – 2005
Keywordsneedle-type glucose sensor / artificial endocrine pancreas / insulin infusion pump / strict glucose regulation
Research Abstract

An ultimate goal of the development of an artificial endocrine pancreas is to achieve long-term strict glucose regulation in diabetes patients. In 1982, Shichiri et al succeeded in miniaturizing the glucose monitoring system into needle-type glucose sensor, and then we developed a wearable artificial endocrine pancreas (WAEP) which consisted of a needle-type glucose sensor, a microcomputer system, and a insulin infusion pump.
In this study, in order to develop a new WAEP system for long-term clinical application in ambulatory diabetes patients, One problem should be solved ; It is the development of a reliable, stable and miniaturized glucose monitoring system,
Then, we developed a newly designed micro needle-type glucose sensor using flexible polyimide, named PI sensor (outer diameter, 0.3 mm ; length, 16 mm), and investigated its characteristics in vitro and in vivo.
Furthermore, by using this sensing system, we estimated the correlation and the time delay between subcutaneous tissue glucose concentrations and blood glucose concentrations. As a result, excellent characteristics of PI sensor were observed in vitro, and the correlation and the time delay between subcutaneous tissue (Y : mg/100ml) and blood glucose concentrations (X : 30-350 mg/100ml) was Y=1.03X+7.98 (r=0.969) and 6.6 ± 1.2 minutes, respectively.
Furthermore, to evaluate the feasibility of a new WAEP system consisted of a PI sensor for sensing system and new algorithm for control system, glucose control after oral glucose load of 1.5 g/kg was tried in diabetic dogs. By using this system, excellent glucose control (post-challenge blood glucose levels of 178.2 ± 19.3 mg/100ml at 75 min and 83.6 ± 11.8 mg/100ml at 240 min, respectively) could be achieved without any hypoglycemia (below 60 mg/100ml). Thus, by using a new WAEP system, it is expected that closed-loop insulin delivery system will be used widely in diabetes patients, and long-term perfect glucose control be achieved.

  • Research Products

    (8 results)

All 2006 2005 2004

All Journal Article (6 results) Book (2 results)

  • [Journal Article] Developemnt of a highly responsive needli-type glucose sensor using polyimide for a wearable artificial endocrine pancreas.2006

    • Author(s)
      S.Ichimori, et al.
    • Journal Title

      J. Artif. Organs (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Development of a highly responsive needle-type glucose sensor using polyimide for a wearable artificial endocrine pancreas.2006

    • Author(s)
      S.Ichimori, K.Nishida, S.Simoda, T.Sekigami, Y.Matsuo, K.Ichinose, M.Shichiri, M.Sakakida, E.Araki
    • Journal Title

      J.Artif.Organs (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 人口臓器-最近の進歩2004

    • Author(s)
      榊田典治ほか
    • Journal Title

      人口臓器 33(3)

      Pages: 210-214

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 携帯型人口膵島の開発状況2004

    • Author(s)
      榊田典治ほか
    • Journal Title

      Medical Science Digest 30(14)

      Pages: 76-79

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Comparison between closed-loop portal and venous insulin delivery systems for an artificial endocrine panceeas.2004

    • Author(s)
      T.Sekigami, et al.
    • Journal Title

      J. Artif. Organs 7

      Pages: 91-100

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Comparison between closed-loop portal and venous insulin delivery systems for an artificial endocrine pancreas.2004

    • Author(s)
      T.Sekigami, S.Simoda, K.Nishida, Y.Matsuo, S.Ichimori, K.Ichinose, M.Shichiri, M.Sakakida, E.Araki
    • Journal Title

      J.Artif.Organs 7

      Pages: 91-100

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 先端医療シリーズ37 人口臓器・再生医療の最先端 人口膵島2005

    • Author(s)
      榊田典治ら
    • Total Pages
      332
    • Publisher
      先端医療技術研究所
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 糖尿病治療の進歩と新展開[新しい治療]人口膵島2004

    • Author(s)
      榊田典治ら
    • Total Pages
      210
    • Publisher
      診断と治療社
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi