2005 Fiscal Year Final Research Report Summary
Hemodynamic and sinusoidal function change during multistep hepatocarcinogenesis : evaluation by contrast harmonic imaging
| Project/Area Number |
16500326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kinki University |
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Principal Investigator |
KUDO Masatoshi Kinki University, School of Medicine, Professor, 医学部, 教授 (10298953)
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| Co-Investigator(Kenkyū-buntansha) |
MUNAKATA Hiroshi Kinki University, School of Medicine, Professor, 医学部, 教授 (90111294)
FUKUNAGA Toyokazu Kinki University, School of Medicine, Assistant Professor, 医学部, 講師 (90330315)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Hepatocellular Carcinoma / Dysplastic nodule / Pure arterial phase imaging / Nodule-in-nodule HCC / Vascular imaging / Early hepatocellular carcinoma / Arterial flow / Portal flow |
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| Research Abstract |
Hepatocarcinogenesis is a multistep process, evolving from a hyperplastic nodule to early HCC, through early overt HCC, eventually to advanced overt hypervascular HCC. During this process, changes in intranodular hemodynamics also occur. We clarified in this research that at the initial phase of carcinogenesis, the hemodynamic pattern shows arterial vascularity with hypovascular and portal perfusion (type I). In the next step, both arterial and portal blood supplies decrease (type II). Subsequently, intranodular arterial vascularity increases to isovascularity (type III), and then to hypervascularity (type IV). Another hemodynamic transition occurs from the initial pattern to nodule-in-nodule pattern (arterial vascularity with regional vascular spots in a hypovascular background of portal perfusion (type V).
Pure arterial phase imaging has been developed by a development of several technologies including Raw data management technology and accumulation image technology (MIP image). By this method, separate analysis of intranodular, portal flow from arterial flow has been possible, which is a novel technique. This was not possible by CT or MRI. Hepatocellular carcinoma, dysplastic nodule, and nodule-in-nodule type HCC can be successfully diagnosed by using this technique, pure arterial phase imaging.
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[Journal Article] Multicentric occurrence of HCC detected 3-4 years after AFP L3 positivity.2006
Author(s)
Kim SR, Taniguchi M, Sasase N, Kim KI, Ninomiya T, Imoto S, Ando K, Mita K, Fuki S, Fukuda K, Kudo M, Sakamoto H, Inui K, Hayashi Y
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Journal Title
Internal Medicine (in press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Primary sclerosing cholangitis and hepatitis C virus infection.2005
Author(s)
Kim SR, Imoto S, Taniguchi M, Kim KI, Sasase N, Matsuoka T, Maekawa Y, Ninomiya T, Ando K, Mita K, Fuki S, Koterazawa T, Fukuda K, Kudo M, Sakamoto H, Hayashi Y
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Journal Title
Intervirology 48
Pages: 268-272
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Multiple hypervascular liver nodules in a heavy drinker of alcohol2005
Author(s)
Kim SR, Maekawa Y, Ninomiya T, Imoto S, Matsuoka T, Ando K, Mita K, Ku K, Koterazawa T, Nakajima T, Fukuda K, Yano Y, Nakaji M, Kudo M, Kim KI, Hirai M, Hayashi Y
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Journal Title
J Gastroenterol Hepatol 20
Pages: 795-799
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Well-differentiated HCC manifesting hyperattenuation on CT during arterial portography.2005
Author(s)
Kim SR, Kim KI, Maekawa Y, Imoto S, Ninomiya T, Mita K, Ando K, Fukuda K, Kudo M, Matsuoka T, Hayashi Y, Sasase N, Taniguchi M
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Journal Title
Hepato Gastroenterology 52
Pages: 1559-1562
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Characterization of hepatic tumors : value of contrast-enhanced coded phase inversion harmonic US.2004
Author(s)
Wen YL, Kudo M, Zheng RQ, Ding H, Minami Y, Chung H, Suetomi Y, Onda H, Kitano M, Kawasaki T, Maekawa K
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Journal Title
AJR 182(4)
Pages: 1019-1026
Description
「研究成果報告書概要(欧文)」より
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