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2005 Fiscal Year Final Research Report Summary

Cardiolipin functions in fish polyunsaturated fatty acid metabolism through plasma lipoproteins

Research Project

Project/Area Number 16580165
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fisheries chemistry
Research InstitutionTohoku University

Principal Investigator

YAMAGUCHI Toshiyasu  Tohoku University, Graduate School of Agricultural Science, Associate Professor, 大学院・農学研究科, 助教授 (90167700)

Project Period (FY) 2004 – 2005
KeywordsCardiolipin / Plasma lipoprotein / Polyunsaturated fatty acids / Docosahexaenoic acid / Cholesterol / HDL / Phospholipids
Research Abstract

Radioactive docosahexaenoic acid (DHA) was injected using with the fiberscope into the carp intestine and the fatty acid was incorporated into phospholipids. The DHA was immediately detected in the hepatopancreas.
Radioactive docosahexaenoic acid was detected in plasma lipoprotein after injection but radioactive eicosapentaenoic acid (EPA) was detected only small amounts. And DHA was incorporated into leukocyte cardiolipin but EPA and arachidonic acid were not incorporated into carp cardiolipin.
In this research the activities of cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP) were clarified in carp plasma using the radioactive polyunsaturated fatty acid 8PUFA9. Cardiolipin was not detected in fish plasma lipoprotein, but in blood cells especially leukocytes cardiolipin was detected and DHA was incorporated into cardiolipin. It is suggested that cardiolipin was important component for the function of DHA in the fish blood cells.

  • Research Products

    (2 results)

All 2004

All Journal Article (2 results)

  • [Journal Article] 魚類の血漿リポタンパク質代謝2004

    • Author(s)
      山口 敏康
    • Journal Title

      日本水産学会誌 70(5)

      Pages: 766-767

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Metabolism of plasma lipoprotein in fishes2004

    • Author(s)
      Toshiyasu YAMAGUCHI
    • Journal Title

      NIPPON SUISAN GAKKAISHI 70(5)

      Pages: 766-767

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

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