2005 Fiscal Year Final Research Report Summary
Search for new cell cycle inhibitors from marine organisms
| Project/Area Number |
16590005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
TSUKAMOTO Sachiko Kanazawa University, Graduate School of Natural Science and Technology, Associate Professor, 自然科学研究科, 助教授 (40192190)
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| Project Period (FY) |
2004 – 2005
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| Keywords | proteasome / ubiuitin activating enzyme / ubiquitin ligase / p53 / HDM2 / marine organisms / antitumor compounds / ubiquitin dependent protein degradation system |
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| Research Abstract |
The marine invertebrate has proven to be a rich source of extremely potent compounds that have demonstrated significant activities in antitumor, anti-inflammatory, analgesia, immunomodulation, allergy, and antiviral assays. In this study, we searched for new cell cycle inhibitors from marine organisms, by using assays of cytotoxicity and flow cytometric analysis. The ubiquitin-proteasome system plays important roles in various cellular events, including cell cycle progression, transcriptional regulation, and signal transduction. Then, we search for inhibitors of the ubiquitin-activating enzyme (E1), the ubiquitin ligase (E3), and the proteasome, and found several compounds which inhibit the enzymes.
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[Journal Article] Marine Sponge2005
Author(s)
Sachiko Tsukamoto
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Journal Title
Biotechnological Applications of Marine Natural Substances
Pages: 60-81
Description
「研究成果報告書概要(欧文)」より
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