2006 Fiscal Year Final Research Report Summary
An integrative study on the role of spinal cord in neural mechanisms involved in mental sweating of humans.
| Project/Area Number |
16590183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Aichi Medical University |
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Principal Investigator |
SUGENOYA Junichi Aichi Medical University, School of Medicine, Professor (50109352)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Takaaki Aichi Medical University, School of Medicine, Associate Professor (60199875)
IWASE Satoshi Aichi Medical University, School of Medicine, Associate Professor (90184879)
NISHIMURA Naoki Aichi Medical University, School of Medicine, Assistant Professor (40278362)
INUKAI Yoko Aichi Medical University, School of Medicine, Assistant Professor (10308950)
SATO Maki Aichi Medical University, School of Medicine, Research Associate (60351102)
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| Project Period (FY) |
2004 – 2006
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| Keywords | electroacupuncture / spinal cord / mental sweating / skin pressure reflex / skin sympathetic nerve activity / mental stress |
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| Research Abstract |
Roles of spinal cord in neural mechanisms involved in mental sweating were studied by skin pressure (SP) and acupuncture stimulation (AS). Series I: the pattern of the suppression of sweating on palm and sole elicited by SP was examined. When 13 skin sites on the lateral body line located from head to hock were pressed, palmar sweating was suppressed ispsilaterally by pressure at C3 to L3 segmental levels, confirming that SP suppresses palmar sweating, as well as thermal sweating, via spinal mechanisms. Series II: AS at 5Hz and 100Hz is known to suppress palmar and plantar sweating via the mechanisms located below the higher center for sweating. To determine whether the site of action is located at spinal cord or sweat gland, we examined the responsiveness of sweat glands to neural activities by analyzing skin sympathetic nerve activity (SSNA), which was recoded by a microelectrode technique. The correlation between the rate of rise of sweat expulsion and the amplitude of the corresponding SSNA burst revealed that the slope of the regression line was not altered by AS at 5Hz or 100Hz. This substantiates that AS acts on spinal mechanisms. Series III: AS frequencies effective in sweat-suppression were examined. AS at 25Hz suppressed sweating via higher central mechanisms, whereas that at 300Hz failed to suppress it. Series IV: effects of AS on cutaneous blood flow (CBF) were examined. AS at 5Hz and 100Hz suppressed CBF on the sole, whereas they failed to suppress on the palm. It was concluded that spinal cord exhibits integrative functions as the centers of spinal reflex. Probably, sensory signals originating from various type of mechanoreceptor enter intermediolateral neurons in spinal cord, and modify the descending sympathetic signals at same segmental levels. However, integrative mechanisms may be different between regulatory functions.
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[Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity.2006
Author(s)
Daisuke Michikami, Atsunori Kamiya, Toru Kawasa, Masashi Inagaki, Toshiaki Shindo, Kenta Yamamoto, Hideto Ariumi, Satoshi Iwase, Junichi Sugenoya, Kenji Sunagawa, Masaru Sugimachi
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Journal Title
Am J Physiol Circ Physiol 291
Pages: H318-H326
Description
「研究成果報告書概要(欧文)」より
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