2005 Fiscal Year Final Research Report Summary
Genetic alteration and cellular mucin phenotype of ulcerative colitis-associated colorectal carcinoma
| Project/Area Number |
16590270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Niigata University |
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Principal Investigator |
AJIOKA Yoichi Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (80222610)
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| Project Period (FY) |
2004 – 2005
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| Keywords | ulcerative colitis / colorectal carcinoma / cancerization / dysplasia / mucin phenotype / p53 / MSI |
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| Research Abstract |
1. p53 alteration was found in 3/4 colitic cancer and 4/4 dysplasia.
2. 5/8 colitic cancers and 4/6 dysplasia demonstrated MUC2+/MUC5AC+ mucin phenotype
3. Background colonic mucosa of colitic cancer revealed diffuse expression of MUC5AC
4. In 5 cases of colitc cancer, no MSI status was found in cancer nor in their background mucosa
Carcinogenesis in ulcerative colitis was thought as ; chronic persistent inflammation→cellular mucin phenotype conversion of the stem cell in the crypt→development of dysplasia→progression to carcinoma.
To elucidate further mechanism underlying the cancerization in ulcerative colitis, it is required to analyze the genetic changes responsible for cellular phenotype conversion of the stem cell.
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