2005 Fiscal Year Final Research Report Summary
Analyses for abnormality of cell cycle regulator molecules and their degradation pathways, in solid carcinomas and application to clinical medicine.
| Project/Area Number |
16590272
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
DOBASHI Yoh University of Yamanashi, Department of Research, Interdisciplinary Graduate School of Medicine and Engineering, Associate Professor, 大学院・医学工学総合研究部, 助教授 (90231456)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Shioto University of Yamanashi, Department of Research, Interdisciplinary Graduate School of Medicine and Engineering, Research Associate, 大学院・医学工学総合研究部, 助手 (40334859)
WATANABE Hideomi Gunma University, School of Medicine, Professor, 医学部, 教授 (40231724)
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| Project Period (FY) |
2004 – 2005
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| Keywords | cell cycle molecules / soft tissue sarcomas / lung carcinoma / apoptosis / EGFR / gene amplification / autocrine motility factor |
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| Research Abstract |
We have reported several diverse functions and abnormality of cell cycle regulator molecules in cultured cells and in human tumors. In the research during this term, analysis in correlation with aberration of oncogens was performed in soft tissue sarcomas, carcinomas of gastrointestinal tract and the lung. We clarified the followings.
i) Overexpression of cyclin D1 or ccdk4, which cause apoptosis in cultured cells, also caused apoptosis in lung carcinoma in vivo and it correlates with prognosis (Int.J.Cancer, 2004, Pathol.Int, 2005).
ii) Epidermal growth factor receptor (EGFR) is overexpressed in 10 to 15% of the cases in carcinomas of gastrointestinal tract, and overexpression is predominantly caused by gene amplification (Mod.Pathol. 2004, J.Pathol. 2005, Int.J.Cancer 2006).
iii) Overexpression of EGFR was observed in 1% of bone and soft tissue sarcomas, and those cases were exclusively associated with gene abnormality, i.e., amplification and polysomy (Mod.Pathol. 2004).
iv) By reviewing all resected cases of lung carcinomas in University of Yamanashi Hospital in the past 10 years, we found and reported that bronchioloalveolar carcinoma, newly defined in WHO classification (3rd Edition, 1999) never recur nor metastasize (Ann Thorac Surg, 2004).
v) Invasion-related protein, autocrine motility factor (AMF) were found to be expressed in 72.5% of the benign and malignant soft tissue tumors. The tumor expressing high level of mRNA and secreting AMF at high amount were found to be the cases showing high metastatic probability.
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Research Products
(18 results)
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[Book] シンプル病理学2004
Author(s)
笹野 公典
Total Pages
400
Publisher
南江堂
Description
「研究成果報告書概要(和文)」より
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