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2005 Fiscal Year Final Research Report Summary

Analysis of correlation between VCP expression and metastasis in human cancers

Research Project

Project/Area Number 16590276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionOsaka University

Principal Investigator

TOMITA Yasuhiko  Osaka Univ., Grad.Sch.Med., Assoc.Prof., 医学系研究科, 助教授 (60263266)

Co-Investigator(Kenkyū-buntansha) HOSHIDA Yoshihiko  Osaka Univ., Hosp., Assoc.Prof., 医学部附属病院, 助教授 (40324777)
AOZASA Katsuyuki  Osaka Univ., Grad.Sch.Med., Prof., 医学系研究科, 教授 (30115985)
Project Period (FY) 2004 – 2005
KeywordsValosin-containing protein / metastasis / transcription factor / prognosis
Research Abstract

The researchers have identified that Valosin-containing protein (VCP) to be correlated with the metastasis of a murine osteosarcoma cell line by using the mRNA subtraction technique. This project was designed to identify whether or not VCP expression level in cancer cells was correlated with the rate of recurrence and prognosis of patients with cancer and clarify the transcriptional mechanism of VCP. The result showed that VCP expression is correlated with the progression and prognosis of cancers arising from lung, prostate, pancreatic endocrine, esophagus, gingiva, and thyroid. (Ann.Surg.Oncol.2004;11:697-704,Clin.Cancer Res.2004;10:3007-3012,Oncol.2004;66:468-475, Ann. Oncol. 2004;15:1432-1438,Clin.Cancer. Res.2004;10:5558-5565, Ann. Surg. Oncol. 2005;12:925-934) Transcriptional activity of VCP gene was analyzed by Luciferase reporter assay. Luciferase reporter assay revealed two candidate transcription factors, PBX1 and ELF2 which might be important in VCP transcription. Chromatin immunoprecipitation assay revealed the binding of PBX1 and ELF2 to the 5' flanking region DNA sequence. Cellular knock-down of PBX1 and ELF2 expression with siRNA transfection led decrease and increase of VCP expression, respectively. These findings indicate that PBX1 and ELF2 are important transcription factors for VCP expression.

  • Research Products

    (12 results)

All 2005 2004

All Journal Article (12 results)

  • [Journal Article] Expression of Valosin containing protein (p97) is associated with disease recurrence of follicular thyroid cancer.2005

    • Author(s)
      Yamamoto S, Tomita Y, et al.
    • Journal Title

      Ann.Surg.Oncol. 12

      Pages: 925-935

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prognostic significance of BACH2 expression in diffuse large B-cell lymphoma.2005

    • Author(s)
      Sakane-Ishikawa E, Tomita Y, et al.
    • Journal Title

      J.Clin.Oncol. 23

      Pages: 8012-8017

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Increased Expression of Valosin-containing Protein (p97) is Correlated with disease recurrence in Follicular Thyroid Cancer.2005

    • Author(s)
      Yamamoto S, Tomita Y, Uruno T, Hoshida Y, Qiu Y, Iizuka N, Monden M, Miyauchi A, Aozasa K.
    • Journal Title

      Ann Surg Oncol. 12

      Pages: 925-935

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prognostic significance of BACH2 expression in diffuse large B-cell lymphoma.2005

    • Author(s)
      Sakane-Ishikawa E, Nakatsuka S, Tomita Y, Fujita S, Nakamichi I, Takakuwa T, Sugiyama H, Fukuhara S, Hino M, Kanamaru A, Soma T, Tsukaguchi M, Igarashi K, Kanakura Y, Aozasa K, Osaka Lymphoma Study Group
    • Journal Title

      J Clin Oncol 23

      Pages: 8012-8017

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression level of Valosin-containing protein (p97) is correlated with progression and prognosis of nonsmall cell lung carcinoma.2004

    • Author(s)
      Yamamoto S, Tomita Y, et al.
    • Journal Title

      Ann.Surg.Oncol. 11

      Pages: 697-704

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Elevated expression of Valosin-containing protein (p97) is associated with poor prognosis of prostate cancer.2004

    • Author(s)
      Tsujimoto Y, Tomita Y, et al.
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 3007-3012

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression level of Valosin-containing protein (VCP) is associated with progression and prognosis of esophageal carcinoma.2004

    • Author(s)
      Yamamoto S, Tomita Y, et al.
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 5558-5565

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression level of Valosin-containing protein (VCP) as a prognostic marker for Gingival Squamous Cell Carcinoma.2004

    • Author(s)
      Yamamoto S, Tomita Y, et al.
    • Journal Title

      Ann.Oncol. 15

      Pages: 1432-1438

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Increased expression of valosin containing protein (VCP : p97), a member of the ATPase, is associated with lymph node metastasis in pancreatic adenocarcinoma.2004

    • Author(s)
      Yamamoto S, Tomita Y, Hoshida Y, Nagano H, Dono K, Umeshita K, Sakon M, Ishikawa O, Ohigashi H, Nakamori S, Monden M, Aozasa K.
    • Journal Title

      Ann.Surg.Oncol. 11

      Pages: 697-704

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Elevated expression of Valosin-containing protein (p97) is associated with poor prognosis of prostate cancer.2004

    • Author(s)
      Tsujimoto Y, Tomita Y, Hoshida Y, Kono T, Oka T, Yamamoto S, Nonomura N, Okuyama A, Aozasa K.
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 3007-3012

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression level of Valosin-containing protein (VCP) is associated with progression and prognosis of esophageal carcinoma.2004

    • Author(s)
      Yamamoto S, Tomita Y, Hoshida Y, Iizuka N, Kidogami S, Takiguchi Y, Fujiwara Y, Yasuda T, Yano M, Nakamori S, Sakon M, Monden M, Aozasa K.
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 5558-5565

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression level of Valosin-containing protein (VCP) as a prognostic marker for Gingival Squamous Cell Carcinoma.2004

    • Author(s)
      Yamamoto S, Tomita Y, Hoshida Y, Toyosawa S, Inohara H, Kishino M, Kogo M, Nakazawa M, Murakami S, Iizuka N, Kidogami S, Monden M, Kubo T, Ijuhin N, Aozasa K.
    • Journal Title

      Ann.Oncol. 15

      Pages: 1432-1438

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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