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2004 Fiscal Year Annual Research Report

老人性EBV関連B細胞リンパ増殖異常症の臨床病理学的、分子生物学的研究

Research Project

Project/Area Number 16590301
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

中村 栄男  愛知県がんセンター, 研究所, 研究員 (80180363)

KeywordsAging / Immune senescence / diifuse large B-cell lymphoma / Epstein-Barr virus / Hodgkin lymphoma / Lymphoproliferative disorder / Immunodeficiency / WHO classification
Research Abstract

我々は、最近、老人性EBV関連B細胞リンパ増殖症Senile EBV-associated B-cell lymphoproliferative disorderの疾患概念を世界に先駆けて公表し(Am J Surg Pathol 2003;27:16)、認知せしめるに至った。加齢による免疫機能の低下を背景として発症する特異な疾患であり、治療としてインターフェロンなど免疫療法immunomodulation therapyが奏効する可能性が示唆される。本疾患は、今後前例のない高齢化社会に向かう本邦において、発生の急速な増加が懸念される疾病と云える。本研究の目的は、その病態と背景要因の詳細な解明を企図したものであり、本邦集学的な解析(臨床病理学的、分子生物学的、免疫学的および疫学的検討)を推し進めつつある。東京大学医科学研究所、福島大学、岡山大学、福岡大学などの協力を仰ぎ、びまん性B大細胞型リンパ腫を中心とする本邦大規模B細胞増殖症2,300例におけるin situ hybridization法によるEBVの有無の調査を継続して行った。その結果、150例に達する同陽性症例を同定し得た。現在、臨床経過、予後、および治療反応性を含む臨床病理学的解析を進めつつある。現在、個々の個体レベルでのEBVに対する免疫能を調べるために、患者末梢血におけるPCRによるEBVウイルスゲノム量の測定、EBV-specific T細胞の定量のための日本人HLAに依拠したtetramer開発、およびlymphoblastopid cell line (LCL)を用いたT細胞によるinterfern γ産生能測定のための体制を整備中である。本研究により加齢と発がんとの相関に関する知見の大いなる深化が期待できるものといえる。

  • Research Products

    (18 results)

All 2005 2004

All Journal Article (16 results) Book (2 results)

  • [Journal Article] Genome-wide array-based CGH for mantle cell lymphoma : identification of homozygous deletions of the proapoptotic gene BIM.2005

    • Author(s)
      Tagawa, H., et al.
    • Journal Title

      Oncogene (in press)

  • [Journal Article] p16/ INK4a gene methylation is a frequent finding in pulmonary MALT lymphomas at diagnosis.2005

    • Author(s)
      Takino, H., et al.
    • Journal Title

      Mod.Pathol. (in press)

  • [Journal Article] Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy.2005

    • Author(s)
      Taji, S., et al.
    • Journal Title

      World J.Gastroenterol. 11

      Pages: 89-93

  • [Journal Article] Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma.2004

    • Author(s)
      Kameoka, Y., et al.
    • Journal Title

      Oncogene 23

      Pages: 9148-9154

  • [Journal Article] Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter pylori eradication and detection of API2-MALT1 fusion2004

    • Author(s)
      Inagaki, H., et al.
    • Journal Title

      Am.J.Surg.Pathol. 28

      Pages: 1560-1567

  • [Journal Article] Methylenetetrahydrofolate Reductase Gene (MTHFR) Polymorphisms and Reduced Risk of Malignant Lymphoma.2004

    • Author(s)
      Matsuo, K., et al.
    • Journal Title

      Am.J.Hematol. 77

      Pages: 351-357

  • [Journal Article] Cladribine Study Group. Durable response but prolonged cytopenia after cladribine treatment in relapsed patients with indolent lymphomas.2004

    • Author(s)
      Ogura, M., et al.
    • Journal Title

      Int.J.Hematol. 80

      Pages: 267-277

  • [Journal Article] Effect of hepatitis C virus infection on the risk of non-Hodgkin' s lymphoma : a meta-analysis of epidemiological studies.2004

    • Author(s)
      Matsuo, K., et al.
    • Journal Title

      Cancer Sci. 95

      Pages: 742-752

  • [Journal Article] Detection of t(14;18) in follicular lymphoma by dual-color fluorescence in situ hybridization on paraffin-embedded tissue sections.2004

    • Author(s)
      Matsumoto, Y., et al.
    • Journal Title

      Cancer Gene.Cytogenet. 150

      Pages: 22-26

  • [Journal Article] Genome-Wide Array-Based Comparative Genomic Hybridization of Diffuse Large B-Cell Lymphoima : Comparison between CD5-Positive and CD5-Negative Cases.2004

    • Author(s)
      Tagawa, H., et al.
    • Journal Title

      Cancer Res. 64

      Pages: 5948-5955

  • [Journal Article] CXCR3 and CCR4. Expression, in T-cell and NK-cell lymphomas with Special Reference to Clinicopathological Significance in T-cell Lymphoma.2004

    • Author(s)
      Ishida, T., et al.
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 5494-5500

  • [Journal Article] Aggressive natural killer-cell leukemia revisited : large granular leukemia of cytotoxic NK cells.2004

    • Author(s)
      Suzuki, R., et al.
    • Journal Title

      Leukemia 18

      Pages: 763-770

  • [Journal Article] Pathology review for a paediatric non-Hodgkin's lymphoma patients in Japan : a report from the Japan association of childhood leukaemia study (JACLS).2004

    • Author(s)
      Nakagawa, A., et al.
    • Journal Title

      Eur.J.Cancer 40

      Pages: 725-733

  • [Journal Article] Lack of association between DNA base excision repair gene XRCC1 Gin399Arg polymorphism and risk of malignant lymphoma in Japan.2004

    • Author(s)
      Matsuo, K., et al.
    • Journal Title

      Cancer Genet.Cytogenet. 149

      Pages: 77-80

  • [Journal Article] Intravascular large B-cell lymphoma presenting with mass lesions in the central nervous system : A report of five cases.2004

    • Author(s)
      Imai, H., et al.
    • Journal Title

      Pathol.Int. 54

      Pages: 231-236

  • [Journal Article] Analysis of chromosomal imbalances in de novo CD5-positive diffuse large-B-cell lymphoma detected by comparative genomic hybridization.2004

    • Author(s)
      Karnan, S., et al.
    • Journal Title

      Genes Chromosomes Cancer 39

      Pages: 77-81

  • [Book] Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. World Health Organization Classification of Tumours.2004

    • Author(s)
      Chan, A.C.L., et al.
    • Total Pages
      2
    • Publisher
      Travis, W.D., Brambilla, E., Muller-Hermelink, H.K., Harris, C.C.
  • [Book] Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. World Health Organization Classification of Tumours.2004

    • Author(s)
      Nakamura, S., et al.
    • Total Pages
      1
    • Publisher
      Travis, W.D., Brambilla, E., Muller-Hermelink, H.K., Harris, C.C.

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Published: 2006-07-12   Modified: 2016-04-21  

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