• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Molecular epidemiology of hepatitis E virus in Japan and study on animal host of virus.

Research Project

Project/Area Number 16590331
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

ABE Kenji  National Institute of Infectious Diseases, Department of Pathology, Senior Research Scientist, 感染病理部, 主任研究官 (60130415)

Project Period (FY) 2004 – 2005
KeywordsHepatitis E / HEV / Animal host / International study / 国際研究
Research Abstract

I conducted seroepidemiological studies on antibody prevalence to hepatitis E virus (HEV) in 5,233 sera from 11 countries to ascertain the present state of HEV infection on a global basis. The rate of anti-HEV IgG positivity was as follows : 8.9% in Tokyo and 34.5% in Okinawa of Japan, 62.1% in Hanoi and 41.8% in Ho Chi Minh City of Vietnam, 29.2% in Harbin of China, 27% in Thailand, 35.1% in Myanmar, 66% in Nepal, 21.3% in U.S.A., 34% in Spain, 20.2% in Russia, 80% in Egypt and 12.7% in Bolivia, respectively. The prevalence of anti-HEV IgG increased with age in these tested countries, but the rate of antibody positivity was over 20% in the 16-30 year-old group in most of the participating countries, except for Japan, the U.S.A and Spain. Of patients with acute hepatitis of unknown etiology from Nepal, 56% (14/25) were positive for the IgM class of anti-HEV antibody. In addition, HEV RNAs in the serum from 3 Nepali patients who had the IgM antibody were detected by nested PCR and all of the HEV genes isolated belonged to genotype, 1. Our results indicate that HEV is spreading worldwide not only in developing countries, but also in more industrialized countries than previously thought.

  • Research Products

    (10 results)

All 2006 2005 Other

All Journal Article (10 results)

  • [Journal Article] Characteristic of hepatitis B virus in Ghana: Full length genome sequences indicates the endemicity of genotype E in West Africa.2006

    • Author(s)
      Tran TT Huy, Koichi Ishikawa, William Ampofo, Taku Izumi, Akira Nakajima, Justina Ansah, John O.Tetteh, Nicholas Nii-Trebi, Simeon Aidoo, David Ofori-Adjei, Tetsutaro Sata, Hiroshi Ushijima, Kenji Abe
    • Journal Title

      Journal of Medical Virology 78

      Pages: 178-184

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genomic characterization of HBV genotype F in Bolivia: Genotype F subgenotypes correlate with geographic distribution and T1858 variant.2006

    • Author(s)
      Tran Thien Tuan Huy, Hiroshi Ushijima, Tetsutaro Sata, Kenji Abe
    • Journal Title

      Archives of Virology 151

      Pages: 589-597

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Full length sequence of hepatitis B virus belonging to genotype H identified in a Japanese patient with chronic hepatitis.2005

    • Author(s)
      Akira Nakajima, et al.
    • Journal Title

      Japanese Journal of Infectious Diseases 58

      Pages: 244-246

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A novel recombinant of hepatitis B virus genotype G and C isolated from a Thai patient with hepatocellular carcinoma.2005

    • Author(s)
      Suwannakarn K, et al.
    • Journal Title

      Journal of General Virology 86

      Pages: 3027-3030

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Full length genome sequences indicates the endemicity of genotype E in West Africa.2005

    • Author(s)
      Tran TT Huy, et al.
    • Journal Title

      Journal of Medical Virology 78

      Pages: 178-184

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Genotype F subgenotypes correlate with geographic distribution and T1858 variant.2005

    • Author(s)
      Tran TT Huy, et al.
    • Journal Title

      Archives of Virology 151

      Pages: 589-597

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Full length sequence of hepatitis B virus belonging to genotype H identified in a Japanese patient with chronic hepatitis.2005

    • Author(s)
      Akira Nakajima, Mitsugu Usui, Tran Thien Tuan Huy, Naomi Khaing Than Hlaing, Naohiko Masaki, Tetsutaro Sata, Kenji Abe
    • Journal Title

      Japanese Journal of Infectious Diseases 58

      Pages: 244-246

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A novel recombinant of hepatitis B virus genotype G and C isolated from a Thai patient with hepatocellular carcinoma.2005

    • Author(s)
      Suwannakarn K, Tangkijavanich P, Theamboonlers A, Abe K, Poovorawan Y.
    • Journal Title

      Journal of General Virology 86

      Pages: 3027-3030

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] International collaborative survey on epidemiology of hepatitis E virus in 11 countries.

    • Author(s)
      Kenji Abe, et al.
    • Journal Title

      Southeast Asian Journal of Tropical Medicine and Public Health (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] International collaborative survey on epidemiology of hepatitis E virus in 11 countries.

    • Author(s)
      Kenii Abe, Xin Ding, Tian-Cheng Li, Naokazu Takeda, Khin Maung Win, Pradeep Krishna Shrestha, Vo Xuan Quang, Trinh Thi Ngoc, Teresa Casanovas Taltavull, Andrei V.Smirnov, Vasily F.Uchaikin, Pairoj Luengrojanakul, Hongxi Gu, Abdel Rahman El-Zayadi, Alfred M.Prince, Naohiko Masaki, Kaoru Kikuchi, Tetsutaro Sata
    • Journal Title

      Southeast Asian Journal of Tropical Medicine and Public Health (in press)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi