2005 Fiscal Year Final Research Report Summary
Induction of oral tolerance by plasmacytoid dendritic cells in the intestinal lamina propria
| Project/Area Number |
16590399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIROI Takachika The University of Tokyo, The Institute of Medical Science, Department of Mucosal Immunology, Research Associate, 医科学研究所, 助手 (80228824)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Mucosal immunology / Intestinal lamina propria / Oral tolerance / Eosinophil / Dendritic cells / Regulatory T cells / TGF-β / IgA |
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| Research Abstract |
We have identified a novel subset of eosinophils in the intestinal lamina propria which are capable of expressing morphological and functional characteristics of dendritic cells. These eosinophils, which express Gr-1^+CD11c^+F4/80^+CD11b^+B220^- surface phenotypic markers, can initiate inhibition from their site of residence and so play a pivotal role in the induction of oral tolerance that is independent of CD4^+CD25^+ T regulatory cell-mediated inhibitory effects. When activated with CpG/Flt3-L, intestinal eosinophils acquire typical dendritic morphology and confer an antigen-specific T cell unresponsiveness that is dependent on their low expression of co-stimulatory molecules and increased production of TGF-β.
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