2005 Fiscal Year Final Research Report Summary
Effects of morphine-related genotypes on the individualized morphine treatment in cancer patients
| Project/Area Number |
16590436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Oita University (2005)
Hamamatsu University School of Medicine (2004) |
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Principal Investigator |
OHASHI Kyoichi Oita University, Faculty of Medicine, professor, 医学部, 教授 (20137714)
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| Co-Investigator(Kenkyū-buntansha) |
EGUCHI Kenji Tokai University, Faculty of Medicine, professor, 医学部, 教授 (30349336)
HYODO Ichinosuke University of Tsukuba, Graduate school, professor, 大学院, 教授 (60416469)
UCHIDA Shinya University of Shizuoka, School of Pharmaceutical Science, assistant professor, 薬学部, 講師 (80372522)
KOTEGAWA Tsutomu Oita University, Faculty of Medicine, assistant professor, 医学部, 助教授 (20264343)
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| Project Period (FY) |
2004 – 2005
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| Keywords | morphine / pharmacogenetics / opioid receptor |
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| Research Abstract |
Morphine is the most important and widely used opioid analgesics. The interindividual differences in its pharmacokinetics and in its adverse effects are major limitations for individualized pain treatment. We have observed a wider interindividual difference in plasma M3G/morphine ratio after both oral and intravenous administration of morphine. However, we did not observed a pharmacogenetic effect of UGT2B7. The human μ-opioid receptor, which is coded by the OPRM1 gene is a primary candidate for the clinical outcome. Several candidate gene analysis in 12 cancer patients were performed during morphine therapy. The adverse effects of morphine, drowsiness or confusion, was observed frequently in homozygous carriers of the mutated G118 allele of OPRM1.
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