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2005 Fiscal Year Final Research Report Summary

Effects of morphine-related genotypes on the individualized morphine treatment in cancer patients

Research Project

Project/Area Number 16590436
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionOita University (2005)
Hamamatsu University School of Medicine (2004)

Principal Investigator

OHASHI Kyoichi  Oita University, Faculty of Medicine, professor, 医学部, 教授 (20137714)

Co-Investigator(Kenkyū-buntansha) EGUCHI Kenji  Tokai University, Faculty of Medicine, professor, 医学部, 教授 (30349336)
HYODO Ichinosuke  University of Tsukuba, Graduate school, professor, 大学院, 教授 (60416469)
UCHIDA Shinya  University of Shizuoka, School of Pharmaceutical Science, assistant professor, 薬学部, 講師 (80372522)
KOTEGAWA Tsutomu  Oita University, Faculty of Medicine, assistant professor, 医学部, 助教授 (20264343)
Project Period (FY) 2004 – 2005
Keywordsmorphine / pharmacogenetics / opioid receptor
Research Abstract

Morphine is the most important and widely used opioid analgesics. The interindividual differences in its pharmacokinetics and in its adverse effects are major limitations for individualized pain treatment. We have observed a wider interindividual difference in plasma M3G/morphine ratio after both oral and intravenous administration of morphine. However, we did not observed a pharmacogenetic effect of UGT2B7. The human μ-opioid receptor, which is coded by the OPRM1 gene is a primary candidate for the clinical outcome. Several candidate gene analysis in 12 cancer patients were performed during morphine therapy. The adverse effects of morphine, drowsiness or confusion, was observed frequently in homozygous carriers of the mutated G118 allele of OPRM1.

  • Research Products

    (6 results)

All 2005 2004 2003

All Journal Article (6 results)

  • [Journal Article] モルヒネの薬効におけるμ受容体遺伝子多型2005

    • Author(s)
      立石正登, 内田信也, 江口研二, 兵頭一之介, 大橋京一
    • Journal Title

      臨床薬理 36 Suppl

      Pages: 185

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effect of opioid- μ receptor genotype on clinical effect of morphine2005

    • Author(s)
      Tateishi M, Uchida S, Eguchi K, Hyodo I, Oashi K
    • Journal Title

      Jap J Clin Pharmacol Ther 36 Suppl

      Pages: 185

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] モルヒネ効果の個人差は酵素や受容体の遺伝子多型が関与か2004

    • Author(s)
      大橋京一, 立石正登
    • Journal Title

      メディカル朝日 9月号

      Pages: 40-41

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Are polymorphism of metabolized enzyme and receptor influenced interindividual effect of morphine?2004

    • Author(s)
      Ohashi K, Tateishi M
    • Journal Title

      Medical Asahi Sep.

      Pages: 40-41

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Interindividual variation in the ratio between plasma morphine and its metabolites in cancer patients.2003

    • Author(s)
      Tateishi M, Ohashi K, Kobayashi K, Hashimoto T, Yamaguchi J, Fujioka H, Izawa K, Masada M
    • Journal Title

      Int J Clin Pham Res 23

      Pages: 75-82

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Interindividual variation in the ratio between plasma morphine and its metabolites in cancer patients.2003

    • Author(s)
      Tateishi M, Ohashi K, Kobayashi K, Hashimoto T, Yamaguchi J, Fujioka H, Izawa K, Masada M
    • Journal Title

      Int J Clin Pharm Res 23

      Pages: 75-82

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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