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2005 Fiscal Year Final Research Report Summary

DNA-based diagnosis on responsibility for anticancer drugs by methylation-specific PCR for BCRP

Research Project

Project/Area Number 16590437
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionNagasaki University

Principal Investigator

TSUKAMOTO Kazuhiro  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (30253305)

Co-Investigator(Kenkyū-buntansha) SODA Hiroshi  Nagasaki University, Hospital of medicine and Dentistry, Associate Professor, 医学部・歯学部附属病院, 助教授 (60244042)
Project Period (FY) 2004 – 2005
KeywordsBreast cancer resistance protein : BCRP / Methylation / Methylation-specific PCR / Prediction for responsibility of anticancer drugs / DNA-based diagnosis / Irinotecan : CPT-11 / Lung cancer / Colorectal cancer
Research Abstract

Breast cancer resistant protein (BCRP) functions as a drug efflux transporter that mediates drug resistance. Topoisomerase I inhibitors including SN-38 (an active metabolite of irinotecan) are substrates effluxed by BCRP. The underlying mechanisms for overexpression of BCRP during acquisition of drug resistance remain unclear. Then, treatment of non-BCRP-expressing small-cell lung cancer cells, PC-6, with DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, induced BCRP re-expression at the mRNA and protein levels. Bisulfite sequencing analysis and subsequent comparisons between bisulfite-modified and unmodified DNA sequences at CpG sites in the promoter region of BCRP revealed that both alleles at all 89 CpG sites were completely methylated in PC-6, while those at 79 CpG sites in BCRP-expressing resistant small-cell lung cancer cells, PC-6/SN2-5H, were unmethylated. These results indicate a correlation between demethylation of the promoter region of BCRP and BCRP re-expression, an … More d suggest one of mechanisms for SN-38 drug resistance.
Next, a methylation-specific PCR (MSP) method for BCRP was established based on the sequences of BCRP in the methylated and methylated regions. MSP method revealed an inverse correlation between methylation status of the promoter region of BCRP and expression of BCRP mRNA in several lung cancer cell lines (in vitro) and lung and colorectal cancers resected on operation (in vivo).
As a cohort study, an association of methylation status of the promoter region of BCRP using MSP for biopsy specimens of lung cancer patients before chemotherapy with the responsibility for anticancer drugs was examined. This DNA-based diagnosis revealed that the sensitivity was 83.3% and the specificity was 77.8%. This study implies that it is very useful as a new biomarker in predicting drug resistance and responsibility for anticancer drugs to examine methylation status of the promoter region of BCRP using MSP for not only lung cancers, but also colorectal cancers, gastric cancers, breast cancers, ovarian tumors, and choriocarcinomas. Less

  • Research Products

    (82 results)

All 2006 2005 2004

All Journal Article (66 results) Book (16 results)

  • [Journal Article] Effects of short interfering RNA against methicillin-resistant Staphylococcus aureus coagulase in vitro and in vivo.2006

    • Author(s)
      Yanagihara K, Tsukamoto K, et al.
    • Journal Title

      J Antimicrob Chemother 57(1)

      Pages: 122-126

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] In vivo efficacies and pharmacokinetics of DX-619, a novel des-fluoro(6) quinolone, against Streptococcus pneumoniae in a mouse lung infection model.2006

    • Author(s)
      Fukuda Y, Tsukamoto K, et al.
    • Journal Title

      Antimicrob Agents Chemother 50(1)

      Pages: 121-125

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma.2006

    • Author(s)
      Tawara M, Soda H, et al.
    • Journal Title

      Cancer Lett 234(2)

      Pages: 249-255

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effects of macrolides against pneumolysin of macrolide-resistant Streptococcus pneumoniae.2006

    • Author(s)
      Fukuda Y, Tsukamoto K, et al.
    • Journal Title

      Eur Respir J in press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Long-term survial in three patients with metastatic non-small cell lung cancer treated with gefitinib.2006

    • Author(s)
      Nakatomi K, Soda H, Tsukamoto K, et al.
    • Journal Title

      Lung Cancer in press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Tyhmic carcinoma with epidermal growth factor receptor gene mutations.2006

    • Author(s)
      Yamaguchi H, Soda H, Tsukamoto K, et al.
    • Journal Title

      Lung Cancer in press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] BCRP/ABCG2 levels account for the resistance to topoisomerase I inhibitors and reversal effects by gefitinib in non-small cell lung cancer.2006

    • Author(s)
      Nagashima S, Soda H, Tsukamoto K, et al.
    • Journal Title

      Cancer Chemother Pharmacol in press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Visualization of centrosomes by antibodies recognzing phosphorylated ATM at serine 1981 is independent of DNA damage.2006

    • Author(s)
      Suzuki K, Tsukamoto K, et al.
    • Journal Title

      Cell Cycle in press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Phase II study of irinotecan combined with carboplatin in previously untreated small cell lung cancer.2006

    • Author(s)
      Kinoshita A, Soda H, et al.
    • Journal Title

      Brit J Cancer in press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A phase I study of carboplatin and etoposide for elderly (【greater than or equal】75 year-old) patients whth small-cell lung cancer.2006

    • Author(s)
      Fukuda M, Soda H, et al.
    • Journal Title

      Cancer Chemother Pharmacol in press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Impact of p53 aberration on the progression of adult T-cell leukemia/lymphoma.2006

    • Author(s)
      Tawara M, Soda H, et al.
    • Journal Title

      Cancer Lett 234(2)

      Pages: 249-255

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of macrolides against pneumolysin of macrolide-resistant Streptococcus pneumoniae.2006

    • Author(s)
      Fukuda Y, Tsukamoto K, et al.
    • Journal Title

      Eur Respir J (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Long-term survival in three patients with metastatic non-small cell lung cancer treated with gefitinib.2006

    • Author(s)
      Nakatomi K, Soda H, Tsukamoto K, et al.
    • Journal Title

      Lung Cancer (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Thymic carcinoma with epidermal growth factor receptor gene mutations.2006

    • Author(s)
      Yamaguchi H, Soda H, Tsukamoto K, et al.
    • Journal Title

      Lung Cancer (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] BCRP/ABCG2 levels account for the resistance to topoisomerase I inhibitors and reversal effects by gefitinib in non-small cell lung cancer.2006

    • Author(s)
      Nagashima S, Soda H, Tsukamoto K, et al.
    • Journal Title

      Cancer Chemother Pharmacol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Visualization of centrosomes by antibodies recognizing phosphorylated ATM at serine 1981 is independent of DNA damage.2006

    • Author(s)
      Suzuki K, Tsukamoto K, et al.
    • Journal Title

      Cell Cycle (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Phase II study of irinotecan combined with carboplatin in previously untreated small cell lung cancer.2006

    • Author(s)
      Kinoshita A, Soda H, et al.
    • Journal Title

      Brit J Cancer (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A phase I study of carboplatin and etoposide for elderly (【greater than or equal】75 year-old) patients with small-cell lung cancer.2006

    • Author(s)
      Fukuda M, Soda H, et al.
    • Journal Title

      Cancer Chemother Pharmacol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Immunocytochemistry for drugs containing an aliphatic primary amino group in the molecule, anticancer antibiotic daunomycin as a model.2005

    • Author(s)
      Fujiwara K, Tsukamoto K, et al.
    • Journal Title

      J Histochem Cytochem 53(4)

      Pages: 467-474

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Role of Pseudomonas aeruginosa quorum-sensing system in a mouse model of chronic respiratory infection.2005

    • Author(s)
      Imamura Y, Tsukamoto K, et al.
    • Journal Title

      J Med Microbiol 54(Pt6)

      Pages: 515-518

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese.2005

    • Author(s)
      Machida H, Tsukamoto K, et al.
    • Journal Title

      World J Gastroenterol 11(27)

      Pages: 4188-4193

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Crohn's disease in the Japanese is associated with a SNP-haplotype of the N-acetyltransferase 2 gene.2005

    • Author(s)
      Machida H, Tsukamoto K, et al.
    • Journal Title

      World J Gastroenterol 11(31)

      Pages: 4833-4837

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Chronic necrotizing pulmonary aspergillosis following cryptococcal infection of the lung.2005

    • Author(s)
      Kitazaki T, Soda H, et al.
    • Journal Title

      Scand J Infect Dis 37(5)

      Pages: 393-395

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells.2005

    • Author(s)
      Kitazaki T, Soda H, et al.
    • Journal Title

      Lung Cancer 50(1)

      Pages: 19-24

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gefitinib, an EGFR throsine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.2005

    • Author(s)
      Kitazaki T, Soda H, et al.
    • Journal Title

      Lung Cancer 49(3)

      Pages: 337-343

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Novel effects of gefitinib on mucin production in bronchioloalveolar carcinoma; two case reports.2005

    • Author(s)
      Kitazaki T, Soda H, et al.
    • Journal Title

      Lung Cancer 49(1)

      Pages: 125-128

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein /ABCG2-mediated drug resistance.2005

    • Author(s)
      Nakamura Y, Soda H, et al.
    • Journal Title

      Cancer Res 65(4)

      Pages: 1541-1546

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 肺癌術後脳転移に対してGamma-knife stereotactic radiosurgeryを繰り返して長期生存が得られた1例2005

    • Author(s)
      掛屋 弘, 早田 宏, 他
    • Journal Title

      日本呼吸会誌 43(12)

      Pages: 736-740

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 血清可溶性インターロイキン2受容体の上昇を認めた縦隔原発大細胞型B細胞性リンパ種の2例2005

    • Author(s)
      中富克己, 早田 宏, 他
    • Journal Title

      長崎医学会雑誌 80(1)

      Pages: 18-22

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.2005

    • Author(s)
      Kitazaki T, Soda H, et al.
    • Journal Title

      Lung Cancer 49(3)

      Pages: 337-343

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Immunocytochemistry for drugs containing an aliphatic primary amino group in the molecule, anticancer antibiotic daunomycin as a model.2005

    • Author(s)
      Fujiwara K, Takatsu H, Tsukamoto K.
    • Journal Title

      J Histochem Cytochem 53(4)

      Pages: 467-474

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel effects of gefitinib on mucin production in bronchioloalveolar carcinoma ; two case reports.2005

    • Author(s)
      Kitazaki T, Soda H, et al.
    • Journal Title

      Lung Cancer 49(1)

      Pages: 125-128

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.2005

    • Author(s)
      Nakamura Y, Soda H, et al.
    • Journal Title

      Cancer Res 65(4)

      Pages: 1541-1546

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A long-term survival patient with metastatic brain tumor by Gamma-knife stereotactic radiosurgery.[in Japanese]2005

    • Author(s)
      Kakeya H, Soda H, et al.
    • Journal Title

      J Jpn Res Society 43(12)

      Pages: 736-740

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Two patients with mediastinal diffuse large B-cell lymphoma accompanied with elevation of soluble interleukin 2 receptor in sera.[in Japanese]2005

    • Author(s)
      Nakatomi K, Soda H, et al.
    • Journal Title

      Act Med Nagasaki 80(1)

      Pages: 18-22

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Practical POS in health insurance pharmacies.[in Japanese]2005

    • Author(s)
      Tsukamoto K, et al.
    • Journal Title

      Jiho

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Non-small cell lung cancer.[in Japanese]2005

    • Author(s)
      Soda H.
    • Journal Title

      Medical View

      Pages: 240-241

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Carcinomatous pleurisy.[in Japanese]2005

    • Author(s)
      Soda H.
    • Journal Title

      Medical View

      Pages: 238-239

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Lung cancer in the practical side of chemotherapy.[in Japanese]2005

    • Author(s)
      Fukuda M, Soda H, et al.
    • Journal Title

      Nagai Shoten

      Pages: 232-237

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] How to use of molecular target anticancer drugs in lung cancer.[in Japanese]2005

    • Author(s)
      Fukuda M, Soda H, et al.
    • Journal Title

      Tyugai Igakusya

      Pages: 446-457

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ABC transporters.[in Japanese]2005

    • Author(s)
      Oka M, Soda H, et al.
    • Journal Title

      Tyugai Igakusya

      Pages: 68-74

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Pulmonary sound analysis by electronic stethoscope.[in Japanese]2005

    • Author(s)
      Miyahara S, Soda H, et al.
    • Journal Title

      Clin Pharmacol 15(5)

      Pages: 511-518

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Anticancer drugs and ABC transporters.[in Japanese]2005

    • Author(s)
      Oka M, Soda H, et al.
    • Journal Title

      Jpn J Cancer Chemother 32(5)

      Pages: 585-592

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Outpatient chemotherapy in lung cancers.[in Japanese}2005

    • Author(s)
      Yamaguchi H, Soda H, et al.
    • Journal Title

      Adult-onset diseases & Lifestyle-related illness 35(3)

      Pages: 304-309

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chemotherapy for non-small cell lung cancer.[in Japanese]2005

    • Author(s)
      Fukuda M, Soda H, et al.
    • Journal Title

      Mebio 22(1)

      Pages: 44-53

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] LRPS, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density.2004

    • Author(s)
      Mizuguchi T, Tsukamoto K, et al.
    • Journal Title

      J Hum Genet 49(2)

      Pages: 80-86

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Pharmacodynamics and bactericidal activity of gatifloxacin in experimental pneumonia caused by penicillin-resistant Streptococcus pneumoniae.2004

    • Author(s)
      Yanagihara K, Tsukamoto K, et al.
    • Journal Title

      Chemotherapy 50(3)

      Pages: 107-112

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family.2004

    • Author(s)
      Okubo A, Tsukamoto K, et al.
    • Journal Title

      J Med Genet 41

      Pages: e97

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-oxododecanoyl) homoserine lactone in NCI-H292 cells.2004

    • Author(s)
      Imamura Y, Tsukamoto K, et al.
    • Journal Title

      Antimicrob Agents Chemother 48(9)

      Pages: 3457-3461

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Efficacy of quinupristin/dalfopristin against methicillin-resistant Staphylococcus aureus and vancomycin-insensitive S. aureus in a model of hematogenous pulmonary infection.2004

    • Author(s)
      Yanagihara K, Tsukamoto K, et al.
    • Journal Title

      Chemotherapy 50(5)

      Pages: 260-264

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells.2004

    • Author(s)
      Doi S, Soda H, et al.
    • Journal Title

      Mol Cancer Ther 3(11)

      Pages: 1397-1402

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Reversal of breast cancer resistance protein (BCRP/ABCG2)-mediated drug resistance by novobiocin, a coumermycin antibiotic.2004

    • Author(s)
      Shiozawa K, Soda H, et al.
    • Journal Title

      Int J Cancer 108(1)

      Pages: 146-151

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells.2004

    • Author(s)
      Yoshikawa M, Soda H, et al.
    • Journal Title

      Int J Cancer 110(6)

      Pages: 921-927

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Phase II study of irinotecan combined with carboplatin in previously untreated non-small-cell lung cancer.2004

    • Author(s)
      Fukuda M, Soda H, et al.
    • Journal Title

      Cancer Chemother Pharmacol 54(6)

      Pages: 573-577

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] High-risk populations for nasal carriage of methicillin-resistant Staphylococcus aureus.2004

    • Author(s)
      Fukuda M, Soda H, et al.
    • Journal Title

      J Infect Chemother 10(3)

      Pages: 189-191

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Clinical relevance of survivin as a biomarker in neoplasms, especially in adult T-cell leukemias and acute leukemias.2004

    • Author(s)
      Sugahara K, Soda H, et al.
    • Journal Title

      Int J Hematol 80(1)

      Pages: 52-58

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Autoimmunity to heat shock protein 40 in ulcerative colitis.2004

    • Author(s)
      Sato S, Soda H, et al.
    • Journal Title

      J Int Med Res 32(2)

      Pages: 141-148

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] LRP5, low-density-lipoprotein receptor-related protein 5, is a determinant for bone mineral density.2004

    • Author(s)
      Mizuguchi T, Tsukamoto K, et al.
    • Journal Title

      J Hum Genet 49(2)

      Pages: 80-86

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Efficacy of quinupristin/dalfopristin against methicillin-resistant Staphylococcus aureus and vancomycin-insensitive S.aureus in a model of hematogenous pulmonary infection.2004

    • Author(s)
      Yanagihara K, Tsukamoto K, et al.
    • Journal Title

      Chemotherapy 50(5)

      Pages: 260-264

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The histone deacetylase inhibitor FR901128 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells.2004

    • Author(s)
      Doi S, Soda H, et al.
    • Journal Title

      Mol Cancer Ther 3(11)

      Pages: 1397-1402

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Tietz syndrome.[in Japanese]2004

    • Author(s)
      Tsukamoto K, Kohno S.
    • Journal Title

      Syndromes in Dermatology (Nakayama shoten)

      Pages: 346-347

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Opportunistic pneumoniae and parasitic lung diseases.[in Japanese]2004

    • Author(s)
      Soda H, et al.
    • Journal Title

      Diagnosis and Treatment 92(4)

      Pages: 595-602

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Risk factors of gefitinib-induced lung injuries.[in Japanese]2004

    • Author(s)
      Kawabata S, Soda H, et al.
    • Journal Title

      THE LUNG-perspectives 12(2)

      Pages: 195-200

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Influenza and common cold.[in Japanese]2004

    • Author(s)
      Yamamoto K, Soda H, et al.
    • Journal Title

      Obstet Gynecol 71

      Pages: 1425-1431

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] An availability of the measurement of intact PTH on enucleation of parathyroid glands.[in Japanese]2004

    • Author(s)
      Ishibashi M, Soda H, et al.
    • Journal Title

      Medical examination 53

      Pages: 1355-1359

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A senior case with thrombotic thrombocytopenic purpura followed by bilateral diffuse infiltration shadow.[in Japanese]2004

    • Author(s)
      Kasai N, Soda H, et al.
    • Journal Title

      Jpn J Chest Dis 63(5)

      Pages: 488-494

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 保険薬局におけるPOSの実際2005

    • Author(s)
      塚元和弘, 松田賢治
    • Total Pages
      265
    • Publisher
      じほう
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 疾患別最新処方 肺非小細胞癌2005

    • Author(s)
      早田 宏
    • Total Pages
      240-241
    • Publisher
      メジカルビュー社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 疾患別最新処方 癌性胸膜炎2005

    • Author(s)
      早田 宏
    • Total Pages
      238-239
    • Publisher
      メジカルビュー社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 臨床腫瘍内科学入門 化学療法の実際 肺癌2005

    • Author(s)
      福田 実, 早田 宏, 他
    • Total Pages
      232-237
    • Publisher
      永井書店
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] EBM呼吸器疾患の治療2006-2007 肺癌 分子標的薬の使い方は?2005

    • Author(s)
      福田 実, 早田 宏, 他
    • Total Pages
      446-457
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 癌科学療法update ABCトランスポーター2005

    • Author(s)
      岡 三喜男, 早田 宏, 他
    • Total Pages
      68-74
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 電子聴診器による肺音の解析2005

    • Author(s)
      宮原末治, 早田 宏, 他
    • Total Pages
      511-5518
    • Publisher
      薬理と臨床15(5)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 抗がん剤とABCトランスポーター2005

    • Author(s)
      岡 三喜男, 早田 宏, 他
    • Total Pages
      585-592
    • Publisher
      癌と化学療法32(5)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 肺癌の外来科学療法2005

    • Author(s)
      山口博之, 早田 宏, 他
    • Total Pages
      304-309
    • Publisher
      成人病と生活習慣病35(3)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 診断と治療の最前線 : 化学療法 非小細胞肺癌2005

    • Author(s)
      福田 実, 早田 宏, 他
    • Total Pages
      44-53
    • Publisher
      Mebio 22(1)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 最新皮膚科学大系特別巻2 -皮膚科症候群- 「Titzi症候群」2004

    • Author(s)
      塚元和弘, 河野 茂
    • Total Pages
      346-347
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 呼吸器疾患の胸部単純X線写真 : 易感染性宿主の肺炎と肺真菌症・寄生虫性肺疾患2004

    • Author(s)
      早田 宏, 他
    • Total Pages
      595-602
    • Publisher
      診断と治療92(4)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 基礎医学とのダイアローグ : ゲフィチニブ投与後の肺障害の発生リスク因子2004

    • Author(s)
      川畑 茂, 早田 宏, 他
    • Total Pages
      195-200
    • Publisher
      THE LUNG-perspectives12(2)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] インフルエンザ・かぜ症候群2004

    • Author(s)
      山本和子, 早田 宏, 他
    • Total Pages
      1425-1431
    • Publisher
      産科と婦人科71
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 副甲状腺摘出術における術中迅速intact PTH測定の有用性2004

    • Author(s)
      石橋純美, 早田 宏, 他
    • Total Pages
      1355-1359
    • Publisher
      医学検査53
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 両側肺のびまん性浸潤影に続いて発祥した高齢者の血栓性血小板減少性紫斑病の1例2004

    • Author(s)
      笠井 尚, 早田 宏, 他
    • Total Pages
      488-494
    • Publisher
      日本胸部臨床63(5)
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2007-12-13  

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