2005 Fiscal Year Final Research Report Summary
Plasma Endothelin-1 (ET-1) is a useful marker for early renal dysfunction in a general population
| Project/Area Number |
16590526
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
HIRAI Yuji Kurume University, The Third Department of Internal Medicine, Research Associate, 医学部, 助手 (70309780)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ADACHI Hisashi Kurume University, The Third Department of Internal Medicine, Associate Professor, 医学部, 助教授 (40212518)
ENOMOTO Mika Kurume University, The Third Department of Internal Medicine, Associate Professor, 医学部, 助手 (10360281)
|
|---|
| Project Period (FY) |
2004 – 2005
|
| Keywords | Health check-up / Endothelin-1 / Blood pressure / Organ damage / Vasoconstrictor / Epidemiology |
|---|
| Research Abstract |
Endothelin-1 (ET-1) is a potent vasoconstrictor derived from the endothelium. Several studies with a small number in humans showed high plasma ET-1 levels in hypertension but did not so in other studies. Furthermore, it has been shown in a small number of subjects that ET-1 is elevated in uremic patients. However, there have been no epidemiological surveys as to whether ET-1 level is related to renal dysfunction. A total of 1,492 subjects received a health examination in 1999. The data for fasting ET-1 of 1,450 were obtained. A specific radioimmunoassay was used to measure ET-1 levels. We also measured BMI, systolic and diastolic blood pressure (BP), hemoglobin A_<1c>, cholesterol, BUN, creatinine, and uric acid. Creatinine clearance was calculated by the Cockcroft-Gault formula for assessing kidney function : [(140-age)×weight(kg)]/[72×serum creatinine](×0.85 for women). Smoking habit was evaluated by questionnaire. Mean ET-1 was 4.93±1.73pg/ml in men and 4.84±1.54pg/ml in women. Mean glomerular filtration rate (GFR) was 69.9±20.7ml/min in men and 65.3±18.6ml/min in women. ET-1 showed a strong inverse association (p<0.001) with GFR. After controlling for age, which is the strongest relation to ET-1, the association remained significant. In order to further examine the association between plasma ET-1 levels and GFR, we performed analysis of covariance. The mean ET-1 stratified by quintiles of GFR adjusted for age, sex and smoking, which is significantly associated with ET-1. There was a linear and significant inversely trend (p=0.03) between ET-1 and GFR. Our data suggest that elevated ET-1 is a useful marker for renal dysfunction in an epidemiological study.
|
