2005 Fiscal Year Final Research Report Summary
Effect of Kampo medicine on cognition and behavior of Alzheimer's disease patinas.
| Project/Area Number |
16590554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
ARAI Hiroyuki Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (30261613)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Alzheimer's disease / cognitive function / complementary and alternative medicine / Dementia with Lewy bodies / Kampo medicine / Integrated medicine / Donepezil / cerebral blood flow |
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| Research Abstract |
In this study, we showed 3 major findings (evidenced based medicine) regarding complementary and alternative medicine of Kampo medicine
1.A combinatorial use of donepezil and kami-untan-to(Japanese herbal medicine) was found to be more beneficial than each drug alone. An increase in cerebral blood flow also was observed only in the patients who received both donepezil and kami-untan-to. These results may provide a new evidence for integrated medicine of Western/complementary and alternative medicine.
2.A randomized, placebo-controlled, double blind clinical trial showed that 8 week treatment by Ba-wei-di-huang wan, a traditional Chinese medicine, wan was found to improve not only cognitive function, but also physical activity in Alzheimer's patients. No serious adverse events were found following use of Ba-wei-di-huang.
3.No reliable therapy was known to be beneficial in dementia with Lewy bodies. A observer-blind controlled study showed that Yi-Gan-San, a traditional Chinese medicine, was found to be beneficial in reducing severity and frequency of behavioral and psychological symptoms of dementia such as visual hallucination, delusion and emotional irritability. Notably, it is most notable that visual hallucination associated with dementia with Lewy bodies declined dramatically without producing neuroleptic supersensitivity. Yi-Gan-San improve not only cognitive functions.
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[Journal Article] Uncaria rhynchophylla, a Chinese medicinal herb, has potent anti-aggregation effects on Alzheimer's amyloid beta proteins2006
Author(s)
Fujiwara H, Iwasaki K, Furukawa K, Seki T, Mei H, Maruyama, M, Tomita N, Kudo Y, Higuchi M, Saido T, Maeda S, Takashima A, Hara Masahiko, Ohizumi Y, Arai H.
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Journal Title
J. Neurosci. Res. (In Press.)
Description
「研究成果報告書概要(和文)」より
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[Journal Article] A Randomized Observer-Blind Controlled Trial of a Traditional Chinise Mdeicine, Yi-Gan San, on Behaviroral and Psychological Symptoms and Activities of Daily Living in Dementia Patiensta.2006
Author(s)
Iwasaki K, Sato-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H.
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Journal Title
J.Clin.Psyciaty. 66
Pages: 248-252
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A Randomized Observer-Blind Controlled Trial of a Traditional Chinise Mdeicine, Yi-Gan San, on Behaviroral and Psychological Symptoms and Activities of Daily Living in Dementia Patiensta.2005
Author(s)
Iwasaki K, Sato-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H.
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Journal Title
J. Clin. Psychiatry. 66
Pages: 248-252
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Uncaria rhynchophylla, a Chinese medicinal herb, has potent anti-aggregation effects on Alzheimer's amyloid beta proteins
Author(s)
Fujiwara H, Iwasaki K, Furukawa K, Seki T, Mei H, Maruyama, M, Tomita N, Kudo Y, Higuchi M, Saido T, Maeda S, Takashima A, Hara Masahiko, Ohizumi Y, Arai H.
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Journal Title
J.Neurosci.Res. (in press)
Description
「研究成果報告書概要(欧文)」より
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