• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Study of mechanism of gastric carcinogenesis associated with EBV-mediated IGF-1 induction

Research Project

Project/Area Number 16590566
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHokkaido University

Principal Investigator

IWAKIRI Dai  Hokkaido University, Institute for genetic medicine, lecturer, 遺伝子病制御研究所, 助手 (10307853)

Project Period (FY) 2004 – 2005
KeywordsEBV / gastric cancer / nasopharyngeal carcinoma / EBER / IGF-1 / RIG-I
Research Abstract

We have previously reported that EBV infection of gastric epithelial cells leads to induction of insulin-like growth factor (IGF)-1 and IGF-1 promotes growth of EBV-infected cells by an autocrine mechanism. We have also identified that EBV-encoded small RNA (EBER) is the responsible gene for IGF-1 induction. In this study, we demonstrated that EBV promotes growth of nasopharyngeal epithelial cells thorough induction of IGF-1 by EBER. Furthermore, we observed high IGF-1 expression in nasopharyngeal carcinoma (NPC) tissues. These findings strongly suggest that EBER plays a significant role in epithelial cancer development. We also tried to assess the mechanism of EBER-mediated IGF-1 induction and identified that EBER induces intracellular signaling through interaction with retinoic acid-inducible gene (RIG)-I (Submitted). Since RIG-I has RNA-helicase domain and Caspase activation and recruiting domain (CARD), it recognizes dsRNA and induces production of interferon and other cytokines through activation of IRF-3 or NF-κB. Our results suggest that EBER-RIG-I interaction induces growth factor expression in EBV-infected cells, and further study is going on.

  • Research Products

    (4 results)

All 2005

All Journal Article (2 results) Book (2 results)

  • [Journal Article] Epstein-Barr virus-encoded small RNA induces insulin-like growth factor and supports growth of nasopharyngeal carcinoma-derived cell lines2005

    • Author(s)
      Iwakiri D. et al.
    • Journal Title

      Oncogene 24

      Pages: 1767-1773

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Epstein-Barr virus-encoded small RNA induces insulin-like growth factor and supports growth of nasopharyngeal carcinoma-derived cell lines2005

    • Author(s)
      Iwakiri D., et al.
    • Journal Title

      Oncogene 24

      Pages: 1767-1773

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Epstein-Barr Virus(E. S. Robertson Ed)2005

    • Author(s)
      Iwakiri D., Takada K.
    • Total Pages
      13
    • Publisher
      Caister Academic Press
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Epstein-Barr Virus and Gastric Cancers(E.S.Robertson Ed)2005

    • Author(s)
      Iwakiri D., Takada K.
    • Publisher
      Epstein-Barr Virus Caister Academic Press
    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi