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2005 Fiscal Year Final Research Report Summary

Identification of novel stromal factors that regulate β-catenin localization in colorectal cancer --Prevention of invasion and metastasis in colorectal cancer--

Research Project

Project/Area Number 16590589
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKINKI UNIVERSITY (2005)
Kyoto University (2004)

Principal Investigator

NABESHIMA Motoshige  KINKI UNIVERSITY, Hospital, Associate professor, 医学部附属病院, 助教授 (80314178)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO Shinichi  Kyoto University, Department of Gastroenterology and Hepatology, Assistant professor, 医学研究科, 助手 (90378761)
Project Period (FY) 2004 – 2005
Keywordscolon / β-catenin / inflammation / tumorigenesis / stroma / IL-6 / Gas6 / cytokine
Research Abstract

To investigate the role of stromal factors during colorectal tumorigenesis, we determined the factors highly expressed in cancer stroma using laser capture microdissection system and DNA arrays. Among those factors, we analyzed the effects of IL-6, COX-2 and Gas6 in this study.
First, in SW480 cells we observed translocation of β-catenin from the nucleus to the cytoplasm by inhibition of STAT3 which transmits IL-6 signaling. Second, by using co-culture system we demonstrated that local hypoxia up-regulated COX-2 expression in tumor stromal cells. Third, we found that Gas6 activated PI3K/Akt pathway in DLD-1 cells with suppression of cellular apoptosis.
These data suggest a strong association between stromal factors and cancer cell behaviors, and may lead us to novel therapeutic strategies.

  • Research Products

    (12 results)

All 2006 2005 2004

All Journal Article (12 results)

  • [Journal Article] STAT3 activation is involved in nuclear accumulation of b-catenin in colorectal cancer.2006

    • Author(s)
      Kawada M, Seno H, Chiba T, et al.
    • Journal Title

      Cancer Res (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Hypoxia induced by intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1 dependent pathway.2006

    • Author(s)
      Uenoyama Y, Seno H, Chiba T, et al.
    • Journal Title

      Oncogene (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] STAT3 activation is involved in nuclear accumulation of b-catenin in colorectal cancer.2006

    • Author(s)
      Kawada M, Seno H, Uenoyama Y, Sawabu T, Kanda N, Fukui H, Shimahara T, Chiba T
    • Journal Title

      Cancer Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hypoxia induced by intestinal epithelial, cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1 dependent pathway.2006

    • Author(s)
      Uenoyama Y, Seno H, Fukuda A, Sekikawa A, Nanakin A, Sawabu T, Kawada M, Kanda N, Suzuki K, Yada N, Fukui H, Chiba T
    • Journal Title

      Oncogene (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Possible role of REG Iα protein in ulcerative colitis and colitic cancer.2005

    • Author(s)
      Sekikawa A, Fukui H, Chiba T, et al.
    • Journal Title

      Gut 54

      Pages: 1437-1444

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] REG Iα protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.2005

    • Author(s)
      Sekikawa A, Fukui H, Chiba T, et al.
    • Journal Title

      Gastroenterology 128

      Pages: 642-653

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine.2005

    • Author(s)
      Suzuki K, Fukui H, Chiba T, et al.
    • Journal Title

      Biochem Biophys Res Commun 328

      Pages: 348-352

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Possible role of REG I{alpha} protein in ulcerative colitis and colitic cancer.2005

    • Author(s)
      Sekikawa A, Fukui H, Fujii S, Nanakin A, Kanda N, Uenoyama Y, Sawabu T, Hisatsune H, Kusaka T, Ueno S, Nakase H, Seno H, Fujimori T, Chiba T
    • Journal Title

      Gut 54

      Pages: 1437-1444

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.2005

    • Author(s)
      Sekikawa A, Fukui H, Fujii S, Takeda J, Nanakin A, Hisatsune H, Seno H, Takasawa S, Okamoto H, Fujimori T, Chiba T
    • Journal Title

      Gastroenterology 128

      Pages: 642-653

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine.2005

    • Author(s)
      Suzuki K, Fukui H, Kayahara T, Sawada M, Seno H, Hiai H, Kageyama R, Okano H, Chiba T
    • Journal Title

      Biochem Biophys Res Commun. 328

      Pages: 348-352

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.2004

    • Author(s)
      Kanda N, Seno H, Chiba T, et al.
    • Journal Title

      Oncogene 23

      Pages: 4921-4929

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.2004

    • Author(s)
      Kanda N, Seno H, Konda Y, Kanai M, Nakajima T, Kawashima T, Nanakin A, Sawabu T, Uenoyama Y, Sekikawa A, Kawada M, Suzuki K, Kayahara T, Fukui H, Sawada M, Marusawa H, Chiba T
    • Journal Title

      Oncogene 23

      Pages: 4921-4929

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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