2005 Fiscal Year Final Research Report Summary
Basic analysis for developing a novel cancer treatment utilizing mutant p53 modifier CP-31398
| Project/Area Number |
16590610
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | SAPPORO MEDICAL UNIVERSITY |
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Principal Investigator |
TAKIMOTO Rishu SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE, FOURTH DEPARTMENT OF INTERNAL MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (10336399)
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| Project Period (FY) |
2004 – 2005
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| Keywords | P53 / CANCER TREATMENT / CP31398 |
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| Research Abstract |
It has been shown that tumor suppressor gene, p53, is mutated in various gastrointestinal (GI) cancers. Loss of function of p53 exerts tumor development and progression, therefore restoration of p53 function might be useful for cancer treatment. CP31398 has developed for restoration of mutated p53 by modifying DNA-binding domain where frequently observed mutation in various cancers. We utilized CP31398 for a novel strategy for cancer treatment combined with modified (activated) p53. We tested mutant p53 and wild-type p53 expressing GI cancer cell lines with CP31398 with or without modified p53 transduction. As a result, CP31398 could enhance the cytotoxicity of modified p53 in SW480 cells possibly by induction of proapoptotic gene in a p53-dependent manner. This novel strategy will be a promising approach for GI cancer treatment.
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[Journal Article] Related Involvement of transforming growth factor-beta and thrombopoietin in the pathogenesis of myelodysplastic syndrome with myelofibrosis.2005
Author(s)
Akiyama T, Matsunaga T, Terui T, Miyanishi K, Tanaka I, Sato T, Kuroda H, Takimoto R, Takayama T, Kato J, Yamauchi N, Kogawa K, Sakamaki S, Hirayama Y, Kohda K, Niitsu Y.
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Journal Title
Leukemia. 19
Pages: 1558-1566
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A patient with TP53 germline mutation developed Bowen's disease and myelodysplastic syndrome with myelofibrosis after chemotherapy against ovarian cancer.2005
Author(s)
Kuribayashi K, Matsunaga T, Sakai T, Wada Y, Tateno K, Murase K, Fujimi A, Takimoto R, Terui T, Kato J, Sasaki A, Satoh M, Niitsu Y.
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Journal Title
Intern Med. 44
Pages: 490-495
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor.2005
Author(s)
Takimoto R, Kato J, Terui T, Takada K, Kuroiwa G, Wu J, Ohnuma H, Takahari D, Kobune M, Sato Y, Takayama T, Matsunaga T, Niitsu Y.
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Journal Title
Cancer Biol Ther. 4
Pages: 421-428
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.2005
Author(s)
Sato Y, Araki H, Kato J, Nakamura K, Kawano Y, Kobune M, Sato T, Miyanishi K, Takayama T, Takahashi M, Takimoto R, Iyama S, Matsunaga T, Ohtani S, Matsuura A, Hamada H, Niitsu Y.
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Journal Title
Blood. 106
Pages: 756-763
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Decrease of Smad4 gene expression in patients with essential thrombocythaemia may cause an escape from suppression of megakaryopoiesis by transforming growth factor-beta1.2004
Author(s)
Kuroda H, Matsunaga T, Terui T, Tanaka I, Takimoto R, Fujikawa K, Takayama T, Kato J, Hirayama Y, Sakarnaki S, Kohda K, Niitsu Y.
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Journal Title
Br J Haematol. 124
Pages: 211-220
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-beta2m-/- repopulating cells.2004
Author(s)
Kobune M, Ito Y, Kawano Y, Sasaki K, Uchida H, Nakamura K, Dehari H, Chiba H, Takimoto R, Matsunaga T, Terui T, Kato J, Niitsu Y, Hamada H.
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Journal Title
Blood. 104
Pages: 1002-1009
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells.2004
Author(s)
Sato T, Machida T, Takahashi S, Iyama S, Sato Y, Kuribayashi K, Takada K, Oku T, Kawano Y, Okamoto T, Takimoto R, Matsunaga T, Takayama T, Takahashi M, Kato J, Niitsu Y.
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Journal Title
J Immunol. 173
Pages: 285-296
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Ethanol induces transforming growth factor-alpha expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells.2003
Author(s)
Kato J, Sato Y, Inui N, Nakano Y, Takimoto R, Takada K, Kobune M, Kuroiwa G, Miyake S, Kohgo Y, Niitsu Y.
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Journal Title
Alcohol Clin Exp Res. 8 Suppl
Pages: 58S-63S
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells.2003
Author(s)
Kobune M, Kawano Y, Ito Y, Chiba H, Nakamura K, Tsuda H, Sasaki K, Dehari H, Uchida H, Honmou O, Takahashi S, Bizen A, Takimoto R, Matsunaga T, Kato J, Kato K, Houkin K, Niitsu Y, Hamada H.
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Journal Title
Exp Hematol. 31
Pages: 715-722
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Induction of PIGS and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors.2003
Author(s)
Terui T, Murakami K, Takimoto R, Takahashi M, Takada K, Murakami T, Minami S, Matsunaga T, Takayama T, Kato J, Niitsu Y.
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Journal Title
Cancer Res. 63
Pages: 8948-8954
Description
「研究成果報告書概要(欧文)」より
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