2005 Fiscal Year Final Research Report Summary
Regulation of Inflammatory Cardiovascular Diseases
| Project/Area Number |
16590663
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
SUZUKI Jun-ichi Tokyo Medical and Dental University, Department of Cardiovascular Medicine, Junior Lecturer, 医学部附属病院, 助手 (90313858)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISOBE Mitsuaki Tokyo Medical and Dental University, Department of Cardiovascular Medicine, Professor, 大学院・医歯学総合研究科, 教授 (80176263)
AMANO Jun Shinshu University, Department of Surgery, Professor, 医学部, 教授 (20138283)
|
|---|
| Project Period (FY) |
2004 – 2005
|
| Keywords | inflammation / myocardial ischemia / myocarditis / transplant rejection / restenosis / gene therapy / remodeling / clinical trial |
|---|
| Research Abstract |
Background. Inflammation is a central event in cardiovascular diseases such as myocardial infarction, myocarditis, transplant rejection and arteriosclerosis after angioplasty. Methods and Results. To evaluate the effectiveness of blocking inflammation to prevent these diseases, we made several murine and rat experimental models. We showed that each treatment using a COX-2 inhibitor, pioglitazone, or tea catechins prevented acute and chronic cardiac rejection. We also demonstrated that treatment with a statin, a CCR1 antagonist, or a COX-2 inhibitor suppressed the rat autoimmune myocarditis. A specific I-kB inhibitor significantly suppressed ventricular remodeling after myocardial ischemia. An NF-kB decoy, an anti-E-selectin antibody, or an anti-VCAM-1 antibody suppressed arterial neointimal formation after arterial injury in a murine model. Based on these results, we performed clinical trials to prevent restenosis after PCI. Conclusion. Inflammation plays a pivotal role in cardiovascular diseases. These results suggest the clinical usefulness of gene therapies to regulate inflammatory cardiovascular diseases.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] The blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allografts.2004
Author(s)
Koga N, Suzuki J, Kosuge H, Haraguchi G, Onai Y, Futamatsu H, Maejima Y, Gotoh R, Saiki H, Tsushima F, Azuma M, Isobe M.
-
Journal Title
Arterioscler Thromb Vasc Biol. 24
Pages: 2057-2062
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Journal Article] Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation : Induction of tolerance and prevention of cardiac allograft vasculopathy.2004
Author(s)
Yamaura K, Ito K, Tsukioka K, Wada Y, Makiuchi A, Sakaguchi M, Akashima T, Fujimori M, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Suzuki J, Amano J, Isobe M.
-
Journal Title
Circulation. 110
Pages: 1650-1657
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
[Journal Article] Utility of gallium-67 scintigraphy for evaluation of cardiac sarcoidosis with ventricular tachycardia.
Author(s)
Futamatsu H, Suzuki J, Adachi S, Okada H, Otomo K, Ohara T, Hashimoto Y, Kakuta T, Iesaka Y, Yamaguchi H, Sakurada H, Sato A, Obayashi T, Niwa A, Hirao K, Isobe M.
-
Journal Title
Int J Cardiovas Imag. (In press)
Description
「研究成果報告書概要(欧文)」より
