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2006 Fiscal Year Final Research Report Summary

Brain function during dyspnea sensation

Research Project

Project/Area Number 16590731
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

HIDA Wataru  Tohoku University, Center for the advancement of higher education, Professor, 高等教育開発推進センター, 教授 (10142944)

Co-Investigator(Kenkyū-buntansha) ITOH Masatoshi  Cyclotron and Radioisotope Center, Professor, サイクロトロン・ラジオアイソトープセンター, 教授 (00125501)
KUROSAWA Hajime  Tohoku University, Center for the advancement of higher education, Associate Professor, 高等教育開発推進センター, 助教授 (60333788)
OGAWA Hiromasa  Tohoku University, Center for the advancement of higher education, Associate Professor, 高等教育開発推進センター, 助教授 (90361162)
KUROSAWA Hajime  Tohoku University, Center for the advancement of higher education, Associate Professor (60333788)
Project Period (FY) 2004 – 2006
Keywordschronic obstructive pulmonary disease / dyspnea / inspiratory resistance / positron emission tomography / brain metabolism
Research Abstract

The early symptom of chronic obstructive pulmonary disease (COPD) is dyspnea during exercise, and severe COPD has dyspnea even while quiet breathing. Dyspnea is perceived in the brain. However, brain function during dyspnea has not been unknown. The aim of this study was to examine the brain function during dyspnea. We examined brain function during resistive inspiratory loaded breathing in healthy subjects and during quiet breathing in severe COPD patients, by using a brain imaging technique, positron emission tomography (PET) and statistical parametric mapping. PET studies were performed by injecting of fluorine 18 (18F)-labeled fluorodeoxyglucose (FDG) during resting breathing in normal control group and after applying the inspiratory resistance in another normal group. PET studies in severe COPD patients were only during resting breathing.
We observed the activation sites and deactivation sites in the brain as follows.
1)Dyspnea increased with increase in resistive loading in normal group. In normal group with resistive loaded breathing. The sites of precentral gyrus, postcentral gyrus, and orbital gyrus were activated, and the sites of precuneus, middle frontal gyrus, superior parietal lobe and cingulate gyrus were deactivated.
2)In severe COPD patients, the sites of lingual gyrus, superior temporal gyrus, and orbital gyms were activated, and the sites of precuneus, cingulate gyrus, temporal lobe, superior parietal lobe and inferior parietal lobe were deactivated.
3)Orbital gyrus was activated in both normal and COPD groups, and precuneus, cingulate gyms and superior parietal lobe were deactivated in both groups. The physiological meaning of the activation and deactivation in the brain observed in this study has not been clarified.

  • Research Products

    (12 results)

All 2006 2005 2004

All Journal Article (12 results)

  • [Journal Article] Mice with blunted hypoxic ventilatory response are susceptible to respiratory distubance during hypoxia2006

    • Author(s)
      Adachi T
    • Journal Title

      Tohoku J Exp Med 209・2

      Pages: 125-134

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Morphologic analysis of mandible and upper airway soft tissue by MRI of patients with obstructive sleep apnea hypopnea syndrome2006

    • Author(s)
      Okubo M
    • Journal Title

      SLEEP 29・7

      Pages: 909-915

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Clinical characteristics of obesity-hypoventilation syndrome in Japan : a multi-center study2006

    • Author(s)
      Akashiba T
    • Journal Title

      Internal Medicine 45

      Pages: 1121-1125

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Mice with blunted hypoxic ventilatory response are susceptible to respiratory distubance during hypoxia.2006

    • Author(s)
      Adachi T
    • Journal Title

      Tohoku J Exp Med 209(2)

      Pages: 125-134

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Morphologic analysis of mandible and upper airway soft tissue by MRI of patients with obstructive sleep apnea hypopnea syndrome.2006

    • Author(s)
      Okubo M
    • Journal Title

      SLEEP 29(7)

      Pages: 909-915

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clinical characteristics of obesity-hypoventilation syndrome in Japan : a multi-center study.2006

    • Author(s)
      Akashiba T
    • Journal Title

      Internal Medicine 45

      Pages: 1121-1125

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prevalence of chronic obstructive pulmonary disease in Japanese people on medical check-up2005

    • Author(s)
      Takemura H
    • Journal Title

      Tohoku J Exp Med 207

      Pages: 41-50

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prevalence of chronic obstructive pulmonary disease in Japanese people on medical check-up.2005

    • Author(s)
      Takemura H
    • Journal Title

      Tohoku J Exp Med 207(1)

      Pages: 41-50

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Improved activities of daily living, psychological state and health-related quality of life for 12 months following lung volume reduction surgery in patients with severe emphysema2004

    • Author(s)
      Goto Y
    • Journal Title

      Respiration 9

      Pages: 337-344

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dynamic airway narrowing2004

    • Author(s)
      Kurosawa H
    • Journal Title

      N Engl J Med 350

      Pages: 1036

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Improved activities of daily living, psychological state and health-related quality of life for 12 months following lung volume reduction surgery in patients with severe emphysema.2004

    • Author(s)
      Goto Y
    • Journal Title

      Respiration 9

      Pages: 337-344

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dynamic airway narrowing.2004

    • Author(s)
      Kurosawa H
    • Journal Title

      N Engl J Med 350

      Pages: 1036

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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