2005 Fiscal Year Final Research Report Summary
To clarify the mechanism of Th1 suppression to protect renal function by angiotensin II receptor blocker
| Project/Area Number |
16591010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IGARASHI Takashi The University of Tokyo, Faculty of Medicine, Professor, 医学部附属病院, 教授 (70151256)
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| Co-Investigator(Kenkyū-buntansha) |
SEKINE Takashi The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (50255402)
INATOMI Jun The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (00311960)
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| Project Period (FY) |
2004 – 2005
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| Keywords | angiotensin type II receptor blocker / Th1 action / renoprotective medicine |
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| Research Abstract |
The change of Th1/Th2 balance is critical for the development of renal damage in various kind of chronic nephritis. Predominant Th1 activity is often seen in the patients and model mice with active stage of systemic lupus erythematosus (SLE). We gave angiotensin type II receptor blocker, olmesartan, 10mg/kg/day to MRL/lps (spontaneously manifesting lupus) mice (n = 10) aged 9 weeks for 19 weeks. Then, we checked Interferon-γ (INF-γ) and interleukin-4 (IL-4) levels in the supernatant of the cultured T cells from the spleen in mice MRL/lps mice with or without olmesartan administration. This revealed that there was no difference in INF-γ and IL-4 levels in the supernatants between the two groups. However, MRL/lps mice to which olmesartan was administered lived longer, than the MRL/lps mice to which olmesartan was not administered. Although olmesartan do not suppress the Th1 activity in MRL/lps mice, it may have a beneficial effect on various organs such as heart. This beneficial effect may elongate the life span of MRL/lps mice.
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[Journal Article] A familial case of multicystic dysplastic kidney.2005
Author(s)
Sekine T, Namai Y, Yanagisawa A, Shirahama H, Tashiro Y, Terahara M, Nagata M, Harita Y, Fukuoka U, Inatomi J, Igarashi T
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Journal Title
Pediatr Nephrol 20
Pages: 1245-1248
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Functional analysis of NBC1 mutants associated with proximal tubular acidosis and ocular abnormalities.2005
Author(s)
Horita S, Yamada H, Inatomi J, Moriyama N, Sekine T, Igarashi T, Endo Y, Dasouki M, Ekim M, Al-Gazali L, Shimada M, Seki G, Fujita T
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Journal Title
J Am Soc Nephrol 16
Pages: 2270-2278
Description
「研究成果報告書概要(欧文)」より
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