2007 Fiscal Year Final Research Report Summary
Residual hemopoiesis and myelodysplasia development in aplastic anemia children. -Epidemiologic and clinical observation
| Project/Area Number |
16591058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Toho University |
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Principal Investigator |
OHARA Akira Toho University, Faculty of Medicine, Professor (00142498)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUYAMA Mika Toho University, Faculty of Medicine, Teaching assistant (50339173)
KOJIMA Yasuko Toho University, Faculty of Medicine, Teaching assistant (80408781)
MITSUI Kazumasa Toho University, Faculty of Medicine, Thaching assistant (80349919)
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| Project Period (FY) |
2004 – 2007
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| Keywords | bone marrow failure / aplastic anemia / myelodyndastic syndrome |
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| Research Abstract |
Although both of an aplastic anemia (AA) and a myelodysplastic syndrome(MDS)-refractory anemia(RA) are bone marrow failure syndrome, disease-overlapping between these disease has been discussed. Aim of this study is clarified that etiology and clinical characteristics of MDS-developed AA patient and residual hemopoiesis in these bone marrow failure syndrome.
According to database that has been established by Japanese Society of Pediatric Hematology, a prognosis of MDS developed AA patient depends on chromosome abnormalities. Trisomy 8 is good, however monosomy 7 is poor prognostic marker. Incidence of MDS development in RA patients was low. Clinical and hematological response for immunosuppressive therapy (IST) was suspected as high as 50-60% in both AA and MDS-RA. MCV was also high in both type of bone marrow failure because MCV reflects ineffective erythropoiesis.
For the purpose of evaluation for residual hemopoiesis, multidimensional flow cytometry analysis (MDF) was introduced in a small-scale study. As a tentative result, MDF technique has a possibility to detect exhaustion of immature myeloid cells at an AA diagnosis and was able to follow hemopoiesis recovery after IST, and also detect aberrant Fells on abnormal maturation pathway.
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[Journal Article] Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia2008
Author(s)
Kosaka Y, Yagasaki H, Sano K, Kobayashi R, Ayukawa H, Kaneko T, Yabe H, Tsuchida M, Mugishima H, Ohara A, Morimoto A, Otsuka Y, Ohga S, Bessho F, Nakahata T, Tsukimoto I, Kojima S
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Journal Title
Blood 111(3)
Pages: 1054-1059
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia2008
Author(s)
IKosaka, Y., Yagasaki, H., Sano, K., Kobayashi, R., Ayukawa, H., Kaneko, T., Yabe, H., Tsuchida, M., Mugishima, H., Ohara, A., Morimoto, A., Otsuka, Y., Ohga, S., Bessho, F., Nakahata, T., Tsukimoto, I., Kojima, S
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Journal Title
Blood 111(3)
Pages: 1054-1059
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] ALL after one year remission by immunosuppressive therapy for aplastic anemia2007
Author(s)
Suzuki, T., Mamada, Y., Koda, K., Murata, T., Ohara, A., Kojima, S., Ishiguro, S
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Journal Title
Jpn J Pediatr Hematol 21(516)
Pages: 247-251
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings2006
Author(s)
Kobayashi R, Yabe H, Hara J, Morimoto A, Tsuchida M, Mugishima H, Ohara A, Tsukimoto I, Kato K, Kigasawa H, Tabuchi K, Nakahata T, Ohga S, Kojima S
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Journal Title
Br J Haematol 135(5)
Pages: 693-696
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings2006
Author(s)
Kobayashi, R., Yabe, H., Hara, J., Morimoto, A., Tsuchida, M., Mugishima, H., Ohara, A., Tsukimoto, I., Kato, K., Kigasawa, H., Tabuchi, K., Nakahata, T., Ohga, S., Kojima, S
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Journal Title
Br J Haematol 135(5)
Pages: 693-696
Description
「研究成果報告書概要(欧文)」より
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