2005 Fiscal Year Final Research Report Summary
Oxidative stress as a factor of the metabolic syndrome in Children's lifestyle-related Disease
| Project/Area Number |
16591067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Occupational and Environmental Health |
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Principal Investigator |
DOBASHI Kazushige University of Occupational and Environmental Health, School of Medicine, Instructor, 医学部, 助手 (60260569)
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| Co-Investigator(Kenkyū-buntansha) |
ASAYAMA Kohtaro University of Occupational and Environmental Health, School of Medicine, Part-time doctor, 医学部, 非常勤医師 (70129310)
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| Project Period (FY) |
2004 – 2005
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| Keywords | oxidative stress / free radicals / obesity / antioxidant enzymes / metabolic syndrome / transcription factor / cytokines / adipocytokines |
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| Research Abstract |
1.Plasma adiponectin levels in children with type 1 diabetes (T1DM) and in streptozotocin (STZ)-induced diabetic rats
Plasma adiponectin level was similar in both those with untreated T1DM and control children. The adiponectin levels were significantly increased in T1DM during insulin therapy. The plasma adiponectin and its expression in STZ group was low compared with the untreated control group. These results suggest that adiponectin secretion is stimulated by insulin therapy in children with T1DM, but not by T1DM itself.
2.N-acetylcysteine (NAC) attenuates TNF-α induced changes in secretion of adipocytokines from 3T3-L1 adipocytes
The treatment with TNF-α decreased antioxidant enzyme levels and activated NF-κB in 3T3-L1 adipocytes, leading to increase of IL-6 and plasminogen activator inhibitor-1 secretion, and decrease of adiponectin secretion. NAC, an antioxidant, attenuated the activation of NF-κB and the TNF-α-induced changes in these adipocytokine secretions. NAC may have the pote
… More
ntial to improve the obesity-related abnormal adipocytokine metabolism by attenuating the TNF-α-induced oxidant-antioxidant imbalance in adipocytes.
3.Postnatal development of galanin-like peptide (GALP) in rat hypothalamus
We examined the developmental change of the GALP, neuropeptide Y (NPY) and proopiomelanocortin (POMC) gene expression in the rat hypothalamus during postnatal day 1 to day 60. The development of GALP, which increased dramatically during the weaning and pubertal period. The regulatory mechanism of the expression of the GALP gene is different from that of the NPY and POMC genes during postnatal development.
4.The daily activity and metabolic derangement due to obesity in children
The daily activity measured by pedometer is related to the insulin-resistance and the changes in serum atherogenic lipoprotein level in obese children.
5.Oxidative stress in obese children
We measured serum 8-epi PGF2α and protein carbonyl group in obese children. These oxidative stress markers were elevated in obese children compared with non-obese children. Less
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[Journal Article] Comparison of two assays for fibroblast growth factor (FGF)-23.2005
Author(s)
Ito N, Fukumoto S, Takeuchi Y, Yasuda T, Hasegawa Y, Takemoto F, Tajima T, Dobashi K, Yamazaki Y, Yamashita T, Fujita T
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Journal Title
J Bone Miner Metab 23(6)
Pages: 435-440
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS) : immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models.2005
Author(s)
Kato S, Kato M, Abe Y, Matsumura T, Nishino T, Aoki M, Itoyama Y, Asayama K, Awaya A, Hirano A, Ohama E.
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Journal Title
Acta Neuropathol 110
Pages: 101-112
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Histological evidence of redox system breakdown caused by superoxide dismutase 1 (SOD1) aggregation is common to SOD1-mutated motor neurons in humans and animal models.2004
Author(s)
Kato S, Saeki Y, Aoki M, Nagai M, Ishigaki A, Itoyama Y, Kato M, Asayama K, Awaya A, Hirano A, Ohama E.
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Journal Title
Acta Neuropathol. 107
Pages: 149-158
Description
「研究成果報告書概要(欧文)」より
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