2005 Fiscal Year Final Research Report Summary
Study in genetic factors in retinopathy of prematurity
| Project/Area Number |
16591077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
HIKINO Shunji Kyushu University, Hospital, Research Associate, 大学病院, 助手 (50346780)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Kazuaki Kyushu University, Faculty of Medicine, Lecturer, 医学研究院, 講師 (50217668)
HATA Yasuaki Kyushu University, Faculty of Medicine, Research Associate, 医学研究院, 助手 (90346776)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Retinopathy of prematurity / genomic polymorphism / low-birth-weight infant / neoyascularization |
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| Research Abstract |
We investigated the polymorphisms of the genes associated with vascular endothelial growth factor (VEGF) in 145 preterm infants. These infants were divided into two groups according to gestational age at birth; group 1 included 66 infants who were born between 25 and 27 weeks, group 2 included 79 babies who were born between 29 and 32 weeks of gestational age. Ophthalmologists evaluated ROP stage with international classification of retinopathy of prematurity. We examined whether the frequencies of these polymorphisms were correlated with severe ROP (stage 3 and 4) or not in group 1, and whether those were correlated with the existence of ROP (stage 1, 2, 3, and 4) or not.
VEGF G^<+405>C polymorphism : Infants with severe ROP had significantly higher frequency of C^<+405>C genotype than infants without severe ROP in group 1 (21.7% vs 2.3%, p=0.0090). But we did not find any correlations between this polymorphism and existence of ROP in group 2.
VEGF C^<+936>T polymorphism : In group 1, the frequency of C^<+936>C genotype was significantly lower in the infants with severe ROP than in the infants without severe ROP (0% vs 16.28%, p=0.041). But there was no relationship between this polymorphism and existence of ROP in group 2.
KDR (kinase insert domain receptor) gene microsatellite polymorphism : This polymorphism composed of 4 discrete alleles. There were no associations between this polymorphism and severe ROP in group 1 or existence of ROP in group 2.
FLT-1(fms-related tyrosine kinase-1) gene microsatellite polymorphism : This polymorphism composed of 13 discrete alleles. No significant differences were observed in the allele and genotype frequencies of this polymorphism in the subject groups.
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